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Acute inflammatory response does not affect erythrocyte concentrations of copper, zinc and selenium.
Clin Nutr 2008; 27(1):115-20CN

Abstract

BACKGROUND & AIMS

Measuring the nutritional status of trace elements in plasma is invalidated in the presence of a systemic inflammatory response. We examined the potential of erythrocytes to assess copper, zinc and selenium status in such situations.

METHODS

Venous blood samples were withdrawn pre-operatively and at 12, 24, 48, 72 and 168 h post-operatively from 11 patients (6 males and 5 females) who were admitted for elective knee arthroplasty. C-reactive protein, albumin, copper, zinc, selenium and iron were measured in plasma and erythrocytes.

RESULTS

Plasma zinc and selenium concentrations fell significantly: 95% confidence intervals (CI)=-32% to -44% and -22% to -36%, respectively. Copper concentrations fell transiently and then increased significantly: CI=12-43%. No significant changes were seen in trace element concentrations in erythrocytes expressed either as a ratio of haemoglobin or iron concentration. Erythrocyte iron levels correlated significantly with haemoglobin (r=0.93).

CONCLUSIONS

Plasma concentrations of copper, zinc and selenium are unreliable markers of status in patients with an acute inflammatory response. Erythrocyte concentrations of these trace elements may provide a more reliable measure in long-term studies of patients with a chronic systemic inflammatory response. Iron can be used instead of haemoglobin as the denominator when expressing erythrocyte concentrations of trace elements.

Authors+Show Affiliations

Scottish Trace Element and Micronutrient Reference Laboratory, Royal Infirmary, Glasgow G4 0SF, UK. eleanor.oakes@nhs.net

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18037540

Citation

Oakes, Eleanor J C., et al. "Acute Inflammatory Response Does Not Affect Erythrocyte Concentrations of Copper, Zinc and Selenium." Clinical Nutrition (Edinburgh, Scotland), vol. 27, no. 1, 2008, pp. 115-20.
Oakes EJ, Lyon TD, Duncan A, et al. Acute inflammatory response does not affect erythrocyte concentrations of copper, zinc and selenium. Clin Nutr. 2008;27(1):115-20.
Oakes, E. J., Lyon, T. D., Duncan, A., Gray, A., Talwar, D., & O'Reilly, D. S. (2008). Acute inflammatory response does not affect erythrocyte concentrations of copper, zinc and selenium. Clinical Nutrition (Edinburgh, Scotland), 27(1), pp. 115-20.
Oakes EJ, et al. Acute Inflammatory Response Does Not Affect Erythrocyte Concentrations of Copper, Zinc and Selenium. Clin Nutr. 2008;27(1):115-20. PubMed PMID: 18037540.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute inflammatory response does not affect erythrocyte concentrations of copper, zinc and selenium. AU - Oakes,Eleanor J C, AU - Lyon,Thomas D B, AU - Duncan,Andrew, AU - Gray,Andrew, AU - Talwar,Dinesh, AU - O'Reilly,Denis St J, Y1 - 2007/11/26/ PY - 2007/02/20/received PY - 2007/07/20/revised PY - 2007/10/10/accepted PY - 2007/11/27/pubmed PY - 2008/3/18/medline PY - 2007/11/27/entrez SP - 115 EP - 20 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 27 IS - 1 N2 - BACKGROUND & AIMS: Measuring the nutritional status of trace elements in plasma is invalidated in the presence of a systemic inflammatory response. We examined the potential of erythrocytes to assess copper, zinc and selenium status in such situations. METHODS: Venous blood samples were withdrawn pre-operatively and at 12, 24, 48, 72 and 168 h post-operatively from 11 patients (6 males and 5 females) who were admitted for elective knee arthroplasty. C-reactive protein, albumin, copper, zinc, selenium and iron were measured in plasma and erythrocytes. RESULTS: Plasma zinc and selenium concentrations fell significantly: 95% confidence intervals (CI)=-32% to -44% and -22% to -36%, respectively. Copper concentrations fell transiently and then increased significantly: CI=12-43%. No significant changes were seen in trace element concentrations in erythrocytes expressed either as a ratio of haemoglobin or iron concentration. Erythrocyte iron levels correlated significantly with haemoglobin (r=0.93). CONCLUSIONS: Plasma concentrations of copper, zinc and selenium are unreliable markers of status in patients with an acute inflammatory response. Erythrocyte concentrations of these trace elements may provide a more reliable measure in long-term studies of patients with a chronic systemic inflammatory response. Iron can be used instead of haemoglobin as the denominator when expressing erythrocyte concentrations of trace elements. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/18037540/Acute_inflammatory_response_does_not_affect_erythrocyte_concentrations_of_copper_zinc_and_selenium_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(07)00167-7 DB - PRIME DP - Unbound Medicine ER -