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Vasoactive factors and hemodynamic mechanisms in the pathophysiology of portal hypertension in cirrhosis.
Mol Aspects Med. 2008 Feb-Apr; 29(1-2):119-29.MA

Abstract

Portal hypertension is primarily caused by the increase in resistance to portal outflow and secondly by an increase in splanchnic blood flow, which worsens and maintains the increased portal pressure. Increased portal inflow plays a role in the hyperdynamic circulatory syndrome, a characteristic feature of portal hypertensive patients. Almost all the known vasoactive systems/substances are activated in portal hypertension, but most authors stress the pathogenetic role of endothelial factors, such as COX-derivatives, nitric oxide, carbon monoxide. Endothelial dysfunction is differentially involved in different vascular beds and consists in alteration in response both to vasodilators and to vasoconstrictors. Understanding the pathogenesis of portal hypertension could be of great utility in preventing and curing the complications of portal hypertension, such as esophageal varices, hepatic encephalopathy, ascites.

Authors+Show Affiliations

Gatta A
Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, 35128 Padova, Italy. angelo.gatta@unipd.it
Bolognesi M
No affiliation info available
Merkel C
No affiliation info available

MeSH

AnimalsCarbon MonoxideHemodynamicsHumansHypertension, PortalLiver CirrhosisNitric Oxide

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18036654

Citation

Gatta, Angelo, et al. "Vasoactive Factors and Hemodynamic Mechanisms in the Pathophysiology of Portal Hypertension in Cirrhosis." Molecular Aspects of Medicine, vol. 29, no. 1-2, 2008, pp. 119-29.
Gatta A, Bolognesi M, Merkel C. Vasoactive factors and hemodynamic mechanisms in the pathophysiology of portal hypertension in cirrhosis. Mol Aspects Med. 2008;29(1-2):119-29.
Gatta, A., Bolognesi, M., & Merkel, C. (2008). Vasoactive factors and hemodynamic mechanisms in the pathophysiology of portal hypertension in cirrhosis. Molecular Aspects of Medicine, 29(1-2), 119-29.
Gatta A, Bolognesi M, Merkel C. Vasoactive Factors and Hemodynamic Mechanisms in the Pathophysiology of Portal Hypertension in Cirrhosis. Mol Aspects Med. 2008 Feb-Apr;29(1-2):119-29. PubMed PMID: 18036654.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vasoactive factors and hemodynamic mechanisms in the pathophysiology of portal hypertension in cirrhosis. AU - Gatta,Angelo, AU - Bolognesi,Massimo, AU - Merkel,Carlo, Y1 - 2007/10/24/ PY - 2007/08/30/received PY - 2007/09/28/accepted PY - 2007/11/27/pubmed PY - 2008/7/22/medline PY - 2007/11/27/entrez SP - 119 EP - 29 JF - Molecular aspects of medicine JO - Mol Aspects Med VL - 29 IS - 1-2 N2 - Portal hypertension is primarily caused by the increase in resistance to portal outflow and secondly by an increase in splanchnic blood flow, which worsens and maintains the increased portal pressure. Increased portal inflow plays a role in the hyperdynamic circulatory syndrome, a characteristic feature of portal hypertensive patients. Almost all the known vasoactive systems/substances are activated in portal hypertension, but most authors stress the pathogenetic role of endothelial factors, such as COX-derivatives, nitric oxide, carbon monoxide. Endothelial dysfunction is differentially involved in different vascular beds and consists in alteration in response both to vasodilators and to vasoconstrictors. Understanding the pathogenesis of portal hypertension could be of great utility in preventing and curing the complications of portal hypertension, such as esophageal varices, hepatic encephalopathy, ascites. SN - 0098-2997 UR - https://www.unboundmedicine.com/medline/citation/18036654/Vasoactive_factors_and_hemodynamic_mechanisms_in_the_pathophysiology_of_portal_hypertension_in_cirrhosis_ DB - PRIME DP - Unbound Medicine ER -