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Risk factors for epithelial ovarian tumours of borderline malignancy.
Int J Epidemiol 1991; 20(4):871-7IJ

Abstract

A case-control study was conducted on 91 cases with histologically-confirmed borderline ovarian tumours and 237 control subjects in hospital for acute non-gynaecological, hormonal or neoplastic disease. Women reporting three or more births, compared to nulliparae, had a relative risk (RR) estimate of 0.6, but this finding was not statistically significant (95% confidence interval (CI): 0.2-1.4). The risk of borderline tumours increased, although not significantly, with later age at first birth: compared to women reporting first birth at age 24 or before, the RRs were 1.3 and 1.7 in those reporting respectively their first birth at age 25-29 and 30 years or more. No significant relationship emerged between borderline ovarian cancer and age at menarche, menopausal status and lifelong menstrual pattern. Cases tended to report a later age at menopause than controls, but the trend in risk was not statistically significant. Nine cases (9.9%) and 68 controls (24.9%) reported oral contraceptive use: compared with never users the multivariate RR for ever users was 0.3, and the risk dropped with duration of use to 0.2 in users for two years or more (chi 2 (1) trend = 12.70, p less than 0.001). This study provides epidemiological evidence of a pathogenetic continuum between borderline and invasive ovarian tumours.

Authors+Show Affiliations

Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1800425

Citation

Parazzini, F, et al. "Risk Factors for Epithelial Ovarian Tumours of Borderline Malignancy." International Journal of Epidemiology, vol. 20, no. 4, 1991, pp. 871-7.
Parazzini F, Restelli C, La Vecchia C, et al. Risk factors for epithelial ovarian tumours of borderline malignancy. Int J Epidemiol. 1991;20(4):871-7.
Parazzini, F., Restelli, C., La Vecchia, C., Negri, E., Chiari, S., Maggi, R., & Mangioni, C. (1991). Risk factors for epithelial ovarian tumours of borderline malignancy. International Journal of Epidemiology, 20(4), pp. 871-7.
Parazzini F, et al. Risk Factors for Epithelial Ovarian Tumours of Borderline Malignancy. Int J Epidemiol. 1991;20(4):871-7. PubMed PMID: 1800425.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for epithelial ovarian tumours of borderline malignancy. AU - Parazzini,F, AU - Restelli,C, AU - La Vecchia,C, AU - Negri,E, AU - Chiari,S, AU - Maggi,R, AU - Mangioni,C, PY - 1991/12/1/pubmed PY - 1991/12/1/medline PY - 1991/12/1/entrez KW - Abortion, Induced KW - Age Factors KW - Biology KW - Cancer KW - Case Control Studies KW - Contraception KW - Contraceptive Methods--beneficial effects KW - Demographic Factors KW - Developed Countries KW - Diseases KW - Europe KW - Family Planning KW - Fertility KW - Fertility Control, Postconception KW - Fertility Measurements KW - Genitalia KW - Genitalia, Female KW - Histology KW - Italy KW - Maternal Age KW - Mediterranean Countries KW - Methodological Studies KW - Neoplasms KW - Nulliparity KW - Oral Contraceptives--beneficial effects KW - Ovarian Cancer KW - Ovary KW - Parental Age KW - Parity KW - Physiology KW - Population KW - Population Characteristics KW - Population Dynamics KW - Research Methodology KW - Risk Factors KW - Southern Europe KW - Studies KW - Urogenital System SP - 871 EP - 7 JF - International journal of epidemiology JO - Int J Epidemiol VL - 20 IS - 4 N2 - A case-control study was conducted on 91 cases with histologically-confirmed borderline ovarian tumours and 237 control subjects in hospital for acute non-gynaecological, hormonal or neoplastic disease. Women reporting three or more births, compared to nulliparae, had a relative risk (RR) estimate of 0.6, but this finding was not statistically significant (95% confidence interval (CI): 0.2-1.4). The risk of borderline tumours increased, although not significantly, with later age at first birth: compared to women reporting first birth at age 24 or before, the RRs were 1.3 and 1.7 in those reporting respectively their first birth at age 25-29 and 30 years or more. No significant relationship emerged between borderline ovarian cancer and age at menarche, menopausal status and lifelong menstrual pattern. Cases tended to report a later age at menopause than controls, but the trend in risk was not statistically significant. Nine cases (9.9%) and 68 controls (24.9%) reported oral contraceptive use: compared with never users the multivariate RR for ever users was 0.3, and the risk dropped with duration of use to 0.2 in users for two years or more (chi 2 (1) trend = 12.70, p less than 0.001). This study provides epidemiological evidence of a pathogenetic continuum between borderline and invasive ovarian tumours. SN - 0300-5771 UR - https://www.unboundmedicine.com/medline/citation/1800425/Risk_factors_for_epithelial_ovarian_tumours_of_borderline_malignancy_ L2 - https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/20.4.871 DB - PRIME DP - Unbound Medicine ER -