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Carcinogenetic impact of ADH1B and ALDH2 genes on squamous cell carcinoma risk of the esophagus with regard to the consumption of alcohol, tobacco and betel quid.
Int J Cancer. 2008 Mar 15; 122(6):1347-56.IJ

Abstract

The consumption of alcohol, tobacco and betel quid has been found to be an important contributor to esophageal squamous cell carcinoma (ESCC) in Taiwan. The genotoxic effect of the ADH1B and ALDH2 genes modulating an individual's alcohol-metabolizing capacity on ESCC may be linked to drinking behavior, intake pattern and other exogenous factors. To investigate the interplay of these genetic and environmental factors in determining the risk of ESCC, a multicenter case-control study was conducted. Here, 406 patients with pathology-proven ESCC, as well as 656 gender, age and study hospital matched controls were recruited. Genetic polymorphisms of ADH1B and ALDH2 appeared to correlate with the abstinence of alcohol, though not with tobacco and betel quid. Within the same levels of alcohol consumption, carcinoma risks increased along with an increase in the numbers of ADH1B*1 and ALDH2*2 alleles. The inactive ALDH2*1/*2 genotype was found to multiplicatively interact with a low-to-moderate (0.1-30 g/day) and a heavy (>30 g/day) ethanol intake to increase the ESCC risk (the joint aOR = 14.5 and 102.6, respectively). Among low-to-moderate drinkers, a smoking-dependent carcinogenetic effect for the ADH1B*1/*1 and ALDH2*1/*2+*2/*2 genotypes was recognized, with significant risks found in smokers, but not in nonsmokers. Further, a supra-multiplicative combined risk of ESCC for alcohol and tobacco use was identified among carriers of the ADH1B*1/*1 genotype (p for interaction = 0.042). In conclusion, the interplay of the ADH1B and ALDH2 genotypes, in conjunction with a behaved drinking habit and a practiced drinking pattern, along with continued tobacco consumption, plays an important pathogenic role in modulating ESCC risk.

Authors+Show Affiliations

Faculty of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18033686

Citation

Lee, Chien-Hung, et al. "Carcinogenetic Impact of ADH1B and ALDH2 Genes On Squamous Cell Carcinoma Risk of the Esophagus With Regard to the Consumption of Alcohol, Tobacco and Betel Quid." International Journal of Cancer, vol. 122, no. 6, 2008, pp. 1347-56.
Lee CH, Lee JM, Wu DC, et al. Carcinogenetic impact of ADH1B and ALDH2 genes on squamous cell carcinoma risk of the esophagus with regard to the consumption of alcohol, tobacco and betel quid. Int J Cancer. 2008;122(6):1347-56.
Lee, C. H., Lee, J. M., Wu, D. C., Goan, Y. G., Chou, S. H., Wu, I. C., Kao, E. L., Chan, T. F., Huang, M. C., Chen, P. S., Lee, C. Y., Huang, C. T., Huang, H. L., Hu, C. Y., Hung, Y. H., & Wu, M. T. (2008). Carcinogenetic impact of ADH1B and ALDH2 genes on squamous cell carcinoma risk of the esophagus with regard to the consumption of alcohol, tobacco and betel quid. International Journal of Cancer, 122(6), 1347-56.
Lee CH, et al. Carcinogenetic Impact of ADH1B and ALDH2 Genes On Squamous Cell Carcinoma Risk of the Esophagus With Regard to the Consumption of Alcohol, Tobacco and Betel Quid. Int J Cancer. 2008 Mar 15;122(6):1347-56. PubMed PMID: 18033686.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carcinogenetic impact of ADH1B and ALDH2 genes on squamous cell carcinoma risk of the esophagus with regard to the consumption of alcohol, tobacco and betel quid. AU - Lee,Chien-Hung, AU - Lee,Jang-Ming, AU - Wu,Deng-Chyang, AU - Goan,Yih-Gang, AU - Chou,Shah-Hwa, AU - Wu,I-Chen, AU - Kao,Ein-Long, AU - Chan,Te-Fu, AU - Huang,Meng-Chuan, AU - Chen,Pei-Shih, AU - Lee,Chun-Ying, AU - Huang,Chia-Tsuan, AU - Huang,Hsiao-Ling, AU - Hu,Chih-Yang, AU - Hung,Yu-Hsiu, AU - Wu,Ming-Tsang, PY - 2007/11/23/pubmed PY - 2008/4/2/medline PY - 2007/11/23/entrez SP - 1347 EP - 56 JF - International journal of cancer JO - Int J Cancer VL - 122 IS - 6 N2 - The consumption of alcohol, tobacco and betel quid has been found to be an important contributor to esophageal squamous cell carcinoma (ESCC) in Taiwan. The genotoxic effect of the ADH1B and ALDH2 genes modulating an individual's alcohol-metabolizing capacity on ESCC may be linked to drinking behavior, intake pattern and other exogenous factors. To investigate the interplay of these genetic and environmental factors in determining the risk of ESCC, a multicenter case-control study was conducted. Here, 406 patients with pathology-proven ESCC, as well as 656 gender, age and study hospital matched controls were recruited. Genetic polymorphisms of ADH1B and ALDH2 appeared to correlate with the abstinence of alcohol, though not with tobacco and betel quid. Within the same levels of alcohol consumption, carcinoma risks increased along with an increase in the numbers of ADH1B*1 and ALDH2*2 alleles. The inactive ALDH2*1/*2 genotype was found to multiplicatively interact with a low-to-moderate (0.1-30 g/day) and a heavy (>30 g/day) ethanol intake to increase the ESCC risk (the joint aOR = 14.5 and 102.6, respectively). Among low-to-moderate drinkers, a smoking-dependent carcinogenetic effect for the ADH1B*1/*1 and ALDH2*1/*2+*2/*2 genotypes was recognized, with significant risks found in smokers, but not in nonsmokers. Further, a supra-multiplicative combined risk of ESCC for alcohol and tobacco use was identified among carriers of the ADH1B*1/*1 genotype (p for interaction = 0.042). In conclusion, the interplay of the ADH1B and ALDH2 genotypes, in conjunction with a behaved drinking habit and a practiced drinking pattern, along with continued tobacco consumption, plays an important pathogenic role in modulating ESCC risk. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/18033686/Carcinogenetic_impact_of_ADH1B_and_ALDH2_genes_on_squamous_cell_carcinoma_risk_of_the_esophagus_with_regard_to_the_consumption_of_alcohol_tobacco_and_betel_quid_ L2 - https://doi.org/10.1002/ijc.23264 DB - PRIME DP - Unbound Medicine ER -