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Thyrotoxicosis associated Wernicke's encephalopathy.
J Gen Intern Med. 2008 Jan; 23(1):106-9.JG

Abstract

BACKGROUND

Wernicke's encephalopathy is a rare disorder resulting from nutrition deficiency in thiamine (vitamin B1). It is most often associated with chronic alcohol abuse. It can accompany other disorders such as hyperemesis gravidarum and hyperthyroidism.

CASE

We present a case of severe Wernicke's encephalopathy that developed in a male non-alcoholic inpatient that was precipitated by poor nutritional intake and development of thyrotoxicosis. It is likely that the hypermetabolic state from thyrotoxicosis contributed to the development of Wernicke's encephalopathy, which was extremely debilitating.

CONCLUSION

Wernicke's encephalopathy is a severe, life-threatening illness that can be a consequence of hyperthyroidism in addition to alcohol abuse and can be easily prevented with appropriate supplementation of thiamine.

Links

PMC Free PDF

Authors+Show Affiliations

Bonucchi J
Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA. james-bonucchi@uiowa.edu
Hassan I
No affiliation info available
Policeni B
No affiliation info available
Kaboli P
No affiliation info available

MeSH

AdultHumansMagnetic Resonance ImagingMalePrisonersStarvationThiamineThiamine DeficiencyThyroid Function TestsThyrotoxicosisVitamin B ComplexWernicke Encephalopathy

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

18026802

Citation

Bonucchi, James, et al. "Thyrotoxicosis Associated Wernicke's Encephalopathy." Journal of General Internal Medicine, vol. 23, no. 1, 2008, pp. 106-9.
Bonucchi J, Hassan I, Policeni B, et al. Thyrotoxicosis associated Wernicke's encephalopathy. J Gen Intern Med. 2008;23(1):106-9.
Bonucchi, J., Hassan, I., Policeni, B., & Kaboli, P. (2008). Thyrotoxicosis associated Wernicke's encephalopathy. Journal of General Internal Medicine, 23(1), 106-9.
Bonucchi J, et al. Thyrotoxicosis Associated Wernicke's Encephalopathy. J Gen Intern Med. 2008;23(1):106-9. PubMed PMID: 18026802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thyrotoxicosis associated Wernicke's encephalopathy. AU - Bonucchi,James, AU - Hassan,Ihab, AU - Policeni,Bruno, AU - Kaboli,Peter, Y1 - 2007/11/17/ PY - 2007/05/08/received PY - 2007/10/12/accepted PY - 2007/10/05/revised PY - 2007/11/21/pubmed PY - 2008/1/29/medline PY - 2007/11/21/entrez SP - 106 EP - 9 JF - Journal of general internal medicine JO - J Gen Intern Med VL - 23 IS - 1 N2 - BACKGROUND: Wernicke's encephalopathy is a rare disorder resulting from nutrition deficiency in thiamine (vitamin B1). It is most often associated with chronic alcohol abuse. It can accompany other disorders such as hyperemesis gravidarum and hyperthyroidism. CASE: We present a case of severe Wernicke's encephalopathy that developed in a male non-alcoholic inpatient that was precipitated by poor nutritional intake and development of thyrotoxicosis. It is likely that the hypermetabolic state from thyrotoxicosis contributed to the development of Wernicke's encephalopathy, which was extremely debilitating. CONCLUSION: Wernicke's encephalopathy is a severe, life-threatening illness that can be a consequence of hyperthyroidism in addition to alcohol abuse and can be easily prevented with appropriate supplementation of thiamine. SN - 1525-1497 UR - https://www.unboundmedicine.com/medline/citation/18026802/Thyrotoxicosis_associated_Wernicke's_encephalopathy_ DB - PRIME DP - Unbound Medicine ER -