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Effects of vagus nerve stimulation on cardiovascular regulation in patients with epilepsy.
Acta Neurol Scand. 2008 Apr; 117(4):231-6.AN

Abstract

OBJECTIVE

To evaluate the impact of vagus nerve stimulation (VNS) on heart rate and blood pressure (BP) modulation in epilepsy patients.

MATERIAL AND METHODS

Twenty-one epilepsy patients with VNS were tested during on (60 s) and off (5 min) phases. We monitored BP, RR intervals (RRI) and respiration. Spectral analysis was performed in low- (LF: 0.04-0.15 Hz) and high-frequency bands (HF: 0.15-0.5 Hz). For coherences above 0.5, we calculated the LF transfer function between systolic BP and RRI, and the HF transfer function gain and phase between RRI and respiration. Differences between the on and off phases were evaluated using Wilcoxon test.

RESULTS

VNS did not change RRI and BP values. The LF power of BP and the LF and HF power of RRI increased significantly. There was a slight change in the RRI/BP LF gain and the RRI/respiration HF gain (ns). The HF phase between RRI and respiration decreased significantly.

CONCLUSIONS

Our findings show that VNS influences both sympathetic and parasympathetic cardiovascular modulation. However, our results also show that VNS does not negatively influence autonomic cardiovascular regulation.

Authors+Show Affiliations

Stemper B
Department of Neurology, University of Erlangen-Nurnberg, Erlangen, Germany.
Devinsky O
No affiliation info available
Haendl T
No affiliation info available
Welsch G
No affiliation info available
Hilz MJ
No affiliation info available

MeSH

AdultArrhythmias, CardiacAutonomic PathwaysBaroreflexBlood PressureCardiovascular Physiological PhenomenaElectric Stimulation TherapyEpilepsyFemaleHeartHeart RateHumansMaleMiddle AgedParasympathetic Nervous SystemRespirationRisk FactorsSympathetic Nervous SystemVagus Nerve

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18005223

Citation

Stemper, B, et al. "Effects of Vagus Nerve Stimulation On Cardiovascular Regulation in Patients With Epilepsy." Acta Neurologica Scandinavica, vol. 117, no. 4, 2008, pp. 231-6.
Stemper B, Devinsky O, Haendl T, et al. Effects of vagus nerve stimulation on cardiovascular regulation in patients with epilepsy. Acta Neurol Scand. 2008;117(4):231-6.
Stemper, B., Devinsky, O., Haendl, T., Welsch, G., & Hilz, M. J. (2008). Effects of vagus nerve stimulation on cardiovascular regulation in patients with epilepsy. Acta Neurologica Scandinavica, 117(4), 231-6.
Stemper B, et al. Effects of Vagus Nerve Stimulation On Cardiovascular Regulation in Patients With Epilepsy. Acta Neurol Scand. 2008;117(4):231-6. PubMed PMID: 18005223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of vagus nerve stimulation on cardiovascular regulation in patients with epilepsy. AU - Stemper,B, AU - Devinsky,O, AU - Haendl,T, AU - Welsch,G, AU - Hilz,M J, Y1 - 2007/11/13/ PY - 2007/11/17/pubmed PY - 2008/4/11/medline PY - 2007/11/17/entrez SP - 231 EP - 6 JF - Acta neurologica Scandinavica JO - Acta Neurol Scand VL - 117 IS - 4 N2 - OBJECTIVE: To evaluate the impact of vagus nerve stimulation (VNS) on heart rate and blood pressure (BP) modulation in epilepsy patients. MATERIAL AND METHODS: Twenty-one epilepsy patients with VNS were tested during on (60 s) and off (5 min) phases. We monitored BP, RR intervals (RRI) and respiration. Spectral analysis was performed in low- (LF: 0.04-0.15 Hz) and high-frequency bands (HF: 0.15-0.5 Hz). For coherences above 0.5, we calculated the LF transfer function between systolic BP and RRI, and the HF transfer function gain and phase between RRI and respiration. Differences between the on and off phases were evaluated using Wilcoxon test. RESULTS: VNS did not change RRI and BP values. The LF power of BP and the LF and HF power of RRI increased significantly. There was a slight change in the RRI/BP LF gain and the RRI/respiration HF gain (ns). The HF phase between RRI and respiration decreased significantly. CONCLUSIONS: Our findings show that VNS influences both sympathetic and parasympathetic cardiovascular modulation. However, our results also show that VNS does not negatively influence autonomic cardiovascular regulation. SN - 1600-0404 UR - https://www.unboundmedicine.com/medline/citation/18005223/Effects_of_vagus_nerve_stimulation_on_cardiovascular_regulation_in_patients_with_epilepsy_ DB - PRIME DP - Unbound Medicine ER -