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Efficacy and safety of a single-dose veterinary preparation of ivermectin versus 7-day high-dose albendazole for chronic strongyloidiasis.
Int J Antimicrob Agents. 2008 Jan; 31(1):46-9.IJ

Abstract

A prospective, randomised, open study compared a 7-day course of oral albendazole 800 mg daily with a single oral dose of the parenteral veterinary preparation of ivermectin in 42 Thai patients with chronic strongyloidiasis (21 in each group). The primary endpoints were relief of symptoms (if present) and clearance of Strongyloides larvae from faeces immediately after treatment and at follow-up to 16 weeks later. Cure rates in the albendazole and ivermectin groups were 38.1% and 76.2%, respectively, (P=0.029) in the intention-to-treat analysis and 50% and 88.9%, respectively, (P=0.023) in the per-protocol analysis. Acute generalised exanthematous pustulosis developed in one patient who was treated with the veterinary preparation of ivermectin. This study confirms the superiority of ivermectin compared with albendazole as well as that oral use of the parenteral veterinary preparation in humans is as effective and safe as human preparations.

Authors+Show Affiliations

Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand. siysp@mahidol.ac.thNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18023151

Citation

Suputtamongkol, Yupin, et al. "Efficacy and Safety of a Single-dose Veterinary Preparation of Ivermectin Versus 7-day High-dose Albendazole for Chronic Strongyloidiasis." International Journal of Antimicrobial Agents, vol. 31, no. 1, 2008, pp. 46-9.
Suputtamongkol Y, Kungpanichkul N, Silpasakorn S, et al. Efficacy and safety of a single-dose veterinary preparation of ivermectin versus 7-day high-dose albendazole for chronic strongyloidiasis. Int J Antimicrob Agents. 2008;31(1):46-9.
Suputtamongkol, Y., Kungpanichkul, N., Silpasakorn, S., & Beeching, N. J. (2008). Efficacy and safety of a single-dose veterinary preparation of ivermectin versus 7-day high-dose albendazole for chronic strongyloidiasis. International Journal of Antimicrobial Agents, 31(1), 46-9.
Suputtamongkol Y, et al. Efficacy and Safety of a Single-dose Veterinary Preparation of Ivermectin Versus 7-day High-dose Albendazole for Chronic Strongyloidiasis. Int J Antimicrob Agents. 2008;31(1):46-9. PubMed PMID: 18023151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy and safety of a single-dose veterinary preparation of ivermectin versus 7-day high-dose albendazole for chronic strongyloidiasis. AU - Suputtamongkol,Yupin, AU - Kungpanichkul,Nuntakorn, AU - Silpasakorn,Saowaluk, AU - Beeching,Nicholas J, Y1 - 2007/11/26/ PY - 2007/04/30/received PY - 2007/08/22/revised PY - 2007/08/22/accepted PY - 2007/11/21/pubmed PY - 2008/3/18/medline PY - 2007/11/21/entrez SP - 46 EP - 9 JF - International journal of antimicrobial agents JO - Int J Antimicrob Agents VL - 31 IS - 1 N2 - A prospective, randomised, open study compared a 7-day course of oral albendazole 800 mg daily with a single oral dose of the parenteral veterinary preparation of ivermectin in 42 Thai patients with chronic strongyloidiasis (21 in each group). The primary endpoints were relief of symptoms (if present) and clearance of Strongyloides larvae from faeces immediately after treatment and at follow-up to 16 weeks later. Cure rates in the albendazole and ivermectin groups were 38.1% and 76.2%, respectively, (P=0.029) in the intention-to-treat analysis and 50% and 88.9%, respectively, (P=0.023) in the per-protocol analysis. Acute generalised exanthematous pustulosis developed in one patient who was treated with the veterinary preparation of ivermectin. This study confirms the superiority of ivermectin compared with albendazole as well as that oral use of the parenteral veterinary preparation in humans is as effective and safe as human preparations. SN - 0924-8579 UR - https://www.unboundmedicine.com/medline/citation/18023151/Efficacy_and_safety_of_a_single_dose_veterinary_preparation_of_ivermectin_versus_7_day_high_dose_albendazole_for_chronic_strongyloidiasis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0924-8579(07)00447-5 DB - PRIME DP - Unbound Medicine ER -