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Antifungal amides from Piper scutifolium and Piper hoffmanseggianum.
J Nat Prod. 2007 Dec; 70(12):2036-9.JN

Abstract

Chromatographic fractionation of a dichloromethane extract from the leaves of Piper scutifolium yielded two new isobutyl amides, scutifoliamide A (1) and scutifoliamide B (2), together with the known compounds piperolactam C (3), piperovatine (4), piperlonguminine (5), corcovadine (6), isopiperlonguminine (7), and isocorcovadine (8). From the dichloromethane extract from the leaves of P. hoffmannseggianum two new isobutyl amides, hoffmannseggiamide A (9) and hoffmannseggiamide B (10), were obtained together with the known compounds isopiperlonguminine (7) and isocorcovadine (8), sitosterol, and stigmasterol. The structures of the new compounds were established on the basis of spectroscopic data analysis. The inhibitory activity of compounds 1-10 against the growth of the fungi Cladosporium sphaerospermum and C. cladosporioides was determined by bioautography.

Authors+Show Affiliations

Marques JV
Instituto de Química, Universidade de São Paulo, CP 26077, 05513-970, São Paulo, SP, Brazil.
Kitamura RO
No affiliation info available
Lago JH
No affiliation info available
Young MC
No affiliation info available
Guimarães EF
No affiliation info available
Kato MJ
No affiliation info available

MeSH

AmidesAntifungal AgentsBenzodioxolesBrazilCladosporiumMolecular StructurePiperPlant LeavesPlants, Medicinal

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18031016

Citation

Marques, Joaquim V., et al. "Antifungal Amides From Piper Scutifolium and Piper Hoffmanseggianum." Journal of Natural Products, vol. 70, no. 12, 2007, pp. 2036-9.
Marques JV, Kitamura RO, Lago JH, et al. Antifungal amides from Piper scutifolium and Piper hoffmanseggianum. J Nat Prod. 2007;70(12):2036-9.
Marques, J. V., Kitamura, R. O., Lago, J. H., Young, M. C., Guimarães, E. F., & Kato, M. J. (2007). Antifungal amides from Piper scutifolium and Piper hoffmanseggianum. Journal of Natural Products, 70(12), 2036-9.
Marques JV, et al. Antifungal Amides From Piper Scutifolium and Piper Hoffmanseggianum. J Nat Prod. 2007;70(12):2036-9. PubMed PMID: 18031016.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antifungal amides from Piper scutifolium and Piper hoffmanseggianum. AU - Marques,Joaquim V, AU - Kitamura,Rodrigo O Saga, AU - Lago,João Henrique G, AU - Young,Maria Claudia M, AU - Guimarães,Elsie F, AU - Kato,Massuo J, Y1 - 2007/11/22/ PY - 2007/11/23/pubmed PY - 2008/3/7/medline PY - 2007/11/23/entrez SP - 2036 EP - 9 JF - Journal of natural products JO - J Nat Prod VL - 70 IS - 12 N2 - Chromatographic fractionation of a dichloromethane extract from the leaves of Piper scutifolium yielded two new isobutyl amides, scutifoliamide A (1) and scutifoliamide B (2), together with the known compounds piperolactam C (3), piperovatine (4), piperlonguminine (5), corcovadine (6), isopiperlonguminine (7), and isocorcovadine (8). From the dichloromethane extract from the leaves of P. hoffmannseggianum two new isobutyl amides, hoffmannseggiamide A (9) and hoffmannseggiamide B (10), were obtained together with the known compounds isopiperlonguminine (7) and isocorcovadine (8), sitosterol, and stigmasterol. The structures of the new compounds were established on the basis of spectroscopic data analysis. The inhibitory activity of compounds 1-10 against the growth of the fungi Cladosporium sphaerospermum and C. cladosporioides was determined by bioautography. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/18031016/Antifungal_amides_from_Piper_scutifolium_and_Piper_hoffmanseggianum_ DB - PRIME DP - Unbound Medicine ER -