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Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21.
Pediatr Neurol 2007; 37(6):398-403PN

Abstract

Endogenous coenzyme Q10 is an essential cofactor in the mitochondrial respiratory chain, a potent antioxidant, and a potential biomarker for systemic oxidative status. Evidence of oxidative stress was reported in individuals with trisomy 21. In this study, 14 children with trisomy 21 had significantly increased (P < 0.0001) plasma ubiquinone-10 (the oxidized component of coenzyme Q10) compared with 12 age- and sex-matched healthy children (historical controls). Also, the mean ratio of ubiquinol-10 (the biochemically reduced component):total coenzyme Q10 was significantly decreased (P < 0.0001). After 3 months of ubiquinol-10 supplementation (10 mg/kg/day) to 10 patients with trisomy 21, the mean ubiquinol-10:total coenzyme Q10 ratio increased significantly (P < 0.0001) above baseline values, and 80% of individual ratios were within normal range. No significant or unexpected adverse effects were reported by participants. To our knowledge, this is the first study to indicate that the pro-oxidant state in plasma of children with trisomy 21, as assessed by ubiquinol-10:total coenzyme Q10 ratio, may be normalized with ubiquinol-10 supplementation. Further studies are needed to determine whether correction of this oxidant imbalance improves clinical outcomes of children with trisomy 21.

Authors+Show Affiliations

Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center and University of Cincinnati Medical Center, Cincinnati, OH 45229-3039, USA. michael.miles@cchmc.org

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18021919

Citation

Miles, Michael V., et al. "Coenzyme Q10 (ubiquinol-10) Supplementation Improves Oxidative Imbalance in Children With Trisomy 21." Pediatric Neurology, vol. 37, no. 6, 2007, pp. 398-403.
Miles MV, Patterson BJ, Chalfonte-Evans ML, et al. Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21. Pediatr Neurol. 2007;37(6):398-403.
Miles, M. V., Patterson, B. J., Chalfonte-Evans, M. L., Horn, P. S., Hickey, F. J., Schapiro, M. B., ... Hotze, S. L. (2007). Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21. Pediatric Neurology, 37(6), pp. 398-403.
Miles MV, et al. Coenzyme Q10 (ubiquinol-10) Supplementation Improves Oxidative Imbalance in Children With Trisomy 21. Pediatr Neurol. 2007;37(6):398-403. PubMed PMID: 18021919.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21. AU - Miles,Michael V, AU - Patterson,Bonnie J, AU - Chalfonte-Evans,Melinda L, AU - Horn,Paul S, AU - Hickey,Francis J, AU - Schapiro,Mark B, AU - Steele,Paul E, AU - Tang,Peter H, AU - Hotze,Stephanie L, PY - 2007/04/10/received PY - 2007/05/14/revised PY - 2007/08/13/accepted PY - 2007/11/21/pubmed PY - 2008/2/15/medline PY - 2007/11/21/entrez SP - 398 EP - 403 JF - Pediatric neurology JO - Pediatr. Neurol. VL - 37 IS - 6 N2 - Endogenous coenzyme Q10 is an essential cofactor in the mitochondrial respiratory chain, a potent antioxidant, and a potential biomarker for systemic oxidative status. Evidence of oxidative stress was reported in individuals with trisomy 21. In this study, 14 children with trisomy 21 had significantly increased (P < 0.0001) plasma ubiquinone-10 (the oxidized component of coenzyme Q10) compared with 12 age- and sex-matched healthy children (historical controls). Also, the mean ratio of ubiquinol-10 (the biochemically reduced component):total coenzyme Q10 was significantly decreased (P < 0.0001). After 3 months of ubiquinol-10 supplementation (10 mg/kg/day) to 10 patients with trisomy 21, the mean ubiquinol-10:total coenzyme Q10 ratio increased significantly (P < 0.0001) above baseline values, and 80% of individual ratios were within normal range. No significant or unexpected adverse effects were reported by participants. To our knowledge, this is the first study to indicate that the pro-oxidant state in plasma of children with trisomy 21, as assessed by ubiquinol-10:total coenzyme Q10 ratio, may be normalized with ubiquinol-10 supplementation. Further studies are needed to determine whether correction of this oxidant imbalance improves clinical outcomes of children with trisomy 21. SN - 0887-8994 UR - https://www.unboundmedicine.com/medline/citation/18021919/Coenzyme_Q10__ubiquinol_10__supplementation_improves_oxidative_imbalance_in_children_with_trisomy_21_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0887-8994(07)00389-X DB - PRIME DP - Unbound Medicine ER -