TY - JOUR T1 - Modulation of a pulsatile release drug delivery system using different swellable/rupturable materials. A1 - El-Maradny,Hoda A, PY - 2007/11/21/pubmed PY - 2008/2/21/medline PY - 2007/11/21/entrez SP - 539 EP - 46 JF - Drug delivery JO - Drug Deliv VL - 14 IS - 8 N2 - Diclofenac sodium tablets consisting of core coated with two layers of swelling and rupturable coatings were prepared and evaluated as a pulsatile drug delivery system. Cores containing the drug were prepared by direct compression using microcrystalline cellulose and Ludipress as hydrophilic excipients with the ratio of 1:1. Cores were then coated sequentially with an inner swelling layer of different swellable materials; either Explotab, Croscarmellose sodium, or Starch RX 1500, and an outer rupturable layer of different levels of ethylcellulose. The effect of the nature of the swelling layer and the level of the rupturable coating on the lag time and the water uptake were investigated. Drug release rate studies were performed using USP paddle method. Results showed the dependence of the lag time and water uptake prior to tablet rupture on the nature of the swelling layer and the coating levels. Explotab showed a significant decrease in the lag time, followed by Croscarmellose sodium and finally by Starch RX 1500. Increasing the level of ethylcellulose coating retarded the diffusion of the release medium to the swelling layer and the rupture of the coat, thus prolonging the lag time. SN - 1071-7544 UR - https://www.unboundmedicine.com/medline/citation/18027184/Modulation_of_a_pulsatile_release_drug_delivery_system_using_different_swellable/rupturable_materials_ DB - PRIME DP - Unbound Medicine ER -