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Studies of gastric mucosa regeneration and safety promoted by Mouriri pusa treatment in acetic acid ulcer model.
J Ethnopharmacol. 2008 Jan 17; 115(2):293-301.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Mouriri pusa Gardn. (Melastomataceae) is a medicinal plant commonly used by people living in the Cerrado to treat gastrointestinal disturbances. This medicinal plant has shown intense gastroprotective action in rodent gastric lesion, but still there are no data about its healing effect on gastric mucosa.

AIM OF THE STUDY

To evaluate the methanolic extract (MeOH) obtained from Mouriri pusa leaves for its effect on the cicatrisation process of gastric ulcer.

MATERIALS AND METHODS

The healing effects on gastric ulcers inducted by subserosal injection of acetic acid were evaluated by macroscopic and microscopic measures, immunohistochemistry and cell counting in rats treated with MeOH extract of Mouriri pusa (250 mg/kg, p.o./daily) for 14 or 30 days. The toxicity of Mouriri pusa was also evaluated by body and organ weight measure and clinical biochemical parameters.

RESULTS

Mouriri pusa treatments lasting 14 and 30 days showed elevated mucus secretion (PAS) and thicker regenerative gastric mucosa, denoting increased cell proliferation, which was confirmed by PCNA immunohistochemical analysis. Moreover, there was important cell recruitment (neutrophils and mast cells) to the site of the ulcer, which is an important factor in ulcer healing. No toxic effect was observed in all parameters evaluated. Phenolic compounds present in the MeOH extract like tannins, flavonoids and epicatechin are the probable agents involved in the healing effects of this medicinal plant.

CONCLUSIONS

These findings showed a potential effect of Mouriri pusa in increasing regeneration of damaged gastric mucosa with safety for human use.

Authors+Show Affiliations

Departmento de Morfologia, Instituto de Biociências, Universidade Estadual Paulista, Rubião Junior s/n, Botucatu, SP, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18023306

Citation

Vasconcelos, P C P., et al. "Studies of Gastric Mucosa Regeneration and Safety Promoted By Mouriri Pusa Treatment in Acetic Acid Ulcer Model." Journal of Ethnopharmacology, vol. 115, no. 2, 2008, pp. 293-301.
Vasconcelos PC, Kushima H, Andreo M, et al. Studies of gastric mucosa regeneration and safety promoted by Mouriri pusa treatment in acetic acid ulcer model. J Ethnopharmacol. 2008;115(2):293-301.
Vasconcelos, P. C., Kushima, H., Andreo, M., Hiruma-Lima, C. A., Vilegas, W., Takahira, R. K., & Pellizzon, C. H. (2008). Studies of gastric mucosa regeneration and safety promoted by Mouriri pusa treatment in acetic acid ulcer model. Journal of Ethnopharmacology, 115(2), 293-301.
Vasconcelos PC, et al. Studies of Gastric Mucosa Regeneration and Safety Promoted By Mouriri Pusa Treatment in Acetic Acid Ulcer Model. J Ethnopharmacol. 2008 Jan 17;115(2):293-301. PubMed PMID: 18023306.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Studies of gastric mucosa regeneration and safety promoted by Mouriri pusa treatment in acetic acid ulcer model. AU - Vasconcelos,P C P, AU - Kushima,H, AU - Andreo,M, AU - Hiruma-Lima,C A, AU - Vilegas,W, AU - Takahira,R K, AU - Pellizzon,C H, Y1 - 2007/10/10/ PY - 2007/06/23/received PY - 2007/10/02/revised PY - 2007/10/03/accepted PY - 2007/11/21/pubmed PY - 2008/4/23/medline PY - 2007/11/21/entrez SP - 293 EP - 301 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 115 IS - 2 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Mouriri pusa Gardn. (Melastomataceae) is a medicinal plant commonly used by people living in the Cerrado to treat gastrointestinal disturbances. This medicinal plant has shown intense gastroprotective action in rodent gastric lesion, but still there are no data about its healing effect on gastric mucosa. AIM OF THE STUDY: To evaluate the methanolic extract (MeOH) obtained from Mouriri pusa leaves for its effect on the cicatrisation process of gastric ulcer. MATERIALS AND METHODS: The healing effects on gastric ulcers inducted by subserosal injection of acetic acid were evaluated by macroscopic and microscopic measures, immunohistochemistry and cell counting in rats treated with MeOH extract of Mouriri pusa (250 mg/kg, p.o./daily) for 14 or 30 days. The toxicity of Mouriri pusa was also evaluated by body and organ weight measure and clinical biochemical parameters. RESULTS: Mouriri pusa treatments lasting 14 and 30 days showed elevated mucus secretion (PAS) and thicker regenerative gastric mucosa, denoting increased cell proliferation, which was confirmed by PCNA immunohistochemical analysis. Moreover, there was important cell recruitment (neutrophils and mast cells) to the site of the ulcer, which is an important factor in ulcer healing. No toxic effect was observed in all parameters evaluated. Phenolic compounds present in the MeOH extract like tannins, flavonoids and epicatechin are the probable agents involved in the healing effects of this medicinal plant. CONCLUSIONS: These findings showed a potential effect of Mouriri pusa in increasing regeneration of damaged gastric mucosa with safety for human use. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/18023306/Studies_of_gastric_mucosa_regeneration_and_safety_promoted_by_Mouriri_pusa_treatment_in_acetic_acid_ulcer_model_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(07)00530-2 DB - PRIME DP - Unbound Medicine ER -