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Acetyl-L-carnitine prevents selenite-induced cataractogenesis in an experimental animal model.
Curr Eye Res. 2007 Nov; 32(11):961-71.CE

Abstract

PURPOSE

To investigate whether acetyl-L-carnitine (ALCAR) retards selenite-induced cataractogenesis in vivo.

METHODS

On postpartum day 10, group I pups received intraperitoneal saline and group II and group III pups received subcutaneous sodium selenite; Group III pups also received intraperitoneal ALCAR once daily on postpartum days 9-14. Both eyes of each pup were examined up to postpartum day 30. After sacrifice, extricated pup lenses were analyzed for antioxidant and redox system components.

RESULTS

There was dense lenticular opacification in all group II pups, minimal opacification in 33% of group III pups, and no opacification in 67% of group III and in all group I pups. Group II lenses exhibited significantly lower values of antioxidant and redox system components and higher malondialdehyde concentrations than group I or group III lenses.

CONCLUSION

ALCAR prevents selenite-induced cataractogenesis in Wistar rat pups, possibly by inhibiting depletion of antioxidant enzyme and redox system components and inhibiting lipid peroxidation.

Authors+Show Affiliations

Department of Animal Science, School of Life Sciences, Bharathidasan University, Tamil Nadu, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18027172

Citation

Elanchezhian, R, et al. "Acetyl-L-carnitine Prevents Selenite-induced Cataractogenesis in an Experimental Animal Model." Current Eye Research, vol. 32, no. 11, 2007, pp. 961-71.
Elanchezhian R, Ramesh E, Sakthivel M, et al. Acetyl-L-carnitine prevents selenite-induced cataractogenesis in an experimental animal model. Curr Eye Res. 2007;32(11):961-71.
Elanchezhian, R., Ramesh, E., Sakthivel, M., Isai, M., Geraldine, P., Rajamohan, M., Jesudasan, C. N., & Thomas, P. A. (2007). Acetyl-L-carnitine prevents selenite-induced cataractogenesis in an experimental animal model. Current Eye Research, 32(11), 961-71.
Elanchezhian R, et al. Acetyl-L-carnitine Prevents Selenite-induced Cataractogenesis in an Experimental Animal Model. Curr Eye Res. 2007;32(11):961-71. PubMed PMID: 18027172.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acetyl-L-carnitine prevents selenite-induced cataractogenesis in an experimental animal model. AU - Elanchezhian,R, AU - Ramesh,E, AU - Sakthivel,M, AU - Isai,M, AU - Geraldine,P, AU - Rajamohan,M, AU - Jesudasan,C Nelson, AU - Thomas,P A, PY - 2007/11/21/pubmed PY - 2008/1/16/medline PY - 2007/11/21/entrez SP - 961 EP - 71 JF - Current eye research JO - Curr Eye Res VL - 32 IS - 11 N2 - PURPOSE: To investigate whether acetyl-L-carnitine (ALCAR) retards selenite-induced cataractogenesis in vivo. METHODS: On postpartum day 10, group I pups received intraperitoneal saline and group II and group III pups received subcutaneous sodium selenite; Group III pups also received intraperitoneal ALCAR once daily on postpartum days 9-14. Both eyes of each pup were examined up to postpartum day 30. After sacrifice, extricated pup lenses were analyzed for antioxidant and redox system components. RESULTS: There was dense lenticular opacification in all group II pups, minimal opacification in 33% of group III pups, and no opacification in 67% of group III and in all group I pups. Group II lenses exhibited significantly lower values of antioxidant and redox system components and higher malondialdehyde concentrations than group I or group III lenses. CONCLUSION: ALCAR prevents selenite-induced cataractogenesis in Wistar rat pups, possibly by inhibiting depletion of antioxidant enzyme and redox system components and inhibiting lipid peroxidation. SN - 0271-3683 UR - https://www.unboundmedicine.com/medline/citation/18027172/Acetyl_L_carnitine_prevents_selenite_induced_cataractogenesis_in_an_experimental_animal_model_ L2 - https://www.tandfonline.com/doi/full/10.1080/02713680701673470 DB - PRIME DP - Unbound Medicine ER -