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Changes in motor cortical excitability induced by high-frequency repetitive transcranial magnetic stimulation of different stimulation durations.
Clin Neurophysiol 2008; 119(1):71-9CN

Abstract

OBJECTIVE

To investigate the changes in cortical excitability of the human motor cortex induced by high-frequency repetitive transcranial magnetic stimulation (rTMS) of different stimulation durations.

METHODS

Twenty healthy subjects participated in the study. Subjects received 20 trains of 10-Hz rTMS at 80% of the resting motor threshold (RMT) intensity with two different stimulation durations (5 and 1.5s) over the motor hot spot for left first dorsal interosseous (FDI) muscle. Electromyographic responses (motor-evoked potentials, MEPs) to single-pulse stimulation, and intracortical inhibition (ICI) and intracortical facilitation (ICF) by paired-pulse stimulation were measured bilaterally in the relaxed FDI muscles before, immediately after, and 30, 60, 90 and 120 min after rTMS.

RESULTS

After 5s of 10-Hz rTMS, the mean amplitude of MEP for the stimulated M1 cortex decreased for up to 90min (P=0.002) and that of the unstimulated M1 cortex decreased for up to 60 min (P=0.008). Enhancement of ICI and suppression of ICF were observed and sustained for more than 90 min in both stimulated (P=0.001) and unstimulated (P=0.003) M1 cortex after 5s of 10-Hz rTMS. After 1.5s of 10-Hz rTMS, the mean amplitude of MEP increased in stimulated cortex for up to 120 min (P=0.005).

CONCLUSIONS

With different stimulation durations, high-frequency subthreshold rTMS can produce different patterns of long-lasting changes in corticospinal and intracortical excitability in stimulated and unstimulated motor cortex in healthy subjects.

SIGNIFICANCE

The results have important implications for the selection of stimulation parameters other than the frequency of rTMS. The clinical application of rTMS for the purpose of motor enhancement should be considered along with the mechanism of different stimulation parameters.

Authors+Show Affiliations

Department of Rehabilitation Medicine, Seoul Metropolitan Boramae Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18039593

Citation

Jung, Se Hee, et al. "Changes in Motor Cortical Excitability Induced By High-frequency Repetitive Transcranial Magnetic Stimulation of Different Stimulation Durations." Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, vol. 119, no. 1, 2008, pp. 71-9.
Jung SH, Shin JE, Jeong YS, et al. Changes in motor cortical excitability induced by high-frequency repetitive transcranial magnetic stimulation of different stimulation durations. Clin Neurophysiol. 2008;119(1):71-9.
Jung, S. H., Shin, J. E., Jeong, Y. S., & Shin, H. I. (2008). Changes in motor cortical excitability induced by high-frequency repetitive transcranial magnetic stimulation of different stimulation durations. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 119(1), pp. 71-9.
Jung SH, et al. Changes in Motor Cortical Excitability Induced By High-frequency Repetitive Transcranial Magnetic Stimulation of Different Stimulation Durations. Clin Neurophysiol. 2008;119(1):71-9. PubMed PMID: 18039593.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in motor cortical excitability induced by high-frequency repetitive transcranial magnetic stimulation of different stimulation durations. AU - Jung,Se Hee, AU - Shin,Jae Eun, AU - Jeong,Yong-Seol, AU - Shin,Hyung-Ik, Y1 - 2007/11/26/ PY - 2007/03/25/received PY - 2007/09/16/revised PY - 2007/09/30/accepted PY - 2007/11/28/pubmed PY - 2008/4/12/medline PY - 2007/11/28/entrez SP - 71 EP - 9 JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology JO - Clin Neurophysiol VL - 119 IS - 1 N2 - OBJECTIVE: To investigate the changes in cortical excitability of the human motor cortex induced by high-frequency repetitive transcranial magnetic stimulation (rTMS) of different stimulation durations. METHODS: Twenty healthy subjects participated in the study. Subjects received 20 trains of 10-Hz rTMS at 80% of the resting motor threshold (RMT) intensity with two different stimulation durations (5 and 1.5s) over the motor hot spot for left first dorsal interosseous (FDI) muscle. Electromyographic responses (motor-evoked potentials, MEPs) to single-pulse stimulation, and intracortical inhibition (ICI) and intracortical facilitation (ICF) by paired-pulse stimulation were measured bilaterally in the relaxed FDI muscles before, immediately after, and 30, 60, 90 and 120 min after rTMS. RESULTS: After 5s of 10-Hz rTMS, the mean amplitude of MEP for the stimulated M1 cortex decreased for up to 90min (P=0.002) and that of the unstimulated M1 cortex decreased for up to 60 min (P=0.008). Enhancement of ICI and suppression of ICF were observed and sustained for more than 90 min in both stimulated (P=0.001) and unstimulated (P=0.003) M1 cortex after 5s of 10-Hz rTMS. After 1.5s of 10-Hz rTMS, the mean amplitude of MEP increased in stimulated cortex for up to 120 min (P=0.005). CONCLUSIONS: With different stimulation durations, high-frequency subthreshold rTMS can produce different patterns of long-lasting changes in corticospinal and intracortical excitability in stimulated and unstimulated motor cortex in healthy subjects. SIGNIFICANCE: The results have important implications for the selection of stimulation parameters other than the frequency of rTMS. The clinical application of rTMS for the purpose of motor enhancement should be considered along with the mechanism of different stimulation parameters. SN - 1388-2457 UR - https://www.unboundmedicine.com/medline/citation/18039593/Changes_in_motor_cortical_excitability_induced_by_high_frequency_repetitive_transcranial_magnetic_stimulation_of_different_stimulation_durations_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388-2457(07)00587-1 DB - PRIME DP - Unbound Medicine ER -