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The association between the genetic polymorphism of HLA-DQA1, DQB1, and DRB1 and serum alanine aminotransferase levels in chronic hepatitis C in the Chinese population.
J Gastroenterol Hepatol. 2008 Sep; 23(9):1394-402.JG

Abstract

BACKGROUND AND AIM

To investigate a possible association between HLA genes with serum alanine aminotransferase (ALT) levels and evaluate whether the HLA-DQA1, DQB1, and DRB1 genes could influence the development of liver damage in chronic hepatitis C.

METHODS

A total of 145 patients with chronic hepatitis C virus (HCV) infection (36 patients with persistently normal ALT values; 109 patients with elevated ALT levels) and 160 uninfected healthy controls were examined for HLA-DQA1, DQB1, and DRB1 molecules by using polymerase chain reaction-sequencing based typing (PCR-SBT).

RESULTS

Among the patients chronically infected with HCV, the frequencies of DQA1*0501, DQB1*0301, and DRB1*0401 alleles were significantly increased in the normal ALT group compared with those with abnormal ALT levels, whereas that of DQB1*0201 was significantly lower. As compared to uninfected healthy controls, DQA1*0501, DQB1*0301, and DRB1*0401 allele frequencies were also statistically higher in the normal ALT group, whereas that of DQB1*0201 was the inverse. The haplotype frequencies of DQA1*0301-DQB1*0301, DQA1*0501-DQB1*0301, and DRB1*1101-DQB1*0301 were found to be significantly higher in the normal ALT group. Multivariate logistic regression indicated that female sex, and the DQB1*0301 allele and DRB1*0401 allele were independently associated with normal ALT values, whereas DQB1*0201 allele was the inverse.

CONCLUSIONS

These results suggest that particular HLA alleles may have an influence on the serum ALT level of chronic HCV infection as a host genetic factor in the Chinese population. The DQA1*0501, DQB1*0301, and DRB1*0401 alleles, and the DQA1*0301-DQB1*0301, DQA1*0501-DQB1*0301, and DRB1*1101-DQB1*0301 haplotypes seem to be associated with low hepatitis activity; whereas DQB1*0201 allele is closely correlated with the progression of liver injury in chronic HCV infection.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, School of Public Health, Jiangsu Province Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18028350

Citation

Yu, Rong-Bin, et al. "The Association Between the Genetic Polymorphism of HLA-DQA1, DQB1, and DRB1 and Serum Alanine Aminotransferase Levels in Chronic Hepatitis C in the Chinese Population." Journal of Gastroenterology and Hepatology, vol. 23, no. 9, 2008, pp. 1394-402.
Yu RB, Hong X, Ding WL, et al. The association between the genetic polymorphism of HLA-DQA1, DQB1, and DRB1 and serum alanine aminotransferase levels in chronic hepatitis C in the Chinese population. J Gastroenterol Hepatol. 2008;23(9):1394-402.
Yu, R. B., Hong, X., Ding, W. L., Tan, Y. F., Zhang, Y. X., Sun, N. X., Wu, G. L., Zhan, S. W., & Ge, D. F. (2008). The association between the genetic polymorphism of HLA-DQA1, DQB1, and DRB1 and serum alanine aminotransferase levels in chronic hepatitis C in the Chinese population. Journal of Gastroenterology and Hepatology, 23(9), 1394-402.
Yu RB, et al. The Association Between the Genetic Polymorphism of HLA-DQA1, DQB1, and DRB1 and Serum Alanine Aminotransferase Levels in Chronic Hepatitis C in the Chinese Population. J Gastroenterol Hepatol. 2008;23(9):1394-402. PubMed PMID: 18028350.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between the genetic polymorphism of HLA-DQA1, DQB1, and DRB1 and serum alanine aminotransferase levels in chronic hepatitis C in the Chinese population. AU - Yu,Rong-Bin, AU - Hong,Xin, AU - Ding,Wei-Liang, AU - Tan,Yong-Fei, AU - Zhang,Yong-Xiang, AU - Sun,Nan-Xiong, AU - Wu,Guan-Ling, AU - Zhan,Sheng-Wei, AU - Ge,Da-Fang, Y1 - 2007/11/19/ PY - 2007/11/22/pubmed PY - 2009/1/24/medline PY - 2007/11/22/entrez SP - 1394 EP - 402 JF - Journal of gastroenterology and hepatology JO - J Gastroenterol Hepatol VL - 23 IS - 9 N2 - BACKGROUND AND AIM: To investigate a possible association between HLA genes with serum alanine aminotransferase (ALT) levels and evaluate whether the HLA-DQA1, DQB1, and DRB1 genes could influence the development of liver damage in chronic hepatitis C. METHODS: A total of 145 patients with chronic hepatitis C virus (HCV) infection (36 patients with persistently normal ALT values; 109 patients with elevated ALT levels) and 160 uninfected healthy controls were examined for HLA-DQA1, DQB1, and DRB1 molecules by using polymerase chain reaction-sequencing based typing (PCR-SBT). RESULTS: Among the patients chronically infected with HCV, the frequencies of DQA1*0501, DQB1*0301, and DRB1*0401 alleles were significantly increased in the normal ALT group compared with those with abnormal ALT levels, whereas that of DQB1*0201 was significantly lower. As compared to uninfected healthy controls, DQA1*0501, DQB1*0301, and DRB1*0401 allele frequencies were also statistically higher in the normal ALT group, whereas that of DQB1*0201 was the inverse. The haplotype frequencies of DQA1*0301-DQB1*0301, DQA1*0501-DQB1*0301, and DRB1*1101-DQB1*0301 were found to be significantly higher in the normal ALT group. Multivariate logistic regression indicated that female sex, and the DQB1*0301 allele and DRB1*0401 allele were independently associated with normal ALT values, whereas DQB1*0201 allele was the inverse. CONCLUSIONS: These results suggest that particular HLA alleles may have an influence on the serum ALT level of chronic HCV infection as a host genetic factor in the Chinese population. The DQA1*0501, DQB1*0301, and DRB1*0401 alleles, and the DQA1*0301-DQB1*0301, DQA1*0501-DQB1*0301, and DRB1*1101-DQB1*0301 haplotypes seem to be associated with low hepatitis activity; whereas DQB1*0201 allele is closely correlated with the progression of liver injury in chronic HCV infection. SN - 1440-1746 UR - https://www.unboundmedicine.com/medline/citation/18028350/The_association_between_the_genetic_polymorphism_of_HLA_DQA1_DQB1_and_DRB1_and_serum_alanine_aminotransferase_levels_in_chronic_hepatitis_C_in_the_Chinese_population_ L2 - https://doi.org/10.1111/j.1440-1746.2007.05215.x DB - PRIME DP - Unbound Medicine ER -