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Population-based case-control study of cigarette smoking and essential tremor.
Mov Disord. 2008 Jan 30; 23(2):246-52.MD

Abstract

Parkinson's disease (PD) is inversely associated with smoking cigarettes. Despite long-standing clinical links between PD and essential tremor (ET), there are surprisingly few data on smoking in ET. We studied whether smoking cigarettes is inversely associated with ET. Using a population-based, case-control design, cigarette smoking habits were assessed in 221 prevalent ET cases (75.5 +/- 7.1 years old) and 663 matched controls (74.6 +/- 7.0 years old). In logistical regression analyses, diagnosis (ET vs. control) was the dependent variable, and cigarette smoking status, the independent variable. Ever smokers were marginally less likely to have ET than were never smokers (22.0% vs. 27.0%, odds ratio [OR] 0.76, 95% confidence interval [CI] 0.55-1.04, P = 0.09). In an analysis that adjusted for confounding factors (drink-years and depressive symptoms), ever smokers were nearly half less likely to have ET than the never smokers (OR 0.58, 95% CI 0.40-0.84, P = 0.004). There was a strong inverse association between pack-years and odds of ET (adjusted OR 0.991, 95% CI 0.984-0.997, P = 0.005, i.e., with every 10 pack-year increase, odds of ET were lowered 10%). Ever smokers in the highest pack-year tertile were one-third as likely to have ET than the never smokers (adjusted OR 0.39, 95% CI 0.22-0.69, P = 0.001). We demonstrated an inverse association between ever smoking and ET. Additional studies are needed to reproduce these findings and assess whether this association is due to a biologically protective effect.

Authors+Show Affiliations

Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain. jbenitol@meditex.esNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17999431

Citation

Benito-León, Julián, et al. "Population-based Case-control Study of Cigarette Smoking and Essential Tremor." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 23, no. 2, 2008, pp. 246-52.
Benito-León J, Louis ED, Bermejo-Pareja F, et al. Population-based case-control study of cigarette smoking and essential tremor. Mov Disord. 2008;23(2):246-52.
Benito-León, J., Louis, E. D., & Bermejo-Pareja, F. (2008). Population-based case-control study of cigarette smoking and essential tremor. Movement Disorders : Official Journal of the Movement Disorder Society, 23(2), 246-52.
Benito-León J, et al. Population-based Case-control Study of Cigarette Smoking and Essential Tremor. Mov Disord. 2008 Jan 30;23(2):246-52. PubMed PMID: 17999431.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Population-based case-control study of cigarette smoking and essential tremor. AU - Benito-León,Julián, AU - Louis,Elan D, AU - Bermejo-Pareja,Félix, AU - ,, PY - 2007/11/14/pubmed PY - 2008/5/9/medline PY - 2007/11/14/entrez SP - 246 EP - 52 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 23 IS - 2 N2 - Parkinson's disease (PD) is inversely associated with smoking cigarettes. Despite long-standing clinical links between PD and essential tremor (ET), there are surprisingly few data on smoking in ET. We studied whether smoking cigarettes is inversely associated with ET. Using a population-based, case-control design, cigarette smoking habits were assessed in 221 prevalent ET cases (75.5 +/- 7.1 years old) and 663 matched controls (74.6 +/- 7.0 years old). In logistical regression analyses, diagnosis (ET vs. control) was the dependent variable, and cigarette smoking status, the independent variable. Ever smokers were marginally less likely to have ET than were never smokers (22.0% vs. 27.0%, odds ratio [OR] 0.76, 95% confidence interval [CI] 0.55-1.04, P = 0.09). In an analysis that adjusted for confounding factors (drink-years and depressive symptoms), ever smokers were nearly half less likely to have ET than the never smokers (OR 0.58, 95% CI 0.40-0.84, P = 0.004). There was a strong inverse association between pack-years and odds of ET (adjusted OR 0.991, 95% CI 0.984-0.997, P = 0.005, i.e., with every 10 pack-year increase, odds of ET were lowered 10%). Ever smokers in the highest pack-year tertile were one-third as likely to have ET than the never smokers (adjusted OR 0.39, 95% CI 0.22-0.69, P = 0.001). We demonstrated an inverse association between ever smoking and ET. Additional studies are needed to reproduce these findings and assess whether this association is due to a biologically protective effect. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/17999431/Population_based_case_control_study_of_cigarette_smoking_and_essential_tremor_ L2 - https://doi.org/10.1002/mds.21810 DB - PRIME DP - Unbound Medicine ER -