Tags

Type your tag names separated by a space and hit enter

Neuroprotection and functional recovery conferred by administration of kappa- and delta 1-opioid agonists in a rat model of global ischemia.
Physiol Behav. 2008 Feb 27; 93(3):502-11.PB

Abstract

Studies that have evaluated the beneficial effect of pre-ischemic treatment of kappa-opioid receptor agonists have used short-term reperfusion intervals. We examined the long-term impact of the pre-ischemic peripheral injection of U50,488H (trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzeneacetamide), a selective kappa-opioid receptor agonist, on neuronal damage and behavioral deficits following global ischemia in rats. Four groups of ischemic rats were pretreated with various doses of U50,488H (i.p. 0, 5, 15, 30 mg/kg) 15 min prior to vessel occlusion. Two groups of sham-operated animals that received either saline or U50,488H (30 mg/kg) acted as controls. The injection of 30 mg/kg U50,488H led to a 65% increase in CA1 neuron survival 35 days post-ischemia. CA1 neuronal protection translated into significant improvement of ischemia-induced spatial memory deficits assessed in the 8-arm radial maze. However, there was no difference in activity in the open field. We also found that the pre-ischemic intracerebroventricular injection of 5 mug of the delta1-opioid receptor agonist DPDPE ([d-Pen(2,5)]-enkephalin) produced a 59% increase in CA1 neuron survival 7 days post-ischemia. Similar to U50,488H, DPDPE had no significant impact on locomotor activity. These findings support a role for kappa- and delta-opioid receptors in attenuation of ischemia-induced hippocampal damage and cognitive impairments.

Authors+Show Affiliations

University of Ottawa, School of Psychology, Ottawa, ON, Canada K1N 9A9.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18031772

Citation

Charron, Charlaine, et al. "Neuroprotection and Functional Recovery Conferred By Administration of Kappa- and Delta 1-opioid Agonists in a Rat Model of Global Ischemia." Physiology & Behavior, vol. 93, no. 3, 2008, pp. 502-11.
Charron C, Messier C, Plamondon H. Neuroprotection and functional recovery conferred by administration of kappa- and delta 1-opioid agonists in a rat model of global ischemia. Physiol Behav. 2008;93(3):502-11.
Charron, C., Messier, C., & Plamondon, H. (2008). Neuroprotection and functional recovery conferred by administration of kappa- and delta 1-opioid agonists in a rat model of global ischemia. Physiology & Behavior, 93(3), 502-11.
Charron C, Messier C, Plamondon H. Neuroprotection and Functional Recovery Conferred By Administration of Kappa- and Delta 1-opioid Agonists in a Rat Model of Global Ischemia. Physiol Behav. 2008 Feb 27;93(3):502-11. PubMed PMID: 18031772.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotection and functional recovery conferred by administration of kappa- and delta 1-opioid agonists in a rat model of global ischemia. AU - Charron,Charlaine, AU - Messier,Claude, AU - Plamondon,Hélène, Y1 - 2007/11/26/ PY - 2007/06/15/received PY - 2007/10/10/revised PY - 2007/10/16/accepted PY - 2007/11/23/pubmed PY - 2008/6/13/medline PY - 2007/11/23/entrez SP - 502 EP - 11 JF - Physiology & behavior JO - Physiol Behav VL - 93 IS - 3 N2 - Studies that have evaluated the beneficial effect of pre-ischemic treatment of kappa-opioid receptor agonists have used short-term reperfusion intervals. We examined the long-term impact of the pre-ischemic peripheral injection of U50,488H (trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzeneacetamide), a selective kappa-opioid receptor agonist, on neuronal damage and behavioral deficits following global ischemia in rats. Four groups of ischemic rats were pretreated with various doses of U50,488H (i.p. 0, 5, 15, 30 mg/kg) 15 min prior to vessel occlusion. Two groups of sham-operated animals that received either saline or U50,488H (30 mg/kg) acted as controls. The injection of 30 mg/kg U50,488H led to a 65% increase in CA1 neuron survival 35 days post-ischemia. CA1 neuronal protection translated into significant improvement of ischemia-induced spatial memory deficits assessed in the 8-arm radial maze. However, there was no difference in activity in the open field. We also found that the pre-ischemic intracerebroventricular injection of 5 mug of the delta1-opioid receptor agonist DPDPE ([d-Pen(2,5)]-enkephalin) produced a 59% increase in CA1 neuron survival 7 days post-ischemia. Similar to U50,488H, DPDPE had no significant impact on locomotor activity. These findings support a role for kappa- and delta-opioid receptors in attenuation of ischemia-induced hippocampal damage and cognitive impairments. SN - 0031-9384 UR - https://www.unboundmedicine.com/medline/citation/18031772/Neuroprotection_and_functional_recovery_conferred_by_administration_of_kappa__and_delta_1_opioid_agonists_in_a_rat_model_of_global_ischemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9384(07)00403-9 DB - PRIME DP - Unbound Medicine ER -