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Interplay between MAMP-triggered and SA-mediated defense responses.
Plant J. 2008 Mar; 53(5):763-75.PJ

Abstract

Plants respond to pathogen infection using an innate immune system with at least two distinct recognition mechanisms. One mechanism recognizes microbe-associated molecular patterns (MAMPs). The other is based on resistance (R) genes and specifically recognizes certain pathogen virulence factors, including those delivered through the type III secretion system (TTSS) of bacteria. Salicylic acid (SA)-mediated responses are an important part of the R gene-mediated defense. Substantial overlaps between MAMP-triggered and SA-mediated responses have been reported. However, interactions between MAMP-triggered and SA-mediated signaling mechanisms have not been well documented. Here we report intimate interactions between MAMP-triggered and SA-mediated signaling. We found that SA accumulated at a higher level 6 h after treatment with a MAMP, flg22 or inoculation with Pseudomonas syringae pv. tomato DC3000 (PstDC3000) hrcC mutant, which is deficient in TTSS function. Disruptions of SA signaling components, such as SID2 and PAD4, strongly affected MAMP-triggered responses monitored by expression profiling. We found two groups of genes that were induced by PstDC3000 hrcC in an SA-dependent manner. One group was SID2-dependent at all time points, whereas the other was SID2-independent at early time points and SID2-dependent at later time points. Thus, the expression of the latter genes responds to MAMPs through both SA-independent and SA-dependent signaling mechanisms. Strong resistance to PstDC3000 hrcC was dependent on SA signaling. These results indicate that the SA increase triggered by MAMPs is a major component of the MAMP-triggered signaling mechanism, explaining the overlapping spectra of MAMP-triggered and SA-mediated responses.

Authors+Show Affiliations

Department of Plant Biology, Microbial and Plant Genomics Institute, University of Minnesota, 1500 Gortner Avenue, St Paul, MN 55108, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18005228

Citation

Tsuda, Kenichi, et al. "Interplay Between MAMP-triggered and SA-mediated Defense Responses." The Plant Journal : for Cell and Molecular Biology, vol. 53, no. 5, 2008, pp. 763-75.
Tsuda K, Sato M, Glazebrook J, et al. Interplay between MAMP-triggered and SA-mediated defense responses. Plant J. 2008;53(5):763-75.
Tsuda, K., Sato, M., Glazebrook, J., Cohen, J. D., & Katagiri, F. (2008). Interplay between MAMP-triggered and SA-mediated defense responses. The Plant Journal : for Cell and Molecular Biology, 53(5), 763-75.
Tsuda K, et al. Interplay Between MAMP-triggered and SA-mediated Defense Responses. Plant J. 2008;53(5):763-75. PubMed PMID: 18005228.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interplay between MAMP-triggered and SA-mediated defense responses. AU - Tsuda,Kenichi, AU - Sato,Masanao, AU - Glazebrook,Jane, AU - Cohen,Jerry D, AU - Katagiri,Fumiaki, Y1 - 2007/11/14/ PY - 2007/11/17/pubmed PY - 2008/5/21/medline PY - 2007/11/17/entrez SP - 763 EP - 75 JF - The Plant journal : for cell and molecular biology JO - Plant J. VL - 53 IS - 5 N2 - Plants respond to pathogen infection using an innate immune system with at least two distinct recognition mechanisms. One mechanism recognizes microbe-associated molecular patterns (MAMPs). The other is based on resistance (R) genes and specifically recognizes certain pathogen virulence factors, including those delivered through the type III secretion system (TTSS) of bacteria. Salicylic acid (SA)-mediated responses are an important part of the R gene-mediated defense. Substantial overlaps between MAMP-triggered and SA-mediated responses have been reported. However, interactions between MAMP-triggered and SA-mediated signaling mechanisms have not been well documented. Here we report intimate interactions between MAMP-triggered and SA-mediated signaling. We found that SA accumulated at a higher level 6 h after treatment with a MAMP, flg22 or inoculation with Pseudomonas syringae pv. tomato DC3000 (PstDC3000) hrcC mutant, which is deficient in TTSS function. Disruptions of SA signaling components, such as SID2 and PAD4, strongly affected MAMP-triggered responses monitored by expression profiling. We found two groups of genes that were induced by PstDC3000 hrcC in an SA-dependent manner. One group was SID2-dependent at all time points, whereas the other was SID2-independent at early time points and SID2-dependent at later time points. Thus, the expression of the latter genes responds to MAMPs through both SA-independent and SA-dependent signaling mechanisms. Strong resistance to PstDC3000 hrcC was dependent on SA signaling. These results indicate that the SA increase triggered by MAMPs is a major component of the MAMP-triggered signaling mechanism, explaining the overlapping spectra of MAMP-triggered and SA-mediated responses. SN - 1365-313X UR - https://www.unboundmedicine.com/medline/citation/18005228/Interplay_between_MAMP_triggered_and_SA_mediated_defense_responses_ L2 - https://doi.org/10.1111/j.1365-313X.2007.03369.x DB - PRIME DP - Unbound Medicine ER -