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Predicted risk of coronary heart disease among persons with type 2 diabetes.
Coron Artery Dis. 2007 Dec; 18(8):595-600.CA

Abstract

BACKGROUND

Diabetes is an independent risk factor for the development of coronary heart disease (CHD). We evaluated whether there are racial/ethnic differences in predicted probability of CHD among persons with type 2 diabetes from the 1999-2002 National Health and Nutrition Examination Survey.

METHODS

Adults with type 2 diabetes without cardiovascular disease (n=585) were evaluated; the United Kingdom Prospective Diabetes Study (UKPDS) Risk Engine was used to develop estimates of CHD and Framingham Risk Score (FRS) was used to assess the 10-year CHD risk. Chi-square tests and analysis of variance were used to assess differences between racial/ethnic groups in risk factors and predicted probability for CHD.

RESULTS

Risk factors for CHD differed significantly amongst the three racial/ethnic groups. Whites had lower mean A1C concentrations (7.3%+/-0.2) than blacks (8.1%+/-0.2, P<0.05) or Mexican Americans (8.1%+/-0.2, P<0.05). Systolic blood pressure was higher in blacks compared with whites (P<0.05) and in Mexican American men compared with white men (P<0.05). Total cholesterol differed insignificantly by race/ethnicity whereas high-density lipoprotein cholesterol was higher in blacks compared with whites and Mexican Americans. Blacks had the greatest 5, 10, 15, and 20-year predicted risks of CHD among men, whereas whites had the greatest predicted risks among women. When evaluated by the FRS, the 10-year predicted risk of CHD was estimated to be 22.5% by UKPDS and 17% using FRS.

CONCLUSIONS

UKPDS estimates of probability of CHD were similar across race/ethnicities, indicating that the risk factors tended to balance out. Despite differences in individual risk factors, the estimated risk for CHD was similar for all persons with diabetes.

Authors+Show Affiliations

Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA. jkirk@wfubmc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18004108

Citation

Kirk, Julienne K., et al. "Predicted Risk of Coronary Heart Disease Among Persons With Type 2 Diabetes." Coronary Artery Disease, vol. 18, no. 8, 2007, pp. 595-600.
Kirk JK, Bertoni AG, Case D, et al. Predicted risk of coronary heart disease among persons with type 2 diabetes. Coron Artery Dis. 2007;18(8):595-600.
Kirk, J. K., Bertoni, A. G., Case, D., Bell, R. A., Goff, D. C., & Narayan, K. M. (2007). Predicted risk of coronary heart disease among persons with type 2 diabetes. Coronary Artery Disease, 18(8), 595-600.
Kirk JK, et al. Predicted Risk of Coronary Heart Disease Among Persons With Type 2 Diabetes. Coron Artery Dis. 2007;18(8):595-600. PubMed PMID: 18004108.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predicted risk of coronary heart disease among persons with type 2 diabetes. AU - Kirk,Julienne K, AU - Bertoni,Alain G, AU - Case,Doug, AU - Bell,Ronny A, AU - Goff,David C,Jr AU - Narayan,K M Venkat, PY - 2007/11/16/pubmed PY - 2008/4/30/medline PY - 2007/11/16/entrez SP - 595 EP - 600 JF - Coronary artery disease JO - Coron Artery Dis VL - 18 IS - 8 N2 - BACKGROUND: Diabetes is an independent risk factor for the development of coronary heart disease (CHD). We evaluated whether there are racial/ethnic differences in predicted probability of CHD among persons with type 2 diabetes from the 1999-2002 National Health and Nutrition Examination Survey. METHODS: Adults with type 2 diabetes without cardiovascular disease (n=585) were evaluated; the United Kingdom Prospective Diabetes Study (UKPDS) Risk Engine was used to develop estimates of CHD and Framingham Risk Score (FRS) was used to assess the 10-year CHD risk. Chi-square tests and analysis of variance were used to assess differences between racial/ethnic groups in risk factors and predicted probability for CHD. RESULTS: Risk factors for CHD differed significantly amongst the three racial/ethnic groups. Whites had lower mean A1C concentrations (7.3%+/-0.2) than blacks (8.1%+/-0.2, P<0.05) or Mexican Americans (8.1%+/-0.2, P<0.05). Systolic blood pressure was higher in blacks compared with whites (P<0.05) and in Mexican American men compared with white men (P<0.05). Total cholesterol differed insignificantly by race/ethnicity whereas high-density lipoprotein cholesterol was higher in blacks compared with whites and Mexican Americans. Blacks had the greatest 5, 10, 15, and 20-year predicted risks of CHD among men, whereas whites had the greatest predicted risks among women. When evaluated by the FRS, the 10-year predicted risk of CHD was estimated to be 22.5% by UKPDS and 17% using FRS. CONCLUSIONS: UKPDS estimates of probability of CHD were similar across race/ethnicities, indicating that the risk factors tended to balance out. Despite differences in individual risk factors, the estimated risk for CHD was similar for all persons with diabetes. SN - 0954-6928 UR - https://www.unboundmedicine.com/medline/citation/18004108/Predicted_risk_of_coronary_heart_disease_among_persons_with_type_2_diabetes_ L2 - https://doi.org/10.1097/MCA.0b013e3282f0902b DB - PRIME DP - Unbound Medicine ER -