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Association between serum bioavailable testosterone concentration and the ratio of glycated albumin to glycated hemoglobin in men with type 2 diabetes.
Diabetes Care. 2008 Mar; 31(3):397-401.DC

Abstract

OBJECTIVE

Testosterone stimulates erythropoiesis and thus glycated hemoglobin (A1C) values may be relatively low in male diabetic patients with hypogonadism. We therefore investigated relationships between serum bioavailable testosterone concentration and the ratio of glycated albumin (GA) to A1C and between serum bioavailable testosterone and hemoglobin concentrations in men with type 2 diabetes.

RESEARCH DESIGN AND METHODS

The above relationships were investigated in 222 consecutive men with type 2 diabetes. We also investigated how the ratio of GA to A1C is related to other variables such as age, BMI, and degree of diabetic microangiopathy.

RESULTS

Mean ratio of GA to A1C was 2.94 +/- 0.38. Serum bioavailable testosterone concentration correlated positively with hemoglobin concentration (r = 0.368, P < 0.0001) and negatively with the ratio of GA to A1C (r = -0.278, P < 0.0001). Multiple regression analyses identified serum bioavailable testosterone concentration (beta = 0.187, P = 0.0062), age (beta = -0.204, P = 0.0075), BMI (beta = 0.151, P = 0.0302), systolic blood pressure (beta = 0.173, P = 0.0090), and plasma total cholesterol (beta = 0.155, P = 0.0141) as independent determinants of hemoglobin concentration; moreover, serum bioavailable testosterone concentration (beta = -0.155, P = 0.0381) and plasma total cholesterol (beta = -0.170, P = 0.0144) were identified as independent determinants of the ratio of GA to A1C.

CONCLUSIONS

Serum bioavailable testosterone concentration correlated positively with hemoglobin concentration and negatively with the ratio of GA to A1C in men with type 2 diabetes, which may lead to underestimation of A1C in hypogonadal men with type 2 diabetes.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan. sayarinapm@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18039803

Citation

Fukui, Michiaki, et al. "Association Between Serum Bioavailable Testosterone Concentration and the Ratio of Glycated Albumin to Glycated Hemoglobin in Men With Type 2 Diabetes." Diabetes Care, vol. 31, no. 3, 2008, pp. 397-401.
Fukui M, Tanaka M, Hasegawa G, et al. Association between serum bioavailable testosterone concentration and the ratio of glycated albumin to glycated hemoglobin in men with type 2 diabetes. Diabetes Care. 2008;31(3):397-401.
Fukui, M., Tanaka, M., Hasegawa, G., Yoshikawa, T., & Nakamura, N. (2008). Association between serum bioavailable testosterone concentration and the ratio of glycated albumin to glycated hemoglobin in men with type 2 diabetes. Diabetes Care, 31(3), 397-401.
Fukui M, et al. Association Between Serum Bioavailable Testosterone Concentration and the Ratio of Glycated Albumin to Glycated Hemoglobin in Men With Type 2 Diabetes. Diabetes Care. 2008;31(3):397-401. PubMed PMID: 18039803.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between serum bioavailable testosterone concentration and the ratio of glycated albumin to glycated hemoglobin in men with type 2 diabetes. AU - Fukui,Michiaki, AU - Tanaka,Muhei, AU - Hasegawa,Goji, AU - Yoshikawa,Toshikazu, AU - Nakamura,Naoto, Y1 - 2007/11/26/ PY - 2007/11/28/pubmed PY - 2008/6/3/medline PY - 2007/11/28/entrez SP - 397 EP - 401 JF - Diabetes care JO - Diabetes Care VL - 31 IS - 3 N2 - OBJECTIVE: Testosterone stimulates erythropoiesis and thus glycated hemoglobin (A1C) values may be relatively low in male diabetic patients with hypogonadism. We therefore investigated relationships between serum bioavailable testosterone concentration and the ratio of glycated albumin (GA) to A1C and between serum bioavailable testosterone and hemoglobin concentrations in men with type 2 diabetes. RESEARCH DESIGN AND METHODS: The above relationships were investigated in 222 consecutive men with type 2 diabetes. We also investigated how the ratio of GA to A1C is related to other variables such as age, BMI, and degree of diabetic microangiopathy. RESULTS: Mean ratio of GA to A1C was 2.94 +/- 0.38. Serum bioavailable testosterone concentration correlated positively with hemoglobin concentration (r = 0.368, P < 0.0001) and negatively with the ratio of GA to A1C (r = -0.278, P < 0.0001). Multiple regression analyses identified serum bioavailable testosterone concentration (beta = 0.187, P = 0.0062), age (beta = -0.204, P = 0.0075), BMI (beta = 0.151, P = 0.0302), systolic blood pressure (beta = 0.173, P = 0.0090), and plasma total cholesterol (beta = 0.155, P = 0.0141) as independent determinants of hemoglobin concentration; moreover, serum bioavailable testosterone concentration (beta = -0.155, P = 0.0381) and plasma total cholesterol (beta = -0.170, P = 0.0144) were identified as independent determinants of the ratio of GA to A1C. CONCLUSIONS: Serum bioavailable testosterone concentration correlated positively with hemoglobin concentration and negatively with the ratio of GA to A1C in men with type 2 diabetes, which may lead to underestimation of A1C in hypogonadal men with type 2 diabetes. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/18039803/Association_between_serum_bioavailable_testosterone_concentration_and_the_ratio_of_glycated_albumin_to_glycated_hemoglobin_in_men_with_type_2_diabetes_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=18039803 DB - PRIME DP - Unbound Medicine ER -