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Anti-inflammatory effect of pimecrolimus in the sodium lauryl sulphate test.
J Eur Acad Dermatol Venereol. 2008 Apr; 22(4):447-50.JE

Abstract

BACKGROUND

Pimecrolimus is a calcineurin inhibitor used for the topical treatment of inflammatory skin diseases. We have shown previously that pimecrolimus cream is not effective on intact skin in the ultraviolet erythema test.

OBJECTIVE

To test the anti-inflammatory effect of pimecrolimus cream after damage of the skin barrier by sodium lauryl sulphate (SLS) in a randomised, placebo-controlled, observer-blinded study.

METHODS

SLS (3% v/v) was applied under occlusion on the back of 36 healthy volunteers for 24 h. Subsequently, the test areas were treated for 24 h with pimecrolimus cream, 1% hydrocortisone in a hydrophilic ointment, and the vehicle alone over three consecutive days. One control area remained untreated. The erythema index and the transepidermal water loss (TEWL) served as readout parameters to assess the SLS-induced skin irritation.

RESULTS

Pimecrolimus cream and 1% hydrocortisone cream significantly reduced the SLS-induced erythema. The two test preparations did not have a significant effect on the TEWL.

CONCLUSION

After damage to the skin barrier by SLS, pimecrolimus seems to penetrate into the skin as shown by a reduction of the irritation-induced erythma. These data further support the notion that pimecrolimus is selectively effective in the treatment of skin disorders with an impaired function of the epidermal barrier.

Authors+Show Affiliations

Department of Dermatology, University Medical Center, Freiburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18031501

Citation

Engel, K, et al. "Anti-inflammatory Effect of Pimecrolimus in the Sodium Lauryl Sulphate Test." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 22, no. 4, 2008, pp. 447-50.
Engel K, Reuter J, Seiler C, et al. Anti-inflammatory effect of pimecrolimus in the sodium lauryl sulphate test. J Eur Acad Dermatol Venereol. 2008;22(4):447-50.
Engel, K., Reuter, J., Seiler, C., Schulte Mönting, J., Jakob, T., & Schempp, C. M. (2008). Anti-inflammatory effect of pimecrolimus in the sodium lauryl sulphate test. Journal of the European Academy of Dermatology and Venereology : JEADV, 22(4), 447-50.
Engel K, et al. Anti-inflammatory Effect of Pimecrolimus in the Sodium Lauryl Sulphate Test. J Eur Acad Dermatol Venereol. 2008;22(4):447-50. PubMed PMID: 18031501.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory effect of pimecrolimus in the sodium lauryl sulphate test. AU - Engel,K, AU - Reuter,J, AU - Seiler,C, AU - Schulte Mönting,J, AU - Jakob,T, AU - Schempp,C M, Y1 - 2007/11/19/ PY - 2007/11/23/pubmed PY - 2008/5/7/medline PY - 2007/11/23/entrez SP - 447 EP - 50 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 22 IS - 4 N2 - BACKGROUND: Pimecrolimus is a calcineurin inhibitor used for the topical treatment of inflammatory skin diseases. We have shown previously that pimecrolimus cream is not effective on intact skin in the ultraviolet erythema test. OBJECTIVE: To test the anti-inflammatory effect of pimecrolimus cream after damage of the skin barrier by sodium lauryl sulphate (SLS) in a randomised, placebo-controlled, observer-blinded study. METHODS: SLS (3% v/v) was applied under occlusion on the back of 36 healthy volunteers for 24 h. Subsequently, the test areas were treated for 24 h with pimecrolimus cream, 1% hydrocortisone in a hydrophilic ointment, and the vehicle alone over three consecutive days. One control area remained untreated. The erythema index and the transepidermal water loss (TEWL) served as readout parameters to assess the SLS-induced skin irritation. RESULTS: Pimecrolimus cream and 1% hydrocortisone cream significantly reduced the SLS-induced erythema. The two test preparations did not have a significant effect on the TEWL. CONCLUSION: After damage to the skin barrier by SLS, pimecrolimus seems to penetrate into the skin as shown by a reduction of the irritation-induced erythma. These data further support the notion that pimecrolimus is selectively effective in the treatment of skin disorders with an impaired function of the epidermal barrier. SN - 1468-3083 UR - https://www.unboundmedicine.com/medline/citation/18031501/Anti_inflammatory_effect_of_pimecrolimus_in_the_sodium_lauryl_sulphate_test_ L2 - https://doi.org/10.1111/j.1468-3083.2007.02477.x DB - PRIME DP - Unbound Medicine ER -