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Decrease in oxidative stress through supplementation of vitamins C and E is associated with a reduction in blood pressure in patients with essential hypertension.
Clin Sci (Lond). 2008 May; 114(10):625-34.CS

Abstract

Oxidative stress has been associated with mechanisms of EH (essential hypertension). The aim of the present study was to test the hypothesis that the antioxidant properties of vitamins C and E are associated with a decrease in BP (blood pressure) in patients with EH. A randomized double-blind placebo-controlled clinical trial was conducted in 110 men with grade 1 EH (35-60 years of age without obesity, dyslipidaemia and diabetes mellitus, non-smokers, not undergoing vigorous physical exercise, without the use of any medication and/or high consumption of fruit and vegetables). Participants were randomly assigned to receive either vitamins C+E [vitamin C (1 g/day) plus vitamin E (400 international units/day)] or placebo for 8 weeks. Measurements included 24 h ambulatory BP and blood analysis of oxidative-stress-related parameters in erythrocytes (GSH/GSSH ratio, antioxidant enzymes and malondialdehyde) and plasma [FRAP (ferric reducing ability of plasma)], and levels of 8-isoprostane, vitamins C and E were measured at baseline and after treatment. Following administration of vitamins C+E, patients with EH had significantly lower systolic BP, diastolic BP and mean arterial BP and higher erythrocyte and serum antioxidant capacity compared with either placebo-treated patients with EH or the patients with EH at baseline prior to treatment. BP correlated positively with plasma 8-isoprostane levels and negatively with plasma FRAP levels in the vitamins C+E- and placebo-treated groups. In conclusion, the present study supports the view that oxidative stress is involved in the pathogenesis of EH, and that enhancement of antioxidant status by supplementation with vitamins C and E in patients with EH is associated with lower BP. This suggests intervention with antioxidants as an adjunct therapy for hypertension.

Authors+Show Affiliations

Laboratory of Renal Pathophysiology, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile. rrodrigo@med.uchile.clNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17999638

Citation

Rodrigo, Ramón, et al. "Decrease in Oxidative Stress Through Supplementation of Vitamins C and E Is Associated With a Reduction in Blood Pressure in Patients With Essential Hypertension." Clinical Science (London, England : 1979), vol. 114, no. 10, 2008, pp. 625-34.
Rodrigo R, Prat H, Passalacqua W, et al. Decrease in oxidative stress through supplementation of vitamins C and E is associated with a reduction in blood pressure in patients with essential hypertension. Clin Sci (Lond). 2008;114(10):625-34.
Rodrigo, R., Prat, H., Passalacqua, W., Araya, J., & Bächler, J. P. (2008). Decrease in oxidative stress through supplementation of vitamins C and E is associated with a reduction in blood pressure in patients with essential hypertension. Clinical Science (London, England : 1979), 114(10), 625-34.
Rodrigo R, et al. Decrease in Oxidative Stress Through Supplementation of Vitamins C and E Is Associated With a Reduction in Blood Pressure in Patients With Essential Hypertension. Clin Sci (Lond). 2008;114(10):625-34. PubMed PMID: 17999638.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decrease in oxidative stress through supplementation of vitamins C and E is associated with a reduction in blood pressure in patients with essential hypertension. AU - Rodrigo,Ramón, AU - Prat,Hernán, AU - Passalacqua,Walter, AU - Araya,Julia, AU - Bächler,Jean P, PY - 2007/11/15/pubmed PY - 2008/5/9/medline PY - 2007/11/15/entrez SP - 625 EP - 34 JF - Clinical science (London, England : 1979) JO - Clin Sci (Lond) VL - 114 IS - 10 N2 - Oxidative stress has been associated with mechanisms of EH (essential hypertension). The aim of the present study was to test the hypothesis that the antioxidant properties of vitamins C and E are associated with a decrease in BP (blood pressure) in patients with EH. A randomized double-blind placebo-controlled clinical trial was conducted in 110 men with grade 1 EH (35-60 years of age without obesity, dyslipidaemia and diabetes mellitus, non-smokers, not undergoing vigorous physical exercise, without the use of any medication and/or high consumption of fruit and vegetables). Participants were randomly assigned to receive either vitamins C+E [vitamin C (1 g/day) plus vitamin E (400 international units/day)] or placebo for 8 weeks. Measurements included 24 h ambulatory BP and blood analysis of oxidative-stress-related parameters in erythrocytes (GSH/GSSH ratio, antioxidant enzymes and malondialdehyde) and plasma [FRAP (ferric reducing ability of plasma)], and levels of 8-isoprostane, vitamins C and E were measured at baseline and after treatment. Following administration of vitamins C+E, patients with EH had significantly lower systolic BP, diastolic BP and mean arterial BP and higher erythrocyte and serum antioxidant capacity compared with either placebo-treated patients with EH or the patients with EH at baseline prior to treatment. BP correlated positively with plasma 8-isoprostane levels and negatively with plasma FRAP levels in the vitamins C+E- and placebo-treated groups. In conclusion, the present study supports the view that oxidative stress is involved in the pathogenesis of EH, and that enhancement of antioxidant status by supplementation with vitamins C and E in patients with EH is associated with lower BP. This suggests intervention with antioxidants as an adjunct therapy for hypertension. SN - 1470-8736 UR - https://www.unboundmedicine.com/medline/citation/17999638/Decrease_in_oxidative_stress_through_supplementation_of_vitamins_C_and_E_is_associated_with_a_reduction_in_blood_pressure_in_patients_with_essential_hypertension_ L2 - https://portlandpress.com/clinsci/article-lookup/doi/10.1042/CS20070343 DB - PRIME DP - Unbound Medicine ER -