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Hepatic steatosis and fibrosis in chronic hepatitis C in Taiwan.
Jpn J Infect Dis 2007; 60(6):377-81JJ

Abstract

Hepatitis C virus (HCV) infection has been associated with hepatic steatosis. However, the role of hepatic steatosis in the pathogenesis of HCV infection remains controversial. In our study, 425 consecutive HCV-viremic patients with biopsy-proven chronic hepatitis C (male, 264; mean age, 49.0 years) were enrolled. Scoring of hepatic steatosis was based on the method described by Kleiner and on histopathology performed using the Knodell and Scheuer systems. HCV RNA level and genotypes were determined at the time of biopsy. Hepatic steatosis was observed in 30.8% of patients, including 113 mild, 16 moderate, and 3 with severe hepatic steatosis. Patients with a body mass index (BMI) <23 kg/m(2) had a significantly lower rate (18.9%) of hepatic steatosis (P<0.001). Hepatic steatosis did not correlate with the hepatic necroinflammatory activity, but was related to hepatic fibrosis (P=0.035). Hepatic steatosis was also not associated with HCV RNA level, and the distribution was similar between patients with HCV genotype 1 and genotype 2 infection. According to multivariate analysis, BMI is the strongest risk factor associated with hepatic steatosis, followed by hepatic fibrosis and triglyceride level with odds ratios (95% confidence intervals) of 2.51 (1.49-4.23), 2.06 (1.14-3.70), and 1.02 (1.01-1.03), respectively. Hepatic steatosis was associated with being overweight, hepatic fibrosis, and triglyceride level in chronic hepatitis C.

Authors+Show Affiliations

Department of Occupational and Environmental Medicine, Kaohsiung Municipal HsiaoKang Hospital, Kaohsiung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18032828

Citation

Hsieh, Meng-Hsuan, et al. "Hepatic Steatosis and Fibrosis in Chronic Hepatitis C in Taiwan." Japanese Journal of Infectious Diseases, vol. 60, no. 6, 2007, pp. 377-81.
Hsieh MH, Lee LP, Hsieh MY, et al. Hepatic steatosis and fibrosis in chronic hepatitis C in Taiwan. Jpn J Infect Dis. 2007;60(6):377-81.
Hsieh, M. H., Lee, L. P., Hsieh, M. Y., Tsai, K. B., Huang, J. F., Hou, N. J., ... Yu, M. L. (2007). Hepatic steatosis and fibrosis in chronic hepatitis C in Taiwan. Japanese Journal of Infectious Diseases, 60(6), pp. 377-81.
Hsieh MH, et al. Hepatic Steatosis and Fibrosis in Chronic Hepatitis C in Taiwan. Jpn J Infect Dis. 2007;60(6):377-81. PubMed PMID: 18032828.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatic steatosis and fibrosis in chronic hepatitis C in Taiwan. AU - Hsieh,Meng-Hsuan, AU - Lee,Li-Po, AU - Hsieh,Ming-Yen, AU - Tsai,Kun-Bow, AU - Huang,Jee-Fu, AU - Hou,Nai-Jen, AU - Chen,Shinn-Chern, AU - Lin,Zu-Yau, AU - Hsieh,Ming-Yuh, AU - Wang,Liang-Yen, AU - Dai,Chia-Yen, AU - Chuang,Wan-Long, AU - Yu,Ming-Lung, PY - 2007/11/23/pubmed PY - 2008/2/6/medline PY - 2007/11/23/entrez SP - 377 EP - 81 JF - Japanese journal of infectious diseases JO - Jpn. J. Infect. Dis. VL - 60 IS - 6 N2 - Hepatitis C virus (HCV) infection has been associated with hepatic steatosis. However, the role of hepatic steatosis in the pathogenesis of HCV infection remains controversial. In our study, 425 consecutive HCV-viremic patients with biopsy-proven chronic hepatitis C (male, 264; mean age, 49.0 years) were enrolled. Scoring of hepatic steatosis was based on the method described by Kleiner and on histopathology performed using the Knodell and Scheuer systems. HCV RNA level and genotypes were determined at the time of biopsy. Hepatic steatosis was observed in 30.8% of patients, including 113 mild, 16 moderate, and 3 with severe hepatic steatosis. Patients with a body mass index (BMI) <23 kg/m(2) had a significantly lower rate (18.9%) of hepatic steatosis (P<0.001). Hepatic steatosis did not correlate with the hepatic necroinflammatory activity, but was related to hepatic fibrosis (P=0.035). Hepatic steatosis was also not associated with HCV RNA level, and the distribution was similar between patients with HCV genotype 1 and genotype 2 infection. According to multivariate analysis, BMI is the strongest risk factor associated with hepatic steatosis, followed by hepatic fibrosis and triglyceride level with odds ratios (95% confidence intervals) of 2.51 (1.49-4.23), 2.06 (1.14-3.70), and 1.02 (1.01-1.03), respectively. Hepatic steatosis was associated with being overweight, hepatic fibrosis, and triglyceride level in chronic hepatitis C. SN - 1344-6304 UR - https://www.unboundmedicine.com/medline/citation/18032828/Hepatic_steatosis_and_fibrosis_in_chronic_hepatitis_C_in_Taiwan_ L2 - http://www0.nih.go.jp/JJID/60/377.html DB - PRIME DP - Unbound Medicine ER -