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Surgical correction of varicose vein disease under micronized diosmin protection (results of the Russian multicenter controlled trial DEFANS).
Angiol Sosud Khir. 2007; 13(2):47-55.AS

Abstract

The paper presents the results of DEFANS trial (Detralex - assessment of efficacy and safety for combined phlebectomy). The study enrolled 245 patients with varicose vein disease, who underwent unilateral combined phlebectomy. The main group (n=200) received micronized diosmin (Detralex, 1000 mg/day) for 2 weeks before and 30 days after the procedure; control group (n=45) did not receive Detralex in pre- and postoperative period. Pain severity by 10-point visual analog scale (VAS), an area of subcutaneous hemorrhage in the zone of femoral great saphenous vein resection (by original 12-point scale) and subjective feelings of limb heaviness and fatigability were evaluated 7, 14 and 30 days after the procedure. Subjective symptoms and the area of subcutaneous hemorrhage were significantly lower in the main group, then in control: 7 days after the procedure VAS score was 2.9 and 3.5, respectively; hemorrhage area - 3.4 and 4.6 points, respectively. The same trend was observed for limb heaviness and fatigability, evidencing the better exercise and orthostatic tolerance among patients of the main group in early postoperative period. Quality of life assessment by CIVIQ failed to reveal statistically significant difference between main and control groups in 4-weeks postoperative follow-up. Micronized diosmin in pre- and postoperative period after plebectomy helps to attenuate pain syndrome, to decrease postoperative haematomas and accelerate their resorption, to increase exercise tolerance in early postoperative period.

Authors+Show Affiliations

Department of Faculty Surgery, Faculty for Postgraduate Training of Physicians, Russian State Medical University, Moscow.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study

Language

eng rus

PubMed ID

18004259

Citation

Pokrovsky, A V., et al. "Surgical Correction of Varicose Vein Disease Under Micronized Diosmin Protection (results of the Russian Multicenter Controlled Trial DEFANS)." Angiologiia I Sosudistaia Khirurgiia = Angiology and Vascular Surgery, vol. 13, no. 2, 2007, pp. 47-55.
Pokrovsky AV, Saveljev VS, Kirienko AI, et al. Surgical correction of varicose vein disease under micronized diosmin protection (results of the Russian multicenter controlled trial DEFANS). Angiol Sosud Khir. 2007;13(2):47-55.
Pokrovsky, A. V., Saveljev, V. S., Kirienko, A. I., Bogachev, V. Y., Zolotukhin, I. A., Sapelkin, S. V., Shvalb, P. G., Zhukov, B. N., Vozlubleny, S. I., Sabelnikov, V. V., Voskanian, Y. E., Katelnitsky, I. I., Burleva, E. P., & Tolstikhin, V. Y. (2007). Surgical correction of varicose vein disease under micronized diosmin protection (results of the Russian multicenter controlled trial DEFANS). Angiologiia I Sosudistaia Khirurgiia = Angiology and Vascular Surgery, 13(2), 47-55.
Pokrovsky AV, et al. Surgical Correction of Varicose Vein Disease Under Micronized Diosmin Protection (results of the Russian Multicenter Controlled Trial DEFANS). Angiol Sosud Khir. 2007;13(2):47-55. PubMed PMID: 18004259.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Surgical correction of varicose vein disease under micronized diosmin protection (results of the Russian multicenter controlled trial DEFANS). AU - Pokrovsky,A V, AU - Saveljev,V S, AU - Kirienko,A I, AU - Bogachev,V Yu, AU - Zolotukhin,I A, AU - Sapelkin,S V, AU - Shvalb,P G, AU - Zhukov,B N, AU - Vozlubleny,S I, AU - Sabelnikov,V V, AU - Voskanian,Yu E, AU - Katelnitsky,I I, AU - Burleva,E P, AU - Tolstikhin,V Yu, PY - 2007/11/16/pubmed PY - 2007/12/18/medline PY - 2007/11/16/entrez SP - 47 EP - 55 JF - Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery JO - Angiol Sosud Khir VL - 13 IS - 2 N2 - The paper presents the results of DEFANS trial (Detralex - assessment of efficacy and safety for combined phlebectomy). The study enrolled 245 patients with varicose vein disease, who underwent unilateral combined phlebectomy. The main group (n=200) received micronized diosmin (Detralex, 1000 mg/day) for 2 weeks before and 30 days after the procedure; control group (n=45) did not receive Detralex in pre- and postoperative period. Pain severity by 10-point visual analog scale (VAS), an area of subcutaneous hemorrhage in the zone of femoral great saphenous vein resection (by original 12-point scale) and subjective feelings of limb heaviness and fatigability were evaluated 7, 14 and 30 days after the procedure. Subjective symptoms and the area of subcutaneous hemorrhage were significantly lower in the main group, then in control: 7 days after the procedure VAS score was 2.9 and 3.5, respectively; hemorrhage area - 3.4 and 4.6 points, respectively. The same trend was observed for limb heaviness and fatigability, evidencing the better exercise and orthostatic tolerance among patients of the main group in early postoperative period. Quality of life assessment by CIVIQ failed to reveal statistically significant difference between main and control groups in 4-weeks postoperative follow-up. Micronized diosmin in pre- and postoperative period after plebectomy helps to attenuate pain syndrome, to decrease postoperative haematomas and accelerate their resorption, to increase exercise tolerance in early postoperative period. SN - 1027-6661 UR - https://www.unboundmedicine.com/medline/citation/18004259/Surgical_correction_of_varicose_vein_disease_under_micronized_diosmin_protection__results_of_the_Russian_multicenter_controlled_trial_DEFANS__ L2 - https://medlineplus.gov/varicoseveins.html DB - PRIME DP - Unbound Medicine ER -