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Enhancing effect of chlorinated organic solvents on histamine release and inflammatory mediator production.
Toxicology. 2008 Jan 14; 243(1-2):75-83.T

Abstract

We investigated the effect of several chlorinated organic solvents on antigen-induced histamine release and inflammatory mediator production. Non-purified rat peritoneal mast cells (NPMC) and rat basophilic leukemia (RBL-2H3) cells were sensitized with anti-dinitrophenol (DNP) monoclonal IgE antibody, and then stimulated with DNP-conjugated bovine serum albumin (DNP-BSA) and several chlorinated organic solvents. Trichloroethylene (TCE) and tetrachloroethylene (PCE) enhanced histamine release from antigen-stimulated NPMC and RBL-2H3 in a dose-dependent manner. In addition, TCE and PCE increased IL-4 and TNF-alpha production from antigen-stimulated RBL-2H3. In an in vivo study, we investigated the effect of TCE and PCE on passive cutaneous anaphylaxis (PCA) reaction. TCE and PCE enhanced PCA reaction markedly. These results suggest that TCE and PCE increase histamine release and inflammatory mediator production from antigen-stimulated mast cells via the modulation of immune responses. In addition, exposure to TCE and PCE may lead to the augmentation of allergic diseases.

Authors+Show Affiliations

Laboratory of Hygienics, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan. mkt.s.lev5060@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18006135

Citation

Seo, Makoto, et al. "Enhancing Effect of Chlorinated Organic Solvents On Histamine Release and Inflammatory Mediator Production." Toxicology, vol. 243, no. 1-2, 2008, pp. 75-83.
Seo M, Ikeda K, Okamura T, et al. Enhancing effect of chlorinated organic solvents on histamine release and inflammatory mediator production. Toxicology. 2008;243(1-2):75-83.
Seo, M., Ikeda, K., Okamura, T., Kida, K., Satoh, M., Inagaki, N., Nagai, H., & Nagase, H. (2008). Enhancing effect of chlorinated organic solvents on histamine release and inflammatory mediator production. Toxicology, 243(1-2), 75-83.
Seo M, et al. Enhancing Effect of Chlorinated Organic Solvents On Histamine Release and Inflammatory Mediator Production. Toxicology. 2008 Jan 14;243(1-2):75-83. PubMed PMID: 18006135.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhancing effect of chlorinated organic solvents on histamine release and inflammatory mediator production. AU - Seo,Makoto, AU - Ikeda,Koji, AU - Okamura,Tetsunori, AU - Kida,Kumiko, AU - Satoh,Masahiko, AU - Inagaki,Naoki, AU - Nagai,Hiroichi, AU - Nagase,Hisamitsu, Y1 - 2007/09/29/ PY - 2007/07/30/received PY - 2007/09/16/revised PY - 2007/09/24/accepted PY - 2007/11/17/pubmed PY - 2008/3/1/medline PY - 2007/11/17/entrez SP - 75 EP - 83 JF - Toxicology JO - Toxicology VL - 243 IS - 1-2 N2 - We investigated the effect of several chlorinated organic solvents on antigen-induced histamine release and inflammatory mediator production. Non-purified rat peritoneal mast cells (NPMC) and rat basophilic leukemia (RBL-2H3) cells were sensitized with anti-dinitrophenol (DNP) monoclonal IgE antibody, and then stimulated with DNP-conjugated bovine serum albumin (DNP-BSA) and several chlorinated organic solvents. Trichloroethylene (TCE) and tetrachloroethylene (PCE) enhanced histamine release from antigen-stimulated NPMC and RBL-2H3 in a dose-dependent manner. In addition, TCE and PCE increased IL-4 and TNF-alpha production from antigen-stimulated RBL-2H3. In an in vivo study, we investigated the effect of TCE and PCE on passive cutaneous anaphylaxis (PCA) reaction. TCE and PCE enhanced PCA reaction markedly. These results suggest that TCE and PCE increase histamine release and inflammatory mediator production from antigen-stimulated mast cells via the modulation of immune responses. In addition, exposure to TCE and PCE may lead to the augmentation of allergic diseases. SN - 0300-483X UR - https://www.unboundmedicine.com/medline/citation/18006135/Enhancing_effect_of_chlorinated_organic_solvents_on_histamine_release_and_inflammatory_mediator_production_ DB - PRIME DP - Unbound Medicine ER -