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Overweight and obesity and incidence of leukemia: a meta-analysis of cohort studies.
Int J Cancer 2008; 122(6):1418-21IJ

Abstract

We conducted a meta-analysis to summarize the available evidence from cohort studies on the association between excess body weight and incidence of leukemia. Studies were identified by searching the MEDLINE and EMBASE databases (1966-July 2007) and by examining the references of retrieved articles. A random-effects model was used to combine the results from individual studies. We identified 9 cohort studies with data on body mass index (BMI) or obesity in relation to incidence of leukemia. Compared with nonoverweight individuals (BMI < 25 kg/m(2)), the summary relative risks (RRs) of leukemia were 1.14 [95% confidence interval (CI), 1.03-1.25] for overweight individuals (BMI 25-30 kg/m(2)) and 1.39 (95% CI, 1.25-1.54) for obese (BMI >or= 30 kg/m(2)) individuals. On a continuous scale, a 5 kg/m(2) increase in BMI was associated with a 13% increased risk of leukemia (RR, 1.13; 95% CI, 1.07-1.19). In a meta-analysis of 4 studies reporting results on subtypes of leukemia, the summary RRs associated with obesity were 1.25 (95% CI, 1.11-1.41) for chronic lymphocytic leukemia, 1.65 (95% CI, 1.16-2.35) for acute lymphocytic leukemia, 1.52 (95% CI, 1.19-1.95) for acute myeloid leukemia and 1.26 (95% CI, 1.09-1.46) for chronic myeloid leukemia. This meta-analysis indicates that excess body weight is associated with an increased risk of developing leukemia.

Authors+Show Affiliations

Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. susanna.larsson@ki.seNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18027857

Citation

Larsson, Susanna C., and Alicja Wolk. "Overweight and Obesity and Incidence of Leukemia: a Meta-analysis of Cohort Studies." International Journal of Cancer, vol. 122, no. 6, 2008, pp. 1418-21.
Larsson SC, Wolk A. Overweight and obesity and incidence of leukemia: a meta-analysis of cohort studies. Int J Cancer. 2008;122(6):1418-21.
Larsson, S. C., & Wolk, A. (2008). Overweight and obesity and incidence of leukemia: a meta-analysis of cohort studies. International Journal of Cancer, 122(6), pp. 1418-21.
Larsson SC, Wolk A. Overweight and Obesity and Incidence of Leukemia: a Meta-analysis of Cohort Studies. Int J Cancer. 2008 Mar 15;122(6):1418-21. PubMed PMID: 18027857.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Overweight and obesity and incidence of leukemia: a meta-analysis of cohort studies. AU - Larsson,Susanna C, AU - Wolk,Alicja, PY - 2007/11/22/pubmed PY - 2008/4/2/medline PY - 2007/11/22/entrez SP - 1418 EP - 21 JF - International journal of cancer JO - Int. J. Cancer VL - 122 IS - 6 N2 - We conducted a meta-analysis to summarize the available evidence from cohort studies on the association between excess body weight and incidence of leukemia. Studies were identified by searching the MEDLINE and EMBASE databases (1966-July 2007) and by examining the references of retrieved articles. A random-effects model was used to combine the results from individual studies. We identified 9 cohort studies with data on body mass index (BMI) or obesity in relation to incidence of leukemia. Compared with nonoverweight individuals (BMI < 25 kg/m(2)), the summary relative risks (RRs) of leukemia were 1.14 [95% confidence interval (CI), 1.03-1.25] for overweight individuals (BMI 25-30 kg/m(2)) and 1.39 (95% CI, 1.25-1.54) for obese (BMI >or= 30 kg/m(2)) individuals. On a continuous scale, a 5 kg/m(2) increase in BMI was associated with a 13% increased risk of leukemia (RR, 1.13; 95% CI, 1.07-1.19). In a meta-analysis of 4 studies reporting results on subtypes of leukemia, the summary RRs associated with obesity were 1.25 (95% CI, 1.11-1.41) for chronic lymphocytic leukemia, 1.65 (95% CI, 1.16-2.35) for acute lymphocytic leukemia, 1.52 (95% CI, 1.19-1.95) for acute myeloid leukemia and 1.26 (95% CI, 1.09-1.46) for chronic myeloid leukemia. This meta-analysis indicates that excess body weight is associated with an increased risk of developing leukemia. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/18027857/Overweight_and_obesity_and_incidence_of_leukemia:_a_meta_analysis_of_cohort_studies_ L2 - https://doi.org/10.1002/ijc.23176 DB - PRIME DP - Unbound Medicine ER -