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Long-term effect of pneumococcal conjugate vaccine on nasopharyngeal colonization by Streptococcus pneumoniae--and associated interactions with Staphylococcus aureus and Haemophilus influenzae colonization--in HIV-Infected and HIV-uninfected children.
J Infect Dis. 2007 Dec 01; 196(11):1662-6.JI

Abstract

After a primary series of 3 doses, it was found that a 9-valent pneumococcal conjugate vaccine no longer reduces nasopharyngeal colonization by vaccine serotypes in children 5.3 years of age. In addition, human immunodeficiency virus (HIV)-infected children (n=81) had a higher prevalence of colonization by Streptococcus pneumoniae and Haemophilus influenzae (71.6% and 74.1%, respectively) than did HIV-uninfected children (n=271; 50.9% and 52.0%, respectively), suggesting that increased colonization may contribute to the greater burden of pneumococcal disease in HIV-infected children. Inverse associations between colonization by S. pneumoniae and colonization by Staphylococcus aureus and between colonization by S. aureus and colonization by H. influenzae were observed only in HIV-uninfected children, possibly as a result of suboptimal adaptive immunity after previous colonization in HIV-infected children.

Authors+Show Affiliations

University of the Witwatersrand/Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, Bertsham, South Africa. madhis@hivsa.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18008250

Citation

Madhi, Shabir A., et al. "Long-term Effect of Pneumococcal Conjugate Vaccine On Nasopharyngeal Colonization By Streptococcus Pneumoniae--and Associated Interactions With Staphylococcus Aureus and Haemophilus Influenzae Colonization--in HIV-Infected and HIV-uninfected Children." The Journal of Infectious Diseases, vol. 196, no. 11, 2007, pp. 1662-6.
Madhi SA, Adrian P, Kuwanda L, et al. Long-term effect of pneumococcal conjugate vaccine on nasopharyngeal colonization by Streptococcus pneumoniae--and associated interactions with Staphylococcus aureus and Haemophilus influenzae colonization--in HIV-Infected and HIV-uninfected children. J Infect Dis. 2007;196(11):1662-6.
Madhi, S. A., Adrian, P., Kuwanda, L., Cutland, C., Albrich, W. C., & Klugman, K. P. (2007). Long-term effect of pneumococcal conjugate vaccine on nasopharyngeal colonization by Streptococcus pneumoniae--and associated interactions with Staphylococcus aureus and Haemophilus influenzae colonization--in HIV-Infected and HIV-uninfected children. The Journal of Infectious Diseases, 196(11), 1662-6.
Madhi SA, et al. Long-term Effect of Pneumococcal Conjugate Vaccine On Nasopharyngeal Colonization By Streptococcus Pneumoniae--and Associated Interactions With Staphylococcus Aureus and Haemophilus Influenzae Colonization--in HIV-Infected and HIV-uninfected Children. J Infect Dis. 2007 Dec 1;196(11):1662-6. PubMed PMID: 18008250.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term effect of pneumococcal conjugate vaccine on nasopharyngeal colonization by Streptococcus pneumoniae--and associated interactions with Staphylococcus aureus and Haemophilus influenzae colonization--in HIV-Infected and HIV-uninfected children. AU - Madhi,Shabir A, AU - Adrian,Peter, AU - Kuwanda,Locadiah, AU - Cutland,Clare, AU - Albrich,Werner C, AU - Klugman,Keith P, Y1 - 2007/10/25/ PY - 2007/05/31/received PY - 2007/06/19/accepted PY - 2007/11/17/pubmed PY - 2007/12/29/medline PY - 2007/11/17/entrez SP - 1662 EP - 6 JF - The Journal of infectious diseases JO - J Infect Dis VL - 196 IS - 11 N2 - After a primary series of 3 doses, it was found that a 9-valent pneumococcal conjugate vaccine no longer reduces nasopharyngeal colonization by vaccine serotypes in children 5.3 years of age. In addition, human immunodeficiency virus (HIV)-infected children (n=81) had a higher prevalence of colonization by Streptococcus pneumoniae and Haemophilus influenzae (71.6% and 74.1%, respectively) than did HIV-uninfected children (n=271; 50.9% and 52.0%, respectively), suggesting that increased colonization may contribute to the greater burden of pneumococcal disease in HIV-infected children. Inverse associations between colonization by S. pneumoniae and colonization by Staphylococcus aureus and between colonization by S. aureus and colonization by H. influenzae were observed only in HIV-uninfected children, possibly as a result of suboptimal adaptive immunity after previous colonization in HIV-infected children. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/18008250/Long_term_effect_of_pneumococcal_conjugate_vaccine_on_nasopharyngeal_colonization_by_Streptococcus_pneumoniae__and_associated_interactions_with_Staphylococcus_aureus_and_Haemophilus_influenzae_colonization__in_HIV_Infected_and_HIV_uninfected_children_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/522164 DB - PRIME DP - Unbound Medicine ER -