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Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin.

Abstract

The health beneficial effects of a diet rich in fruits and vegetables are, at least in part, attributed to polyphenols that are present in many herbal edibles. Although many in vitro studies revealed a striking variety of biochemical and pharmacological properties data about the beneficial effects of polyphenols in whole organisms, especially with respect to ageing, are quite limited. We used the well established model organism Caenorhabditis elegans to elucidate the protective effects of quercetin, the main representative of the flavonol class of polyphenols, in vivo. Quercetin is taken up by the worms, enhanced the resistance to oxidative stress and prolonged the mean lifespan of C. elegans by 15%. Quercetin was shown to be a strong radical scavenger possibly explaining the observed down-regulation of mitochondrial manganese superoxide dismutase by a reduced need for this antioxidant enzyme for maintenance of cellular redox homeostasis. Quercetin treatment also led to a translocation of the C. elegans FoxO transcription factor DAF-16 into the nucleus, a state often correlated with stress response and longevity. According to our results we suggest that the protective and life prolonging action of quercetin is not only due to its strong antioxidant capacity but may also be mediated by modulation of signalling pathways.

Authors+Show Affiliations

Institute of Toxicology, Heinrich-Heine University, Düsseldorf, Germany. kampkoet@uni-duesseldorf.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18024103

Citation

Kampkötter, Andreas, et al. "Increase of Stress Resistance and Lifespan of Caenorhabditis Elegans By Quercetin." Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology, vol. 149, no. 2, 2008, pp. 314-23.
Kampkötter A, Timpel C, Zurawski RF, et al. Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin. Comp Biochem Physiol B, Biochem Mol Biol. 2008;149(2):314-23.
Kampkötter, A., Timpel, C., Zurawski, R. F., Ruhl, S., Chovolou, Y., Proksch, P., & Wätjen, W. (2008). Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin. Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology, 149(2), pp. 314-23.
Kampkötter A, et al. Increase of Stress Resistance and Lifespan of Caenorhabditis Elegans By Quercetin. Comp Biochem Physiol B, Biochem Mol Biol. 2008;149(2):314-23. PubMed PMID: 18024103.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin. AU - Kampkötter,Andreas, AU - Timpel,Claudia, AU - Zurawski,Ruben Felix, AU - Ruhl,Sven, AU - Chovolou,Yvonni, AU - Proksch,Peter, AU - Wätjen,Wim, Y1 - 2007/10/16/ PY - 2007/08/03/received PY - 2007/10/08/revised PY - 2007/10/08/accepted PY - 2007/11/21/pubmed PY - 2008/4/4/medline PY - 2007/11/21/entrez SP - 314 EP - 23 JF - Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology JO - Comp. Biochem. Physiol. B, Biochem. Mol. Biol. VL - 149 IS - 2 N2 - The health beneficial effects of a diet rich in fruits and vegetables are, at least in part, attributed to polyphenols that are present in many herbal edibles. Although many in vitro studies revealed a striking variety of biochemical and pharmacological properties data about the beneficial effects of polyphenols in whole organisms, especially with respect to ageing, are quite limited. We used the well established model organism Caenorhabditis elegans to elucidate the protective effects of quercetin, the main representative of the flavonol class of polyphenols, in vivo. Quercetin is taken up by the worms, enhanced the resistance to oxidative stress and prolonged the mean lifespan of C. elegans by 15%. Quercetin was shown to be a strong radical scavenger possibly explaining the observed down-regulation of mitochondrial manganese superoxide dismutase by a reduced need for this antioxidant enzyme for maintenance of cellular redox homeostasis. Quercetin treatment also led to a translocation of the C. elegans FoxO transcription factor DAF-16 into the nucleus, a state often correlated with stress response and longevity. According to our results we suggest that the protective and life prolonging action of quercetin is not only due to its strong antioxidant capacity but may also be mediated by modulation of signalling pathways. SN - 1096-4959 UR - https://www.unboundmedicine.com/medline/citation/18024103/Increase_of_stress_resistance_and_lifespan_of_Caenorhabditis_elegans_by_quercetin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1096-4959(07)00386-7 DB - PRIME DP - Unbound Medicine ER -