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Calcium, dairy foods, and risk of incident and fatal prostate cancer: the NIH-AARP Diet and Health Study.

Abstract

Calcium and dairy foods in relation to prostate cancer were examined in the National Institutes of Health (NIH)-AARP (formerly known as the American Association of Retired Persons) Diet and Health Study (1995/1996-2001). Diet was assessed with a food frequency questionnaire at baseline. Multivariate relative risks and 95% confidence intervals were estimated by Cox regression. During up to 6 years of follow-up (n = 293,888), the authors identified 10,180 total prostate cancer cases (8,754 nonadvanced, 1,426 advanced, and 178 fatal cases). Total and supplemental calcium were unrelated to total and nonadvanced prostate cancer. However, a statistically nonsignificant positive association with total calcium was observed for advanced (> or = 2,000 vs. 500-<750 mg/day: relative risk (RR) = 1.25, 95% confidence interval (CI): 0.91, 1.71; p(trend) = 0.06) and fatal (> or = 1,000 vs. 500-<750 mg/day: RR = 1.39, 95% CI: 0.92, 2.09; p(trend) = 0.10) prostate cancer. Skim milk, but not other dairy foods, was associated with increased risk of advanced prostate cancer (> or = 2 vs. zero servings/day: RR = 1.23, 95% CI: 0.99, 1.54; p(trend) = 0.01). In contrast, calcium from nondairy foods was associated with lower risk of nonadvanced prostate cancer (> or = 600 vs. < 250 mg/day: RR = 0.82, 95% CI: 0.68, 0.99; p(trend) = 0.04). Although the authors cannot definitively rule out a weak association for aggressive prostate cancer, their findings do not provide strong support for the hypothesis that calcium and dairy foods increase prostate cancer risk.

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  • Authors+Show Affiliations

    ,

    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA. parkyik@mail.nih.gov

    , , , ,

    Source

    American journal of epidemiology 166:11 2007 Dec 01 pg 1270-9

    MeSH

    Adult
    Aged
    Calcium, Dietary
    Dairy Products
    Humans
    Incidence
    Male
    Middle Aged
    Multivariate Analysis
    Neoplasm Staging
    Proportional Hazards Models
    Prostatic Neoplasms
    Registries
    Risk Assessment
    SEER Program
    Surveys and Questionnaires
    United States
    Vitamin D

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Intramural

    Language

    eng

    PubMed ID

    18000020

    Citation

    Park, Yikyung, et al. "Calcium, Dairy Foods, and Risk of Incident and Fatal Prostate Cancer: the NIH-AARP Diet and Health Study." American Journal of Epidemiology, vol. 166, no. 11, 2007, pp. 1270-9.
    Park Y, Mitrou PN, Kipnis V, et al. Calcium, dairy foods, and risk of incident and fatal prostate cancer: the NIH-AARP Diet and Health Study. Am J Epidemiol. 2007;166(11):1270-9.
    Park, Y., Mitrou, P. N., Kipnis, V., Hollenbeck, A., Schatzkin, A., & Leitzmann, M. F. (2007). Calcium, dairy foods, and risk of incident and fatal prostate cancer: the NIH-AARP Diet and Health Study. American Journal of Epidemiology, 166(11), pp. 1270-9.
    Park Y, et al. Calcium, Dairy Foods, and Risk of Incident and Fatal Prostate Cancer: the NIH-AARP Diet and Health Study. Am J Epidemiol. 2007 Dec 1;166(11):1270-9. PubMed PMID: 18000020.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Calcium, dairy foods, and risk of incident and fatal prostate cancer: the NIH-AARP Diet and Health Study. AU - Park,Yikyung, AU - Mitrou,Panagiota N, AU - Kipnis,Victor, AU - Hollenbeck,Albert, AU - Schatzkin,Arthur, AU - Leitzmann,Michael F, Y1 - 2007/10/12/ PY - 2007/11/15/pubmed PY - 2007/12/14/medline PY - 2007/11/15/entrez SP - 1270 EP - 9 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 166 IS - 11 N2 - Calcium and dairy foods in relation to prostate cancer were examined in the National Institutes of Health (NIH)-AARP (formerly known as the American Association of Retired Persons) Diet and Health Study (1995/1996-2001). Diet was assessed with a food frequency questionnaire at baseline. Multivariate relative risks and 95% confidence intervals were estimated by Cox regression. During up to 6 years of follow-up (n = 293,888), the authors identified 10,180 total prostate cancer cases (8,754 nonadvanced, 1,426 advanced, and 178 fatal cases). Total and supplemental calcium were unrelated to total and nonadvanced prostate cancer. However, a statistically nonsignificant positive association with total calcium was observed for advanced (> or = 2,000 vs. 500-<750 mg/day: relative risk (RR) = 1.25, 95% confidence interval (CI): 0.91, 1.71; p(trend) = 0.06) and fatal (> or = 1,000 vs. 500-<750 mg/day: RR = 1.39, 95% CI: 0.92, 2.09; p(trend) = 0.10) prostate cancer. Skim milk, but not other dairy foods, was associated with increased risk of advanced prostate cancer (> or = 2 vs. zero servings/day: RR = 1.23, 95% CI: 0.99, 1.54; p(trend) = 0.01). In contrast, calcium from nondairy foods was associated with lower risk of nonadvanced prostate cancer (> or = 600 vs. < 250 mg/day: RR = 0.82, 95% CI: 0.68, 0.99; p(trend) = 0.04). Although the authors cannot definitively rule out a weak association for aggressive prostate cancer, their findings do not provide strong support for the hypothesis that calcium and dairy foods increase prostate cancer risk. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/18000020/Calcium_dairy_foods_and_risk_of_incident_and_fatal_prostate_cancer:_the_NIH_AARP_Diet_and_Health_Study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwm268 DB - PRIME DP - Unbound Medicine ER -