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Effect of calcium and vitamin D supplementation on bone mineral density in children with inflammatory bowel disease.
J Pediatr Gastroenterol Nutr 2007; 45(5):538-45JP

Abstract

OBJECTIVES

The purpose of this study was to evaluate the effect of calcium and vitamin D2 supplementation on bone mineral density (BMD) in children with inflammatory bowel disease (IBD).

PATIENTS AND METHODS

This was an open-label, prospective study conducted over a 12-month period. Seventy-two patients were divided into 2 groups based on lumbar spine areal BMD (L2-4 aBMD). Patients with an L2-4 aBMD z score of -1 or higher were assigned to the control group (n = 33; mean age, 11.0 +/- 3.5 years; 20 boys). Patients with an L2-4 aBMD of less than -1 (n = 39; mean age 11.8 +/- 2.5 years; 25 boys) were allocated to the intervention group and received 1000 mg of supplemental elemental calcium daily for 12 months (n = 19) or supplemental calcium for 12 months and 50,000 IU of vitamin D2 monthly for 6 months (n = 20).

RESULTS

The 2 groups differed in L2-4 aBMD z scores (intervention, -1.9 +/- 0.6; control, -0.2 +/- 0.6; P < 0.001) and volumetric L2-4 BMD (vBMD; intervention, 0.29 +/- 0.04; control, 0.33 +/- 0.06; P < 0.001). After 1 year of therapy, the control and intervention groups had similar changes in height z scores, L2-4 aBMD, L2-4 vBMD (z score change, L2-4 aBMD: control 0.2 +/- 0.6 [n = 21], intervention 0.4 +/- 0.6; P = 0.4 [n = 26]; z score change, L2-4 vBMD: control 0.1 +/- 0.4, intervention 0.2 +/- 0.6; P = 0.74). The changes in these parameters were similar between patients who had received calcium only or calcium plus vitamin D.

CONCLUSIONS

These results suggest that, in children with IBD, supplementation of calcium and vitamin D does not accelerate accrual in L2-4 BMD.

Authors+Show Affiliations

Department of Pediatrics, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18030230

Citation

Benchimol, Eric I., et al. "Effect of Calcium and Vitamin D Supplementation On Bone Mineral Density in Children With Inflammatory Bowel Disease." Journal of Pediatric Gastroenterology and Nutrition, vol. 45, no. 5, 2007, pp. 538-45.
Benchimol EI, Ward LM, Gallagher JC, et al. Effect of calcium and vitamin D supplementation on bone mineral density in children with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2007;45(5):538-45.
Benchimol, E. I., Ward, L. M., Gallagher, J. C., Rauch, F., Barrowman, N., Warren, J., ... Mack, D. R. (2007). Effect of calcium and vitamin D supplementation on bone mineral density in children with inflammatory bowel disease. Journal of Pediatric Gastroenterology and Nutrition, 45(5), pp. 538-45.
Benchimol EI, et al. Effect of Calcium and Vitamin D Supplementation On Bone Mineral Density in Children With Inflammatory Bowel Disease. J Pediatr Gastroenterol Nutr. 2007;45(5):538-45. PubMed PMID: 18030230.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of calcium and vitamin D supplementation on bone mineral density in children with inflammatory bowel disease. AU - Benchimol,Eric I, AU - Ward,Leanne M, AU - Gallagher,J C, AU - Rauch,Frank, AU - Barrowman,Nick, AU - Warren,Jaime, AU - Beedle,Susan, AU - Mack,David R, PY - 2007/11/22/pubmed PY - 2008/1/16/medline PY - 2007/11/22/entrez SP - 538 EP - 45 JF - Journal of pediatric gastroenterology and nutrition JO - J. Pediatr. Gastroenterol. Nutr. VL - 45 IS - 5 N2 - OBJECTIVES: The purpose of this study was to evaluate the effect of calcium and vitamin D2 supplementation on bone mineral density (BMD) in children with inflammatory bowel disease (IBD). PATIENTS AND METHODS: This was an open-label, prospective study conducted over a 12-month period. Seventy-two patients were divided into 2 groups based on lumbar spine areal BMD (L2-4 aBMD). Patients with an L2-4 aBMD z score of -1 or higher were assigned to the control group (n = 33; mean age, 11.0 +/- 3.5 years; 20 boys). Patients with an L2-4 aBMD of less than -1 (n = 39; mean age 11.8 +/- 2.5 years; 25 boys) were allocated to the intervention group and received 1000 mg of supplemental elemental calcium daily for 12 months (n = 19) or supplemental calcium for 12 months and 50,000 IU of vitamin D2 monthly for 6 months (n = 20). RESULTS: The 2 groups differed in L2-4 aBMD z scores (intervention, -1.9 +/- 0.6; control, -0.2 +/- 0.6; P < 0.001) and volumetric L2-4 BMD (vBMD; intervention, 0.29 +/- 0.04; control, 0.33 +/- 0.06; P < 0.001). After 1 year of therapy, the control and intervention groups had similar changes in height z scores, L2-4 aBMD, L2-4 vBMD (z score change, L2-4 aBMD: control 0.2 +/- 0.6 [n = 21], intervention 0.4 +/- 0.6; P = 0.4 [n = 26]; z score change, L2-4 vBMD: control 0.1 +/- 0.4, intervention 0.2 +/- 0.6; P = 0.74). The changes in these parameters were similar between patients who had received calcium only or calcium plus vitamin D. CONCLUSIONS: These results suggest that, in children with IBD, supplementation of calcium and vitamin D does not accelerate accrual in L2-4 BMD. SN - 1536-4801 UR - https://www.unboundmedicine.com/medline/citation/18030230/Effect_of_calcium_and_vitamin_D_supplementation_on_bone_mineral_density_in_children_with_inflammatory_bowel_disease_ L2 - http://Insights.ovid.com/pubmed?pmid=18030230 DB - PRIME DP - Unbound Medicine ER -