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Oral administration of chicken breast extract increases brain carnosine and anserine concentrations in rats.
Nutr Neurosci. 2007 Jun-Aug; 10(3-4):181-6.NN

Abstract

Carnosine (beta-alanyl-L-histidine) and its derivative anserine (beta-alanyl-1-methyl-L-histidine) are antioxidants and putative neurotransmitters in the brain. These dipeptides are rich in the commercially available supplement chicken breast extract (CBEX). To clarify the effects of CBEX on the brain, we examined whether single oral administration of CBEX (20 ml/kg) affects brain dipeptide and free amino acid concentrations in male Wistar rats. CBEX significantly and time-dependently increased carnosine and anserine levels in the plasma (at 120 min after injection, increase rates were 2976 and 4142%, respectively), hippocampus (64 and 78%), and hypothalamus (188 and 120%), but not in cerebral cortex. Significant and time-dependent increases in citrulline in the hippocampus (49%) and hypothalamus (41%) demonstrated generation of nitric oxide due to the increased carnosine and/or anserine levels in these brain regions. These findings suggest that CBEX modifies brain functions by increasing levels of these dipeptides.

Authors+Show Affiliations

Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Higashi-ku, Fukuoka-shi, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18019400

Citation

Tomonaga, Shozo, et al. "Oral Administration of Chicken Breast Extract Increases Brain Carnosine and Anserine Concentrations in Rats." Nutritional Neuroscience, vol. 10, no. 3-4, 2007, pp. 181-6.
Tomonaga S, Hayakawa T, Yamane H, et al. Oral administration of chicken breast extract increases brain carnosine and anserine concentrations in rats. Nutr Neurosci. 2007;10(3-4):181-6.
Tomonaga, S., Hayakawa, T., Yamane, H., Maemura, H., Sato, M., Takahata, Y., Morimatsu, F., & Furuse, M. (2007). Oral administration of chicken breast extract increases brain carnosine and anserine concentrations in rats. Nutritional Neuroscience, 10(3-4), 181-6.
Tomonaga S, et al. Oral Administration of Chicken Breast Extract Increases Brain Carnosine and Anserine Concentrations in Rats. Nutr Neurosci. 2007 Jun-Aug;10(3-4):181-6. PubMed PMID: 18019400.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral administration of chicken breast extract increases brain carnosine and anserine concentrations in rats. AU - Tomonaga,Shozo, AU - Hayakawa,Toru, AU - Yamane,Haruka, AU - Maemura,Hirohiko, AU - Sato,Mikako, AU - Takahata,Yoshihisa, AU - Morimatsu,Fumiki, AU - Furuse,Mitsuhiro, PY - 2007/11/21/pubmed PY - 2008/1/19/medline PY - 2007/11/21/entrez SP - 181 EP - 6 JF - Nutritional neuroscience JO - Nutr Neurosci VL - 10 IS - 3-4 N2 - Carnosine (beta-alanyl-L-histidine) and its derivative anserine (beta-alanyl-1-methyl-L-histidine) are antioxidants and putative neurotransmitters in the brain. These dipeptides are rich in the commercially available supplement chicken breast extract (CBEX). To clarify the effects of CBEX on the brain, we examined whether single oral administration of CBEX (20 ml/kg) affects brain dipeptide and free amino acid concentrations in male Wistar rats. CBEX significantly and time-dependently increased carnosine and anserine levels in the plasma (at 120 min after injection, increase rates were 2976 and 4142%, respectively), hippocampus (64 and 78%), and hypothalamus (188 and 120%), but not in cerebral cortex. Significant and time-dependent increases in citrulline in the hippocampus (49%) and hypothalamus (41%) demonstrated generation of nitric oxide due to the increased carnosine and/or anserine levels in these brain regions. These findings suggest that CBEX modifies brain functions by increasing levels of these dipeptides. SN - 1028-415X UR - https://www.unboundmedicine.com/medline/citation/18019400/Oral_administration_of_chicken_breast_extract_increases_brain_carnosine_and_anserine_concentrations_in_rats_ L2 - https://www.tandfonline.com/doi/full/10.1080/10284150701587338 DB - PRIME DP - Unbound Medicine ER -