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Genetic diversity of Burkholderia pseudomallei isolates in Australia.
J Clin Microbiol. 2008 Jan; 46(1):249-54.JC

Abstract

Melioidosis is caused by the gram-negative saprophytic bacterium Burkholderia pseudomallei, which is endemic to southeast Asia and northern Australia. We have previously found evidence of geographic localization of strains based on multilocus sequence typing (MLST). In this study, we examined the diversity of 277 isolates from northern Australia, which were resolved into 159 different sequence types. No sequence types were common to both Queensland and the Northern Territory, and there was significant differentiation between the alleles present in the two regions. The considerable diversity in sequence types contrasts with the limited diversity of alleles at MLST loci, supporting previous work suggesting a high rate of recombination relative to mutation in B. pseudomallei, where new sequence types are primarily generated by reassortment of existing alleles.

Authors+Show Affiliations

Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18003806

Citation

Cheng, Allen C., et al. "Genetic Diversity of Burkholderia Pseudomallei Isolates in Australia." Journal of Clinical Microbiology, vol. 46, no. 1, 2008, pp. 249-54.
Cheng AC, Ward L, Godoy D, et al. Genetic diversity of Burkholderia pseudomallei isolates in Australia. J Clin Microbiol. 2008;46(1):249-54.
Cheng, A. C., Ward, L., Godoy, D., Norton, R., Mayo, M., Gal, D., Spratt, B. G., & Currie, B. J. (2008). Genetic diversity of Burkholderia pseudomallei isolates in Australia. Journal of Clinical Microbiology, 46(1), 249-54.
Cheng AC, et al. Genetic Diversity of Burkholderia Pseudomallei Isolates in Australia. J Clin Microbiol. 2008;46(1):249-54. PubMed PMID: 18003806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic diversity of Burkholderia pseudomallei isolates in Australia. AU - Cheng,Allen C, AU - Ward,Linda, AU - Godoy,Daniel, AU - Norton,Robert, AU - Mayo,Mark, AU - Gal,Daniel, AU - Spratt,Brian G, AU - Currie,Bart J, Y1 - 2007/11/14/ PY - 2007/11/16/pubmed PY - 2008/4/9/medline PY - 2007/11/16/entrez SP - 249 EP - 54 JF - Journal of clinical microbiology JO - J Clin Microbiol VL - 46 IS - 1 N2 - Melioidosis is caused by the gram-negative saprophytic bacterium Burkholderia pseudomallei, which is endemic to southeast Asia and northern Australia. We have previously found evidence of geographic localization of strains based on multilocus sequence typing (MLST). In this study, we examined the diversity of 277 isolates from northern Australia, which were resolved into 159 different sequence types. No sequence types were common to both Queensland and the Northern Territory, and there was significant differentiation between the alleles present in the two regions. The considerable diversity in sequence types contrasts with the limited diversity of alleles at MLST loci, supporting previous work suggesting a high rate of recombination relative to mutation in B. pseudomallei, where new sequence types are primarily generated by reassortment of existing alleles. SN - 1098-660X UR - https://www.unboundmedicine.com/medline/citation/18003806/Genetic_diversity_of_Burkholderia_pseudomallei_isolates_in_Australia_ L2 - http://jcm.asm.org/cgi/pmidlookup?view=long&pmid=18003806 DB - PRIME DP - Unbound Medicine ER -