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Likelihood of having isolated postchallenge hyperglycemia in an Iranian urban population.
Diabetes Res Clin Pract. 2008 Mar; 79(3):490-6.DR

Abstract

To identify subjects who would most likely benefit from oral glucose tolerance test (OGTT) for diagnosis of diabetes mellitus (DM), namely isolated postchallenge hyperglycemia (IPH) (i.e. FPG<126mg/dl and 2h-PG>or=200mg/dl), we evaluated data and results of OGTT of 9745 participants of Tehran Lipid and Glucose Study (TLGS), aged >20 years and without previously diagnosed DM. The overall prevalence of IPH was 3.1% (95% CI: 2.8-3.4%, n=302). In the multivariate logistic regression analysis, the odds ratios (OR) for IPH were statistically significant for FPG>or=100mg/dl (OR 9.5; 95% CI: 7.1-12.5), age >or=40 years (OR 2.6; 95% CI: 1.8-3.7), triglycerides >or=200mg/dl (OR 2.1; 95% CI: 1.6-2.7), hypertension (OR 2.0; 95% CI: 1.5-2.6) and abnormal waist circumference (OR 1.9; 95% CI: 1.3-2.8). In subjects with FPG<126mg/dl, findings that best distinguished between IPH and non-diabetic subjects were FPG>or=100mg/dl [positive likelihood ratio (LR(+))=5.2], FPG>or=100mg/dl together with triglycerides >or=200mg/dl [LR(+)=9.7] and a combination of all the five factors [LR(+)=12.9]. This analysis showed that in Iranian urban subjects with FPG<126mg/dl, factors such as FPG>or=100mg/dl, older age, hypertriglyceridemia, hypertension and abnormal waist circumference were the best predictors of presence of IPH; OGTT would hence be recommended for opportunistic screening of IPH in subjects with above mentioned characteristics.

Authors+Show Affiliations

Obesity Research Center, Research Institute for Endocrine Sciences, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. fhospanah@erc.ac.irNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18006175

Citation

Hosseinpanah, Farhad, et al. "Likelihood of Having Isolated Postchallenge Hyperglycemia in an Iranian Urban Population." Diabetes Research and Clinical Practice, vol. 79, no. 3, 2008, pp. 490-6.
Hosseinpanah F, Rambod M, Azizi F. Likelihood of having isolated postchallenge hyperglycemia in an Iranian urban population. Diabetes Res Clin Pract. 2008;79(3):490-6.
Hosseinpanah, F., Rambod, M., & Azizi, F. (2008). Likelihood of having isolated postchallenge hyperglycemia in an Iranian urban population. Diabetes Research and Clinical Practice, 79(3), 490-6.
Hosseinpanah F, Rambod M, Azizi F. Likelihood of Having Isolated Postchallenge Hyperglycemia in an Iranian Urban Population. Diabetes Res Clin Pract. 2008;79(3):490-6. PubMed PMID: 18006175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Likelihood of having isolated postchallenge hyperglycemia in an Iranian urban population. AU - Hosseinpanah,Farhad, AU - Rambod,Mehdi, AU - Azizi,Fereidoun, Y1 - 2007/11/19/ PY - 2007/04/22/received PY - 2007/10/02/accepted PY - 2007/11/17/pubmed PY - 2008/6/28/medline PY - 2007/11/17/entrez SP - 490 EP - 6 JF - Diabetes research and clinical practice JO - Diabetes Res Clin Pract VL - 79 IS - 3 N2 - To identify subjects who would most likely benefit from oral glucose tolerance test (OGTT) for diagnosis of diabetes mellitus (DM), namely isolated postchallenge hyperglycemia (IPH) (i.e. FPG<126mg/dl and 2h-PG>or=200mg/dl), we evaluated data and results of OGTT of 9745 participants of Tehran Lipid and Glucose Study (TLGS), aged >20 years and without previously diagnosed DM. The overall prevalence of IPH was 3.1% (95% CI: 2.8-3.4%, n=302). In the multivariate logistic regression analysis, the odds ratios (OR) for IPH were statistically significant for FPG>or=100mg/dl (OR 9.5; 95% CI: 7.1-12.5), age >or=40 years (OR 2.6; 95% CI: 1.8-3.7), triglycerides >or=200mg/dl (OR 2.1; 95% CI: 1.6-2.7), hypertension (OR 2.0; 95% CI: 1.5-2.6) and abnormal waist circumference (OR 1.9; 95% CI: 1.3-2.8). In subjects with FPG<126mg/dl, findings that best distinguished between IPH and non-diabetic subjects were FPG>or=100mg/dl [positive likelihood ratio (LR(+))=5.2], FPG>or=100mg/dl together with triglycerides >or=200mg/dl [LR(+)=9.7] and a combination of all the five factors [LR(+)=12.9]. This analysis showed that in Iranian urban subjects with FPG<126mg/dl, factors such as FPG>or=100mg/dl, older age, hypertriglyceridemia, hypertension and abnormal waist circumference were the best predictors of presence of IPH; OGTT would hence be recommended for opportunistic screening of IPH in subjects with above mentioned characteristics. SN - 1872-8227 UR - https://www.unboundmedicine.com/medline/citation/18006175/Likelihood_of_having_isolated_postchallenge_hyperglycemia_in_an_Iranian_urban_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(07)00521-9 DB - PRIME DP - Unbound Medicine ER -