Antifungal amides from Piper scutifolium and Piper hoffmanseggianum.J Nat Prod. 2007 Dec; 70(12):2036-9.JN
Chromatographic fractionation of a dichloromethane extract from the leaves of Piper scutifolium yielded two new isobutyl amides, scutifoliamide A (1) and scutifoliamide B (2), together with the known compounds piperolactam C (3), piperovatine (4), piperlonguminine (5), corcovadine (6), isopiperlonguminine (7), and isocorcovadine (8). From the dichloromethane extract from the leaves of P. hoffmannseggianum two new isobutyl amides, hoffmannseggiamide A (9) and hoffmannseggiamide B (10), were obtained together with the known compounds isopiperlonguminine (7) and isocorcovadine (8), sitosterol, and stigmasterol. The structures of the new compounds were established on the basis of spectroscopic data analysis. The inhibitory activity of compounds 1-10 against the growth of the fungi Cladosporium sphaerospermum and C. cladosporioides was determined by bioautography.