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Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulation.
Prog Neurobiol. 2007 Dec; 83(5):310-31.PN

Abstract

This review summarizes recent developments that have contributed to understand how adenosine receptors, particularly A2A receptors, modulate brain injury in various animal models of neurological disorders, including Parkinson's disease (PD), stroke, Huntington's disease (HD), multiple sclerosis, Alzheimer's disease (AD) and HIV-associated dementia. It is clear that extracellular adenosine acting at adenosine receptors influences the functional outcome in a broad spectrum of brain injuries, indicating that A2A Rs may modulate some general cellular processes to affect neuronal cells death. Pharmacological, neurochemical and molecular/genetic approaches to the complex actions of A2A receptors in different cellular elements suggest that A2A receptor activation can be detrimental or protective after brain insults, depending on the nature of brain injury and associated pathological conditions. An interesting concept that emerges from these studies is A2A R's ability to fine tune neuronal and glial functions to produce neuroprotective effects. While the data presented here clearly highlight the complexity of using adenosinergic agents therapeutically in PD and other neurodegenerative disorders and point out many areas for further inquiry, they also confirm that adenosine receptor ligands, particularly A2A receptor ligands, have many promising characteristics that encourage the pursuit of their therapeutic potential.

Authors+Show Affiliations

Chen JF
Department of Neurology, Boston University School of Medicine, 715 Albany Street, C329, Boston, MA 02118, USA. chenjf@bu.edu
Sonsalla PK
No affiliation info available
Pedata F
No affiliation info available
Melani A
No affiliation info available
Domenici MR
No affiliation info available
Popoli P
No affiliation info available
Geiger J
No affiliation info available
Lopes LV
No affiliation info available
de Mendonça A
No affiliation info available

MeSH

AdenosineAnimalsBrainBrain DiseasesBrain Injury, ChronicCell SurvivalCytoprotectionHumansNerve DegenerationNeuroprotective AgentsReceptor, Adenosine A2A

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18023959

Citation

Chen, Jiang-Fan, et al. "Adenosine A2A Receptors and Brain Injury: Broad Spectrum of Neuroprotection, Multifaceted Actions and "fine Tuning" Modulation." Progress in Neurobiology, vol. 83, no. 5, 2007, pp. 310-31.
Chen JF, Sonsalla PK, Pedata F, et al. Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulation. Prog Neurobiol. 2007;83(5):310-31.
Chen, J. F., Sonsalla, P. K., Pedata, F., Melani, A., Domenici, M. R., Popoli, P., Geiger, J., Lopes, L. V., & de Mendonça, A. (2007). Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulation. Progress in Neurobiology, 83(5), 310-31.
Chen JF, et al. Adenosine A2A Receptors and Brain Injury: Broad Spectrum of Neuroprotection, Multifaceted Actions and "fine Tuning" Modulation. Prog Neurobiol. 2007;83(5):310-31. PubMed PMID: 18023959.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulation. AU - Chen,Jiang-Fan, AU - Sonsalla,Patricia K, AU - Pedata,Felicita, AU - Melani,Alessia, AU - Domenici,Maria Rosaria, AU - Popoli,Patrizia, AU - Geiger,Jonathan, AU - Lopes,Luísa V, AU - de Mendonça,Alexandre, Y1 - 2007/09/29/ PY - 2007/03/12/received PY - 2007/08/10/revised PY - 2007/09/21/accepted PY - 2007/11/21/pubmed PY - 2008/2/5/medline PY - 2007/11/21/entrez SP - 310 EP - 31 JF - Progress in neurobiology JO - Prog Neurobiol VL - 83 IS - 5 N2 - This review summarizes recent developments that have contributed to understand how adenosine receptors, particularly A2A receptors, modulate brain injury in various animal models of neurological disorders, including Parkinson's disease (PD), stroke, Huntington's disease (HD), multiple sclerosis, Alzheimer's disease (AD) and HIV-associated dementia. It is clear that extracellular adenosine acting at adenosine receptors influences the functional outcome in a broad spectrum of brain injuries, indicating that A2A Rs may modulate some general cellular processes to affect neuronal cells death. Pharmacological, neurochemical and molecular/genetic approaches to the complex actions of A2A receptors in different cellular elements suggest that A2A receptor activation can be detrimental or protective after brain insults, depending on the nature of brain injury and associated pathological conditions. An interesting concept that emerges from these studies is A2A R's ability to fine tune neuronal and glial functions to produce neuroprotective effects. While the data presented here clearly highlight the complexity of using adenosinergic agents therapeutically in PD and other neurodegenerative disorders and point out many areas for further inquiry, they also confirm that adenosine receptor ligands, particularly A2A receptor ligands, have many promising characteristics that encourage the pursuit of their therapeutic potential. SN - 0301-0082 UR - https://www.unboundmedicine.com/medline/citation/18023959/Adenosine_A2A_receptors_and_brain_injury:_broad_spectrum_of_neuroprotection_multifaceted_actions_and_"fine_tuning"_modulation_ DB - PRIME DP - Unbound Medicine ER -