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Pre-operative prediction of serum CA125 level in women with ovarian masses.
J Med Assoc Thai. 2007 Oct; 90(10):1986-91.JM

Abstract

OBJECTIVE

To assess the accuracy of serum CA125 at the level of more than 35 U/mL in predicting ovarian cancer using histopathology as a gold standard.

MATERIAL AND METHOD

Blood samples were obtained from 120 women with ovarian masses scheduled for elective surgery at Siriraj Hospital between October 1, 2003 and August 31, 2004 and sent for the assay of serum CA125 levels.

RESULTS

Of the 120 women enrolled, ovarian cancer was found in 59 cases (49.2%) and benign ovarian mass in 61 cases (50.8%). The sensitivity, specificity, and accuracy of serum CA125 at the cutoff level of 35 U/mL for prediction of ovarian cancer were 83.1%, 39.3%, and 60.8%, respectively; with 57.0% positive predictive value, 70.6% negative predictive value, 60.7% false positive rate, and 16.9% false negative rate.

CONCLUSION

As stand-alone modality, serum CA125 of more than 35 U/mL in predicting ovarian cancer revealed modest diagnostic accuracy. There is a need to be careful for false positive in women at reproductive age group and false negative results in early-stage disease or ovarian cancer with low level of serum CA125.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18041413

Citation

Benjapibal, Mongkol, and Chanon Neungton. "Pre-operative Prediction of Serum CA125 Level in Women With Ovarian Masses." Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, vol. 90, no. 10, 2007, pp. 1986-91.
Benjapibal M, Neungton C. Pre-operative prediction of serum CA125 level in women with ovarian masses. J Med Assoc Thai. 2007;90(10):1986-91.
Benjapibal, M., & Neungton, C. (2007). Pre-operative prediction of serum CA125 level in women with ovarian masses. Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, 90(10), 1986-91.
Benjapibal M, Neungton C. Pre-operative Prediction of Serum CA125 Level in Women With Ovarian Masses. J Med Assoc Thai. 2007;90(10):1986-91. PubMed PMID: 18041413.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pre-operative prediction of serum CA125 level in women with ovarian masses. AU - Benjapibal,Mongkol, AU - Neungton,Chanon, PY - 2007/11/29/pubmed PY - 2008/1/9/medline PY - 2007/11/29/entrez SP - 1986 EP - 91 JF - Journal of the Medical Association of Thailand = Chotmaihet thangphaet JO - J Med Assoc Thai VL - 90 IS - 10 N2 - OBJECTIVE: To assess the accuracy of serum CA125 at the level of more than 35 U/mL in predicting ovarian cancer using histopathology as a gold standard. MATERIAL AND METHOD: Blood samples were obtained from 120 women with ovarian masses scheduled for elective surgery at Siriraj Hospital between October 1, 2003 and August 31, 2004 and sent for the assay of serum CA125 levels. RESULTS: Of the 120 women enrolled, ovarian cancer was found in 59 cases (49.2%) and benign ovarian mass in 61 cases (50.8%). The sensitivity, specificity, and accuracy of serum CA125 at the cutoff level of 35 U/mL for prediction of ovarian cancer were 83.1%, 39.3%, and 60.8%, respectively; with 57.0% positive predictive value, 70.6% negative predictive value, 60.7% false positive rate, and 16.9% false negative rate. CONCLUSION: As stand-alone modality, serum CA125 of more than 35 U/mL in predicting ovarian cancer revealed modest diagnostic accuracy. There is a need to be careful for false positive in women at reproductive age group and false negative results in early-stage disease or ovarian cancer with low level of serum CA125. SN - 0125-2208 UR - https://www.unboundmedicine.com/medline/citation/18041413/Pre_operative_prediction_of_serum_CA125_level_in_women_with_ovarian_masses_ L2 - https://medlineplus.gov/ovariancancer.html DB - PRIME DP - Unbound Medicine ER -