Tags

Type your tag names separated by a space and hit enter

Immunomodulation by omega-3 fatty acids.
Prostaglandins Leukot Essent Fatty Acids. 2007 Nov-Dec; 77(5-6):327-35.PL

Abstract

The immune system, including its inflammatory components, is fundamental to host defense against pathogenic invaders. It is a complex system involving interactions amongst many different cell types dispersed throughout the body. Central to its actions are phagocytosis, processing of antigens derived from intracellular and extracellular pathogens, activation of T cells with proliferation and production of cytokines that elicit effector cell functions such as antibody production and killing cell activity. Inappropriate immunologic activity, including inflammation, is a characteristic of many common human disorders. Eicosanoids produced from arachidonic acid have roles in inflammation and regulation of T and B lymphocyte functions. Eicosapentaenoic acid (EPA) also gives rise to eicosanoids and docosahexaenoic acid (DHA) to docosanoids; these may have differing properties to arachidonic acid-derived eicosanoids. EPA and DHA give rise to newly discovered resolvins. Human immune cells are typically rich in arachidonic acid, but arachidonic acid, EPA and DHA contents can be altered through oral administration of those fatty acids. This results in a change pattern of production of eicosanoids and probably also of docosanoids and resolvins, although the latter are not well examined in the human context. Changing the fatty acid composition of immune cells also affects phagocytosis, T-cell signaling and antigen presentation capability. These effects appear to mediated at the membrane level suggesting important roles of fatty acids in membrane order, lipid raft structure and function and membrane trafficking.

Authors+Show Affiliations

Institute of Human Nutrition and School of Medicine, University of Southampton, Tremona Road, Southampton SO16 6YD, UK. pcc@soton.ac.uk

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18032006

Citation

Calder, Philip C.. "Immunomodulation By Omega-3 Fatty Acids." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 77, no. 5-6, 2007, pp. 327-35.
Calder PC. Immunomodulation by omega-3 fatty acids. Prostaglandins Leukot Essent Fatty Acids. 2007;77(5-6):327-35.
Calder, P. C. (2007). Immunomodulation by omega-3 fatty acids. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 77(5-6), 327-35.
Calder PC. Immunomodulation By Omega-3 Fatty Acids. Prostaglandins Leukot Essent Fatty Acids. 2007 Nov-Dec;77(5-6):327-35. PubMed PMID: 18032006.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunomodulation by omega-3 fatty acids. A1 - Calder,Philip C, Y1 - 2007/11/26/ PY - 2007/11/23/pubmed PY - 2008/4/24/medline PY - 2007/11/23/entrez SP - 327 EP - 35 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 77 IS - 5-6 N2 - The immune system, including its inflammatory components, is fundamental to host defense against pathogenic invaders. It is a complex system involving interactions amongst many different cell types dispersed throughout the body. Central to its actions are phagocytosis, processing of antigens derived from intracellular and extracellular pathogens, activation of T cells with proliferation and production of cytokines that elicit effector cell functions such as antibody production and killing cell activity. Inappropriate immunologic activity, including inflammation, is a characteristic of many common human disorders. Eicosanoids produced from arachidonic acid have roles in inflammation and regulation of T and B lymphocyte functions. Eicosapentaenoic acid (EPA) also gives rise to eicosanoids and docosahexaenoic acid (DHA) to docosanoids; these may have differing properties to arachidonic acid-derived eicosanoids. EPA and DHA give rise to newly discovered resolvins. Human immune cells are typically rich in arachidonic acid, but arachidonic acid, EPA and DHA contents can be altered through oral administration of those fatty acids. This results in a change pattern of production of eicosanoids and probably also of docosanoids and resolvins, although the latter are not well examined in the human context. Changing the fatty acid composition of immune cells also affects phagocytosis, T-cell signaling and antigen presentation capability. These effects appear to mediated at the membrane level suggesting important roles of fatty acids in membrane order, lipid raft structure and function and membrane trafficking. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/18032006/Immunomodulation_by_omega_3_fatty_acids_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(07)00141-X DB - PRIME DP - Unbound Medicine ER -