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The diagnostic accuracy of different natriuretic peptides in the investigation of canine cardiac disease.
J Small Anim Pract. 2008 Jan; 49(1):26-32.JS

Abstract

OBJECTIVES

We aimed to validate and determine the accuracy of a new sandwich ELISA for canine N-terminal pro-B-type natriuretic peptide (NT-proBNP) in the discrimination of canine patients with cardiac disease from those with respiratory disease and to determine the effect of confounding variables on NT-proBNP concentrations.

METHODS

Validation studies for the new assay were undertaken. Concentrations of N-terminal atrial natriuretic peptide (NT-proANP) and NT-proBNP in both ethylenediaminetetraacetic acid (EDTA) plasma and serum were estimated in samples from 77 dogs at a laboratory blinded to the clinical status of the patient. The diagnostic accuracy of the each sample type and test was evaluated using receiver operating characteristic curves. The effect of age, gender and indicators of renal function was evaluated using a multivariate regression analysis.

RESULTS

Concentrations of NT-proBNP in both serum and plasma accurately discriminated dogs with respiratory disease from those with cardiac disease, with an optimum cut-off concentration of 210 pmol/l. NT-proBNP concentrations were unaffected by sample type. Increasing creatinine concentration is associated with increasing concentration of NT-proBNP. Age and gender were not found to have significant effects on natriuretic peptide concentrations in this population.

CLINICAL SIGNIFICANCE

Canine NT-proBNP appears to be a useful marker of the presence of cardiac disease, although concentrations must be interpreted in the light of the patient's renal function.

Authors+Show Affiliations

Department of Veterinary Clinical Sciences, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Validation Study

Language

eng

PubMed ID

18005104

Citation

Boswood, A, et al. "The Diagnostic Accuracy of Different Natriuretic Peptides in the Investigation of Canine Cardiac Disease." The Journal of Small Animal Practice, vol. 49, no. 1, 2008, pp. 26-32.
Boswood A, Dukes-McEwan J, Loureiro J, et al. The diagnostic accuracy of different natriuretic peptides in the investigation of canine cardiac disease. J Small Anim Pract. 2008;49(1):26-32.
Boswood, A., Dukes-McEwan, J., Loureiro, J., James, R. A., Martin, M., Stafford-Johnson, M., Smith, P., Little, C., & Attree, S. (2008). The diagnostic accuracy of different natriuretic peptides in the investigation of canine cardiac disease. The Journal of Small Animal Practice, 49(1), 26-32.
Boswood A, et al. The Diagnostic Accuracy of Different Natriuretic Peptides in the Investigation of Canine Cardiac Disease. J Small Anim Pract. 2008;49(1):26-32. PubMed PMID: 18005104.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The diagnostic accuracy of different natriuretic peptides in the investigation of canine cardiac disease. AU - Boswood,A, AU - Dukes-McEwan,J, AU - Loureiro,J, AU - James,R A, AU - Martin,M, AU - Stafford-Johnson,M, AU - Smith,P, AU - Little,C, AU - Attree,S, Y1 - 2007/11/13/ PY - 2007/11/17/pubmed PY - 2008/3/25/medline PY - 2007/11/17/entrez SP - 26 EP - 32 JF - The Journal of small animal practice JO - J Small Anim Pract VL - 49 IS - 1 N2 - OBJECTIVES: We aimed to validate and determine the accuracy of a new sandwich ELISA for canine N-terminal pro-B-type natriuretic peptide (NT-proBNP) in the discrimination of canine patients with cardiac disease from those with respiratory disease and to determine the effect of confounding variables on NT-proBNP concentrations. METHODS: Validation studies for the new assay were undertaken. Concentrations of N-terminal atrial natriuretic peptide (NT-proANP) and NT-proBNP in both ethylenediaminetetraacetic acid (EDTA) plasma and serum were estimated in samples from 77 dogs at a laboratory blinded to the clinical status of the patient. The diagnostic accuracy of the each sample type and test was evaluated using receiver operating characteristic curves. The effect of age, gender and indicators of renal function was evaluated using a multivariate regression analysis. RESULTS: Concentrations of NT-proBNP in both serum and plasma accurately discriminated dogs with respiratory disease from those with cardiac disease, with an optimum cut-off concentration of 210 pmol/l. NT-proBNP concentrations were unaffected by sample type. Increasing creatinine concentration is associated with increasing concentration of NT-proBNP. Age and gender were not found to have significant effects on natriuretic peptide concentrations in this population. CLINICAL SIGNIFICANCE: Canine NT-proBNP appears to be a useful marker of the presence of cardiac disease, although concentrations must be interpreted in the light of the patient's renal function. SN - 0022-4510 UR - https://www.unboundmedicine.com/medline/citation/18005104/The_diagnostic_accuracy_of_different_natriuretic_peptides_in_the_investigation_of_canine_cardiac_disease_ L2 - https://doi.org/10.1111/j.1748-5827.2007.00510.x DB - PRIME DP - Unbound Medicine ER -