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Adrenal stress hormones, amygdala activation, and memory for emotionally arousing experiences.
Prog Brain Res. 2008; 167:79-97.PB

Abstract

Extensive evidence indicates that stress hormones released from the adrenal glands are critically involved in memory consolidation of emotionally arousing experiences. Epinephrine or glucocorticoids administered after exposure to emotionally arousing experiences enhance the consolidation of long-term memories of these experiences. Our findings indicate that adrenal stress hormones influence memory consolidation via interactions with arousal-induced activation of noradrenergic mechanisms within the amygdala. In turn, the amygdala regulates memory consolidation via its efferent projections to many other brain regions. In contrast to the enhancing effects on consolidation, high circulating levels of stress hormones impair memory retrieval and working memory. Such effects also require noradrenergic activation of the amygdala and interactions with other brain regions.

Authors+Show Affiliations

Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-3800, USA. broozend@uci.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

18037008

Citation

Roozendaal, Benno, et al. "Adrenal Stress Hormones, Amygdala Activation, and Memory for Emotionally Arousing Experiences." Progress in Brain Research, vol. 167, 2008, pp. 79-97.
Roozendaal B, Barsegyan A, Lee S. Adrenal stress hormones, amygdala activation, and memory for emotionally arousing experiences. Prog Brain Res. 2008;167:79-97.
Roozendaal, B., Barsegyan, A., & Lee, S. (2008). Adrenal stress hormones, amygdala activation, and memory for emotionally arousing experiences. Progress in Brain Research, 167, 79-97.
Roozendaal B, Barsegyan A, Lee S. Adrenal Stress Hormones, Amygdala Activation, and Memory for Emotionally Arousing Experiences. Prog Brain Res. 2008;167:79-97. PubMed PMID: 18037008.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adrenal stress hormones, amygdala activation, and memory for emotionally arousing experiences. AU - Roozendaal,Benno, AU - Barsegyan,Areg, AU - Lee,Sangkwan, PY - 2007/11/27/pubmed PY - 2008/1/25/medline PY - 2007/11/27/entrez SP - 79 EP - 97 JF - Progress in brain research JO - Prog Brain Res VL - 167 N2 - Extensive evidence indicates that stress hormones released from the adrenal glands are critically involved in memory consolidation of emotionally arousing experiences. Epinephrine or glucocorticoids administered after exposure to emotionally arousing experiences enhance the consolidation of long-term memories of these experiences. Our findings indicate that adrenal stress hormones influence memory consolidation via interactions with arousal-induced activation of noradrenergic mechanisms within the amygdala. In turn, the amygdala regulates memory consolidation via its efferent projections to many other brain regions. In contrast to the enhancing effects on consolidation, high circulating levels of stress hormones impair memory retrieval and working memory. Such effects also require noradrenergic activation of the amygdala and interactions with other brain regions. SN - 0079-6123 UR - https://www.unboundmedicine.com/medline/citation/18037008/Adrenal_stress_hormones_amygdala_activation_and_memory_for_emotionally_arousing_experiences_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0079-6123(07)67006-X DB - PRIME DP - Unbound Medicine ER -