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Impact of hepatitis B virus (HBV) X gene integration in liver tissue on hepatocellular carcinoma development in serologically HBV-negative chronic hepatitis C patients.
J Hepatol. 2008 Jan; 48(1):43-50.JH

Abstract

BACKGROUND/AIMS

We analyzed hepatitis B virus (HBV) X gene integration in hepatocytes of HBV-negative, chronic hepatitis C (CH-C) patients with mild fibrosis, and prospectively followed these patients for the development of hepatocellular carcinoma (HCC).

METHODS

The study included 39 HBV-negative CH-C patients with mild fibrosis. HBV-X integration was determined by Alu-PCR analysis of liver specimens obtained by fine-needle biopsy.

RESULTS

Integration of HBV-X gene sequence into liver genome occurred in 9 of the 39 patients. Six of the 39 patients developed HCC during the 12-year follow-up period. No significant difference was found in the incidence of HCC between patients with and without HBV-X integration. However, the two patients with HBV-X integration who developed HCC did not have cirrhosis at the time when HCC was diagnosed, whereas the four patients without HBV-X integration who developed HCC did have cirrhosis.

CONCLUSIONS

Our findings suggest that HBV-X integration detected at the mild fibrosis stage might not indicate a high risk for HCC. HBV-X integration may be associated with HCC development in the absence of cirrhosis. However, we did not find evidence that HBV-X integration directly plays a role in hepatocarcinogenesis in CH-C patients. Further studies will be needed to clarify this point.

Authors+Show Affiliations

Department of Gastroenterology, Ogaki Municipal Hospital, Gifu, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18023912

Citation

Toyoda, Hidenori, et al. "Impact of Hepatitis B Virus (HBV) X Gene Integration in Liver Tissue On Hepatocellular Carcinoma Development in Serologically HBV-negative Chronic Hepatitis C Patients." Journal of Hepatology, vol. 48, no. 1, 2008, pp. 43-50.
Toyoda H, Kumada T, Kaneoka Y, et al. Impact of hepatitis B virus (HBV) X gene integration in liver tissue on hepatocellular carcinoma development in serologically HBV-negative chronic hepatitis C patients. J Hepatol. 2008;48(1):43-50.
Toyoda, H., Kumada, T., Kaneoka, Y., & Murakami, Y. (2008). Impact of hepatitis B virus (HBV) X gene integration in liver tissue on hepatocellular carcinoma development in serologically HBV-negative chronic hepatitis C patients. Journal of Hepatology, 48(1), 43-50.
Toyoda H, et al. Impact of Hepatitis B Virus (HBV) X Gene Integration in Liver Tissue On Hepatocellular Carcinoma Development in Serologically HBV-negative Chronic Hepatitis C Patients. J Hepatol. 2008;48(1):43-50. PubMed PMID: 18023912.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of hepatitis B virus (HBV) X gene integration in liver tissue on hepatocellular carcinoma development in serologically HBV-negative chronic hepatitis C patients. AU - Toyoda,Hidenori, AU - Kumada,Takashi, AU - Kaneoka,Yuji, AU - Murakami,Yoshiki, Y1 - 2007/10/24/ PY - 2007/03/28/received PY - 2007/08/05/revised PY - 2007/08/08/accepted PY - 2007/11/21/pubmed PY - 2008/3/12/medline PY - 2007/11/21/entrez SP - 43 EP - 50 JF - Journal of hepatology JO - J. Hepatol. VL - 48 IS - 1 N2 - BACKGROUND/AIMS: We analyzed hepatitis B virus (HBV) X gene integration in hepatocytes of HBV-negative, chronic hepatitis C (CH-C) patients with mild fibrosis, and prospectively followed these patients for the development of hepatocellular carcinoma (HCC). METHODS: The study included 39 HBV-negative CH-C patients with mild fibrosis. HBV-X integration was determined by Alu-PCR analysis of liver specimens obtained by fine-needle biopsy. RESULTS: Integration of HBV-X gene sequence into liver genome occurred in 9 of the 39 patients. Six of the 39 patients developed HCC during the 12-year follow-up period. No significant difference was found in the incidence of HCC between patients with and without HBV-X integration. However, the two patients with HBV-X integration who developed HCC did not have cirrhosis at the time when HCC was diagnosed, whereas the four patients without HBV-X integration who developed HCC did have cirrhosis. CONCLUSIONS: Our findings suggest that HBV-X integration detected at the mild fibrosis stage might not indicate a high risk for HCC. HBV-X integration may be associated with HCC development in the absence of cirrhosis. However, we did not find evidence that HBV-X integration directly plays a role in hepatocarcinogenesis in CH-C patients. Further studies will be needed to clarify this point. SN - 0168-8278 UR - https://www.unboundmedicine.com/medline/citation/18023912/Impact_of_hepatitis_B_virus__HBV__X_gene_integration_in_liver_tissue_on_hepatocellular_carcinoma_development_in_serologically_HBV_negative_chronic_hepatitis_C_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8278(07)00562-4 DB - PRIME DP - Unbound Medicine ER -