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Updating of normal levels of copper, zinc and selenium in serum of pregnant women.
J Trace Elem Med Biol. 2007; 21 Suppl 1:49-52.JT

Abstract

Selenium, copper and zinc status is important in pregnant women. The aim of this study was to establish updated normal ranges for these elements in serum of pregnant women from the Spanish region of Aragon, and to study variation in levels with respect to gestational period and maternal age. The study group consisted of 159 pregnant women who did not suffer from serious pathologies. These samples were classified into four gestational-period groups. Zn and Cu determinations were obtained by flame atomic absorption spectroscopy in a Perkin-Elmer 1100B apparatus, and Se was determined by electrothermal atomic absorption spectrometry with Zeeman correction, in a Perkin-Elmer 4110 ZL apparatus. The concentrations of Cu, Zn and Se averaged 73.61+/-43.67 microg/dL, 65.37+/-12.87 microg/dL and 99.59+/-21.74 microg/L, respectively. The Cu/Zn ratio increased from first trimester to the third trimester (2.07-3.49). There was no significant correlation between Zn and Se levels, but a significant correlation was found between Cu and Se levels (p<0.05) and between Cu and Zn levels (p<0.001). Serum Zn and Se levels decreased over gestation, while serum Cu concentrations increased; in all cases the variation occurred mostly in the first 3 or 4 months, with mean levels then remaining fairly stable until the end of pregnancy. Maternal age did not influence levels of any of the three metals.

Authors+Show Affiliations

Servicio de Bioquímica Clínica, Hospital Universitario Miguel Servet, Paseo Isabel la Católica 1-3, 50009 Zaragoza, Spain. sizquierdo@salud.aragon.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18039497

Citation

Izquierdo Alvarez, Silvia, et al. "Updating of Normal Levels of Copper, Zinc and Selenium in Serum of Pregnant Women." Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), vol. 21 Suppl 1, 2007, pp. 49-52.
Izquierdo Alvarez S, Castañón SG, Ruata ML, et al. Updating of normal levels of copper, zinc and selenium in serum of pregnant women. J Trace Elem Med Biol. 2007;21 Suppl 1:49-52.
Izquierdo Alvarez, S., Castañón, S. G., Ruata, M. L., Aragüés, E. F., Terraz, P. B., Irazabal, Y. G., González, E. G., & Rodríguez, B. G. (2007). Updating of normal levels of copper, zinc and selenium in serum of pregnant women. Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), 21 Suppl 1, 49-52.
Izquierdo Alvarez S, et al. Updating of Normal Levels of Copper, Zinc and Selenium in Serum of Pregnant Women. J Trace Elem Med Biol. 2007;21 Suppl 1:49-52. PubMed PMID: 18039497.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Updating of normal levels of copper, zinc and selenium in serum of pregnant women. AU - Izquierdo Alvarez,Silvia, AU - Castañón,Sandra García, AU - Ruata,Maria Luisa Calvo, AU - Aragüés,Elena Fuertes, AU - Terraz,Pilar Bocos, AU - Irazabal,Yolanda González, AU - González,Elena García, AU - Rodríguez,Beatriz García, Y1 - 2007/11/07/ PY - 2007/06/29/received PY - 2007/08/30/accepted PY - 2007/12/6/pubmed PY - 2008/2/5/medline PY - 2007/12/6/entrez SP - 49 EP - 52 JF - Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) JO - J Trace Elem Med Biol VL - 21 Suppl 1 N2 - Selenium, copper and zinc status is important in pregnant women. The aim of this study was to establish updated normal ranges for these elements in serum of pregnant women from the Spanish region of Aragon, and to study variation in levels with respect to gestational period and maternal age. The study group consisted of 159 pregnant women who did not suffer from serious pathologies. These samples were classified into four gestational-period groups. Zn and Cu determinations were obtained by flame atomic absorption spectroscopy in a Perkin-Elmer 1100B apparatus, and Se was determined by electrothermal atomic absorption spectrometry with Zeeman correction, in a Perkin-Elmer 4110 ZL apparatus. The concentrations of Cu, Zn and Se averaged 73.61+/-43.67 microg/dL, 65.37+/-12.87 microg/dL and 99.59+/-21.74 microg/L, respectively. The Cu/Zn ratio increased from first trimester to the third trimester (2.07-3.49). There was no significant correlation between Zn and Se levels, but a significant correlation was found between Cu and Se levels (p<0.05) and between Cu and Zn levels (p<0.001). Serum Zn and Se levels decreased over gestation, while serum Cu concentrations increased; in all cases the variation occurred mostly in the first 3 or 4 months, with mean levels then remaining fairly stable until the end of pregnancy. Maternal age did not influence levels of any of the three metals. SN - 0946-672X UR - https://www.unboundmedicine.com/medline/citation/18039497/Updating_of_normal_levels_of_copper_zinc_and_selenium_in_serum_of_pregnant_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0946-672X(07)00117-4 DB - PRIME DP - Unbound Medicine ER -