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Acute hepatitis C in a contemporary US cohort: modes of acquisition and factors influencing viral clearance.
J Infect Dis 2007; 196(10):1474-82JI

Abstract

BACKGROUND

Acute hepatitis C virus (HCV) infection is often asymptomatic; thus, its epidemiology and natural history are difficult to define.

METHODS

Acute HCV infection was identified on the basis of HCV seroconversion within 1 year (n=45), new anti-HCV seropositivity with clinical acute hepatitis (n=21), or HCV strain sequencing after an iatrogenic exposure (n=1). Risk factors were assessed with a baseline questionnaire, and participants were followed up prospectively with serial measurement of viral loads.

RESULTS

Of 67 persons with acute HCV infection, most were asymptomatic (64%) and injection drug users (66%). Thirteen had an unknown mode of transmission; of these, 11 reported high-risk sexual behavior. Ten acquired acute HCV infection within 3 months of an iatrogenic exposure; 3 had confirmed iatrogenic infection, and 4 had no other risk factors identified. The spontaneous viral clearance rate after 6 months of infection was 18% (95% confidence interval, 11%-31%). The rate of viral clearance varied significantly by sex (34% vs. 3% for women vs. men; P<.001).

CONCLUSIONS

High-risk sexual or iatrogenic exposures may be important contemporary risk factors for HCV infection. The spontaneous viral clearance rate (18%) in this contemporary study was similar to that reported for past studies of transfusion-associated HCV infection. Women were more likely to clear acute HCV infection than men.

Authors+Show Affiliations

Department of Medicine, Division of Infectious Diseases, University of Washington, 325 Ninth Avenue, Seattle, WA 98104, USA. chiaw@u.washington.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18008226

Citation

Wang, Chia C., et al. "Acute Hepatitis C in a Contemporary US Cohort: Modes of Acquisition and Factors Influencing Viral Clearance." The Journal of Infectious Diseases, vol. 196, no. 10, 2007, pp. 1474-82.
Wang CC, Krantz E, Klarquist J, et al. Acute hepatitis C in a contemporary US cohort: modes of acquisition and factors influencing viral clearance. J Infect Dis. 2007;196(10):1474-82.
Wang, C. C., Krantz, E., Klarquist, J., Krows, M., McBride, L., Scott, E. P., ... Rosen, H. R. (2007). Acute hepatitis C in a contemporary US cohort: modes of acquisition and factors influencing viral clearance. The Journal of Infectious Diseases, 196(10), pp. 1474-82.
Wang CC, et al. Acute Hepatitis C in a Contemporary US Cohort: Modes of Acquisition and Factors Influencing Viral Clearance. J Infect Dis. 2007 Nov 15;196(10):1474-82. PubMed PMID: 18008226.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute hepatitis C in a contemporary US cohort: modes of acquisition and factors influencing viral clearance. AU - Wang,Chia C, AU - Krantz,Elizabeth, AU - Klarquist,Jared, AU - Krows,Meighan, AU - McBride,Lanamarie, AU - Scott,Edward P, AU - Shaw-Stiffel,Thomas, AU - Weston,Scott J, AU - Thiede,Hanne, AU - Wald,Anna, AU - Rosen,Hugo R, Y1 - 2007/10/31/ PY - 2007/04/13/received PY - 2007/06/01/accepted PY - 2007/11/17/pubmed PY - 2008/1/12/medline PY - 2007/11/17/entrez SP - 1474 EP - 82 JF - The Journal of infectious diseases JO - J. Infect. Dis. VL - 196 IS - 10 N2 - BACKGROUND: Acute hepatitis C virus (HCV) infection is often asymptomatic; thus, its epidemiology and natural history are difficult to define. METHODS: Acute HCV infection was identified on the basis of HCV seroconversion within 1 year (n=45), new anti-HCV seropositivity with clinical acute hepatitis (n=21), or HCV strain sequencing after an iatrogenic exposure (n=1). Risk factors were assessed with a baseline questionnaire, and participants were followed up prospectively with serial measurement of viral loads. RESULTS: Of 67 persons with acute HCV infection, most were asymptomatic (64%) and injection drug users (66%). Thirteen had an unknown mode of transmission; of these, 11 reported high-risk sexual behavior. Ten acquired acute HCV infection within 3 months of an iatrogenic exposure; 3 had confirmed iatrogenic infection, and 4 had no other risk factors identified. The spontaneous viral clearance rate after 6 months of infection was 18% (95% confidence interval, 11%-31%). The rate of viral clearance varied significantly by sex (34% vs. 3% for women vs. men; P<.001). CONCLUSIONS: High-risk sexual or iatrogenic exposures may be important contemporary risk factors for HCV infection. The spontaneous viral clearance rate (18%) in this contemporary study was similar to that reported for past studies of transfusion-associated HCV infection. Women were more likely to clear acute HCV infection than men. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/18008226/Acute_hepatitis_C_in_a_contemporary_US_cohort:_modes_of_acquisition_and_factors_influencing_viral_clearance_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/522608 DB - PRIME DP - Unbound Medicine ER -