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Induction of parkinsonian resting tremor by stimulation of the caudal zona incerta nucleus: a clinical study.
J Neurol Neurosurg Psychiatry. 2008 May; 79(5):514-21.JN

Abstract

INTRODUCTION

We hypothesise that parkinsonian tremor arises when the caudal zona incerta (cZI) and subthalamic nucleus (STN) are deprived of dopamine and become increasingly responsive to motor cortical alpha and beta frequency oscillations. These oscillations are synchronised and amplified through the basal ganglia thalamocortical loop and entrained into the cerebello-thalamocortical loop via the cZI. On receiving potent gamma-aminobutyric acid (GABA)-ergic alpha and beta frequency oscillations in cZI afferents, ventrolateral (VL) thalamocortical neurons become hyperpolarised and rebound burst fire, generating 4-6 Hz tremor oscillations. We test this hypothesis by stimulating the cZI at alpha and beta frequencies using deep brain stimulation (DBS) in non-tremulous parkinsonian patients to see whether a 4-6 Hz tremor can be induced.

METHOD

This study included 11 patients with non-tremulous Parkinson's disease (PD), who had DBS leads implanted in a range of targets, including the cZI, STN, VL nucleus, globus pallidus internus (GPi), centromedian and parafascicular nucleus (CM/Pf), and the pedunculopontine nucleus (PPN). All patients underwent stimulation of active contacts within their respective targets at a standard pulse width, with frequencies ranging from 5 to 80 Hz up to a maximum tolerated voltage. The frequency of the tremor induced in the hands was recorded by accelerometry.

RESULT

Resting tremor in the 4-6 Hz range could be readily induced following stimulation of the cZI and the VL nucleus between 5 and 40 Hz. Tremor was also seen following STN stimulation; however, this was only at high stimulation voltages (>5 volts). No tremor could be induced following CM/Pf, PPN or GPi stimulation.

CONCLUSION

We discuss the implications of these findings and argue that resting tremor in PD is generated in the cortico-ZI-VL-thalamocortical loop rather than in the cortico-basal-ganglia-thalamocortical loop.

Authors+Show Affiliations

Institute of Neurosciences, Department of Neurosurgery, Frenchay Hospital, Bristol BS16 1LE, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18037629

Citation

Plaha, P, et al. "Induction of Parkinsonian Resting Tremor By Stimulation of the Caudal Zona Incerta Nucleus: a Clinical Study." Journal of Neurology, Neurosurgery, and Psychiatry, vol. 79, no. 5, 2008, pp. 514-21.
Plaha P, Filipovic S, Gill SS. Induction of parkinsonian resting tremor by stimulation of the caudal zona incerta nucleus: a clinical study. J Neurol Neurosurg Psychiatry. 2008;79(5):514-21.
Plaha, P., Filipovic, S., & Gill, S. S. (2008). Induction of parkinsonian resting tremor by stimulation of the caudal zona incerta nucleus: a clinical study. Journal of Neurology, Neurosurgery, and Psychiatry, 79(5), 514-21.
Plaha P, Filipovic S, Gill SS. Induction of Parkinsonian Resting Tremor By Stimulation of the Caudal Zona Incerta Nucleus: a Clinical Study. J Neurol Neurosurg Psychiatry. 2008;79(5):514-21. PubMed PMID: 18037629.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Induction of parkinsonian resting tremor by stimulation of the caudal zona incerta nucleus: a clinical study. AU - Plaha,P, AU - Filipovic,S, AU - Gill,S S, Y1 - 2007/11/23/ PY - 2007/11/27/pubmed PY - 2008/4/30/medline PY - 2007/11/27/entrez SP - 514 EP - 21 JF - Journal of neurology, neurosurgery, and psychiatry JO - J Neurol Neurosurg Psychiatry VL - 79 IS - 5 N2 - INTRODUCTION: We hypothesise that parkinsonian tremor arises when the caudal zona incerta (cZI) and subthalamic nucleus (STN) are deprived of dopamine and become increasingly responsive to motor cortical alpha and beta frequency oscillations. These oscillations are synchronised and amplified through the basal ganglia thalamocortical loop and entrained into the cerebello-thalamocortical loop via the cZI. On receiving potent gamma-aminobutyric acid (GABA)-ergic alpha and beta frequency oscillations in cZI afferents, ventrolateral (VL) thalamocortical neurons become hyperpolarised and rebound burst fire, generating 4-6 Hz tremor oscillations. We test this hypothesis by stimulating the cZI at alpha and beta frequencies using deep brain stimulation (DBS) in non-tremulous parkinsonian patients to see whether a 4-6 Hz tremor can be induced. METHOD: This study included 11 patients with non-tremulous Parkinson's disease (PD), who had DBS leads implanted in a range of targets, including the cZI, STN, VL nucleus, globus pallidus internus (GPi), centromedian and parafascicular nucleus (CM/Pf), and the pedunculopontine nucleus (PPN). All patients underwent stimulation of active contacts within their respective targets at a standard pulse width, with frequencies ranging from 5 to 80 Hz up to a maximum tolerated voltage. The frequency of the tremor induced in the hands was recorded by accelerometry. RESULT: Resting tremor in the 4-6 Hz range could be readily induced following stimulation of the cZI and the VL nucleus between 5 and 40 Hz. Tremor was also seen following STN stimulation; however, this was only at high stimulation voltages (>5 volts). No tremor could be induced following CM/Pf, PPN or GPi stimulation. CONCLUSION: We discuss the implications of these findings and argue that resting tremor in PD is generated in the cortico-ZI-VL-thalamocortical loop rather than in the cortico-basal-ganglia-thalamocortical loop. SN - 1468-330X UR - https://www.unboundmedicine.com/medline/citation/18037629/Induction_of_parkinsonian_resting_tremor_by_stimulation_of_the_caudal_zona_incerta_nucleus:_a_clinical_study_ L2 - https://jnnp.bmj.com/lookup/pmidlookup?view=long&pmid=18037629 DB - PRIME DP - Unbound Medicine ER -