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Cellular and humoral responses to influenza in gabonese children living in rural and semi-urban areas.
J Infect Dis 2007; 196(11):1671-8JI

Abstract

BACKGROUND

With the current attention to the pandemic threat of avian influenza viruses, it is recognized that there is little information on influenza in Africa. In addition, the effects of influenza vaccination in African countries could be very different from the effects in regions with less exposure to microorganisms and parasites.

METHODS

To monitor the presence of influenza viruses and investigate the immunological responses to influenza vaccination, schoolchildren in semi-urban and rural regions of Gabon were studied. Influenza-specific antibody responses to the 3 strains represented in the vaccine were determined in the serum. Furthermore, cytokine responses were measured after in vitro stimulation of whole blood by influenza antigens, before and after vaccination.

RESULTS

Prevaccination titers of antibody against H3N2 were high. At vaccination, the titers of antibody against the 3 influenza strains increased significantly. The anti-H1N1 and anti-B responses after vaccination were weaker in rural schoolchildren than in semi-urban schoolchildren. Influenza-specific cytokine responses were induced within a week, showing significantly lower interferon- gamma and significantly higher interleukin-5 in the children from rural areas.

CONCLUSIONS

Prevaccination antibody levels indicated that influenza viruses circulate in Gabon. Altogether, influenza vaccination induces weaker immune responses in a rural population than in a semi-urban population of Gabonese schoolchildren.

Authors+Show Affiliations

Department of Parasitology, Leiden University Medical Center, Leiden, Leiden, 2300 RC, The Netherlands. evanriet@lacdr.leidenuniv.nl.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18008252

Citation

van Riet, E, et al. "Cellular and Humoral Responses to Influenza in Gabonese Children Living in Rural and Semi-urban Areas." The Journal of Infectious Diseases, vol. 196, no. 11, 2007, pp. 1671-8.
van Riet E, Adegnika AA, Retra K, et al. Cellular and humoral responses to influenza in gabonese children living in rural and semi-urban areas. J Infect Dis. 2007;196(11):1671-8.
van Riet, E., Adegnika, A. A., Retra, K., Vieira, R., Tielens, A. G., Lell, B., ... Yazdanbakhsh, M. (2007). Cellular and humoral responses to influenza in gabonese children living in rural and semi-urban areas. The Journal of Infectious Diseases, 196(11), pp. 1671-8.
van Riet E, et al. Cellular and Humoral Responses to Influenza in Gabonese Children Living in Rural and Semi-urban Areas. J Infect Dis. 2007 Dec 1;196(11):1671-8. PubMed PMID: 18008252.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cellular and humoral responses to influenza in gabonese children living in rural and semi-urban areas. AU - van Riet,E, AU - Adegnika,A A, AU - Retra,K, AU - Vieira,R, AU - Tielens,A G M, AU - Lell,B, AU - Issifou,S, AU - Hartgers,F C, AU - Rimmelzwaan,G F, AU - Kremsner,P G, AU - Yazdanbakhsh,M, Y1 - 2007/10/25/ PY - 2007/03/15/received PY - 2007/05/31/accepted PY - 2007/11/17/pubmed PY - 2007/12/29/medline PY - 2007/11/17/entrez SP - 1671 EP - 8 JF - The Journal of infectious diseases JO - J. Infect. Dis. VL - 196 IS - 11 N2 - BACKGROUND: With the current attention to the pandemic threat of avian influenza viruses, it is recognized that there is little information on influenza in Africa. In addition, the effects of influenza vaccination in African countries could be very different from the effects in regions with less exposure to microorganisms and parasites. METHODS: To monitor the presence of influenza viruses and investigate the immunological responses to influenza vaccination, schoolchildren in semi-urban and rural regions of Gabon were studied. Influenza-specific antibody responses to the 3 strains represented in the vaccine were determined in the serum. Furthermore, cytokine responses were measured after in vitro stimulation of whole blood by influenza antigens, before and after vaccination. RESULTS: Prevaccination titers of antibody against H3N2 were high. At vaccination, the titers of antibody against the 3 influenza strains increased significantly. The anti-H1N1 and anti-B responses after vaccination were weaker in rural schoolchildren than in semi-urban schoolchildren. Influenza-specific cytokine responses were induced within a week, showing significantly lower interferon- gamma and significantly higher interleukin-5 in the children from rural areas. CONCLUSIONS: Prevaccination antibody levels indicated that influenza viruses circulate in Gabon. Altogether, influenza vaccination induces weaker immune responses in a rural population than in a semi-urban population of Gabonese schoolchildren. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/18008252/Cellular_and_humoral_responses_to_influenza_in_gabonese_children_living_in_rural_and_semi_urban_areas_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/522010 DB - PRIME DP - Unbound Medicine ER -