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Adverse effects from multi-drug therapy in leprosy: a Brazilian study.
Lepr Rev. 2007 Sep; 78(3):216-22.LR

Abstract

INTRODUCTION

The WHO MDT for leprosy treatment was officially introduced in Brazil in 1991 and comprises three drugs: dapsone, rifampicin and clofazimine. There are few good studies on the frequency of side-effects attributable to MDT in Brazil.

METHODS

A retrospective and descriptive study carried out in a LCP in Vitória, State of Espirito Santo, Brazil. A specific and detailed protocol about side-effects was prepared and filled in from the patient records.

RESULTS

One hundred ninety four patients' records were analysed looking for side-effects attributable to MDT. Side-effects were attributed to at least one MDT component in 88 (45%) patients and 85 had side-effects due to dapsone, 24 due to rifampicin and 18 due to clofazimine. 185 episodes were identified. The suspected drug was stopped in 47 out of 88 episodes (24% patients); 46 had dapsone stopped, 5 had rifampicin stopped and no-one had clofazimine stopped.

CONCLUSION

Side-effects attributed to MDT is more frequent than previously described, resulting in interruption of treatment in many patients.

Authors+Show Affiliations

Departamento de Medicina Social, Centro de Ciências da Saúde, Federal University of Espirito Santo, Maruípe, Vitória-ES, Brasil. pdeps@uol.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18035772

Citation

Deps, Patricia D., et al. "Adverse Effects From Multi-drug Therapy in Leprosy: a Brazilian Study." Leprosy Review, vol. 78, no. 3, 2007, pp. 216-22.
Deps PD, Nasser S, Guerra P, et al. Adverse effects from multi-drug therapy in leprosy: a Brazilian study. Lepr Rev. 2007;78(3):216-22.
Deps, P. D., Nasser, S., Guerra, P., Simon, M., Birshner, R. d. e. . C., & Rodrigues, L. C. (2007). Adverse effects from multi-drug therapy in leprosy: a Brazilian study. Leprosy Review, 78(3), 216-22.
Deps PD, et al. Adverse Effects From Multi-drug Therapy in Leprosy: a Brazilian Study. Lepr Rev. 2007;78(3):216-22. PubMed PMID: 18035772.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adverse effects from multi-drug therapy in leprosy: a Brazilian study. AU - Deps,Patricia D, AU - Nasser,Sofia, AU - Guerra,Patricia, AU - Simon,Marisa, AU - Birshner,Rita De Cássia, AU - Rodrigues,Laura C, PY - 2007/11/27/pubmed PY - 2008/1/9/medline PY - 2007/11/27/entrez SP - 216 EP - 22 JF - Leprosy review JO - Lepr Rev VL - 78 IS - 3 N2 - INTRODUCTION: The WHO MDT for leprosy treatment was officially introduced in Brazil in 1991 and comprises three drugs: dapsone, rifampicin and clofazimine. There are few good studies on the frequency of side-effects attributable to MDT in Brazil. METHODS: A retrospective and descriptive study carried out in a LCP in Vitória, State of Espirito Santo, Brazil. A specific and detailed protocol about side-effects was prepared and filled in from the patient records. RESULTS: One hundred ninety four patients' records were analysed looking for side-effects attributable to MDT. Side-effects were attributed to at least one MDT component in 88 (45%) patients and 85 had side-effects due to dapsone, 24 due to rifampicin and 18 due to clofazimine. 185 episodes were identified. The suspected drug was stopped in 47 out of 88 episodes (24% patients); 46 had dapsone stopped, 5 had rifampicin stopped and no-one had clofazimine stopped. CONCLUSION: Side-effects attributed to MDT is more frequent than previously described, resulting in interruption of treatment in many patients. SN - 0305-7518 UR - https://www.unboundmedicine.com/medline/citation/18035772/Adverse_effects_from_multi_drug_therapy_in_leprosy:_a_Brazilian_study_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -