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Mild cognitive impairment: epidemiology and dementia risk in an elderly Italian population.

Abstract

OBJECTIVES

To investigate prevalence and incidence of mild cognitive impairment (MCI) and its risk of progression to dementia in an elderly Italian population.

DESIGN

Longitudinal.

SETTING

Population-based cohort aged 65 and older resident in an Italian municipality.

PARTICIPANTS

A total of 1,016 subjects underwent baseline evaluation in 1999/2000. In 2003/04, information about cognitive outcome was collected for 745 participants who were free of dementia at baseline.

MEASUREMENTS

MCI (classified as with or without impairment of the memory domain), dementia, Alzheimer's dementia (AD), and vascular dementia (VaD) diagnosed according to current international criteria.

RESULTS

Overall prevalence of MCI was 7.7% (95% confidence interval (CI)=6.1-9.7 %) and was greater with older age and poor education. During 4 years of follow-up, 155 incident MCI cases were diagnosed, with an incidence rate of 76.8 (95% CI=66.8-88.4) per 1,000 person-years. Approximately half of prevalent and incident MCI cases had memory impairment. Compared with normal cognition, multivariable-adjusted risk for progression from MCI with memory impairment to dementia was 4.78 (95% CI=2.78-8.07) for any dementia, 5.92 (95% CI=3.20-10.91) for AD, and 1.61 (95% CI=0.37-7.00) for VaD. No association with dementia risk was found for MCI without memory impairment. Approximately one-third of MCI cases with memory impairment did not progress to dementia.

CONCLUSION

MCI occurs often in this elderly Italian cohort and is associated with greater risk of AD, but only when the impairment involves the memory domain. However, a substantial proportion of MCI cases with memory impairment do not progress to dementia.

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  • Authors+Show Affiliations

    ,

    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S. Orsola-Malpighi, Bologna, Italy. ravaglia@med.unibo.it

    , , , , , , ,

    Source

    MeSH

    Aged
    Cognition Disorders
    Confidence Intervals
    Dementia
    Disease Progression
    Female
    Humans
    Incidence
    Italy
    Male
    Prevalence
    Retrospective Studies
    Risk Factors
    Urban Population

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18028343

    Citation

    Ravaglia, Giovanni, et al. "Mild Cognitive Impairment: Epidemiology and Dementia Risk in an Elderly Italian Population." Journal of the American Geriatrics Society, vol. 56, no. 1, 2008, pp. 51-8.
    Ravaglia G, Forti P, Montesi F, et al. Mild cognitive impairment: epidemiology and dementia risk in an elderly Italian population. J Am Geriatr Soc. 2008;56(1):51-8.
    Ravaglia, G., Forti, P., Montesi, F., Lucicesare, A., Pisacane, N., Rietti, E., ... Mecocci, P. (2008). Mild cognitive impairment: epidemiology and dementia risk in an elderly Italian population. Journal of the American Geriatrics Society, 56(1), pp. 51-8.
    Ravaglia G, et al. Mild Cognitive Impairment: Epidemiology and Dementia Risk in an Elderly Italian Population. J Am Geriatr Soc. 2008;56(1):51-8. PubMed PMID: 18028343.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Mild cognitive impairment: epidemiology and dementia risk in an elderly Italian population. AU - Ravaglia,Giovanni, AU - Forti,Paola, AU - Montesi,Fausta, AU - Lucicesare,Anna, AU - Pisacane,Nicoletta, AU - Rietti,Elisa, AU - Dalmonte,Edoardo, AU - Bianchin,Marisa, AU - Mecocci,Patrizia, Y1 - 2007/11/20/ PY - 2007/11/22/pubmed PY - 2008/1/25/medline PY - 2007/11/22/entrez SP - 51 EP - 8 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 56 IS - 1 N2 - OBJECTIVES: To investigate prevalence and incidence of mild cognitive impairment (MCI) and its risk of progression to dementia in an elderly Italian population. DESIGN: Longitudinal. SETTING: Population-based cohort aged 65 and older resident in an Italian municipality. PARTICIPANTS: A total of 1,016 subjects underwent baseline evaluation in 1999/2000. In 2003/04, information about cognitive outcome was collected for 745 participants who were free of dementia at baseline. MEASUREMENTS: MCI (classified as with or without impairment of the memory domain), dementia, Alzheimer's dementia (AD), and vascular dementia (VaD) diagnosed according to current international criteria. RESULTS: Overall prevalence of MCI was 7.7% (95% confidence interval (CI)=6.1-9.7 %) and was greater with older age and poor education. During 4 years of follow-up, 155 incident MCI cases were diagnosed, with an incidence rate of 76.8 (95% CI=66.8-88.4) per 1,000 person-years. Approximately half of prevalent and incident MCI cases had memory impairment. Compared with normal cognition, multivariable-adjusted risk for progression from MCI with memory impairment to dementia was 4.78 (95% CI=2.78-8.07) for any dementia, 5.92 (95% CI=3.20-10.91) for AD, and 1.61 (95% CI=0.37-7.00) for VaD. No association with dementia risk was found for MCI without memory impairment. Approximately one-third of MCI cases with memory impairment did not progress to dementia. CONCLUSION: MCI occurs often in this elderly Italian cohort and is associated with greater risk of AD, but only when the impairment involves the memory domain. However, a substantial proportion of MCI cases with memory impairment do not progress to dementia. SN - 1532-5415 UR - https://www.unboundmedicine.com/medline/citation/18028343/Mild_cognitive_impairment:_epidemiology_and_dementia_risk_in_an_elderly_Italian_population_ L2 - https://doi.org/10.1111/j.1532-5415.2007.01503.x DB - PRIME DP - Unbound Medicine ER -