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Oseltamivir and the risk of influenza-related complications and hospitalizations in patients with diabetes.
Clin Ther. 2007 Oct; 29(10):2246-55.CT

Abstract

OBJECTIVE

This subgroup analysis of a retrospective cohort study examined, from a managed care perspective, the risk of influenza-related complications and hospitalizations in patients with diabetes who were prescribed oseltamivir for the treatment of influenza and those who were not prescribed antiviral treatment.

METHODS

Health insurance claims data from the Thomson Healthcare MarketScan Research Database for 6 influenza seasons (October 1-March 31) between 2000 and 2006 were used to identify patients aged >/=18 years with influenza and diabetes. Patients who received a prescription for oseltamivir within 1 day of a diagnosis of influenza were compared with those who received no antiviral treatment. Outcomes included the frequency of pneumonia, respiratory diagnoses, and otitis media and its complications, and rates of hospitalization within 14 days of the diagnosis of influenza. Cox proportional hazards regression was used to determine the relative risk (RR) of influenza-related complications and hospitalizations.

RESULTS

A total of 9090 patients with diabetes and a diagnosis of influenza were identified who met all study criteria. Of these, 2919 (32%) received a prescription for oseltamivir and 6171 (68%) received no antiviral treatment. Patients receiving oseltamivir had a significant 17% reduction in the risk of respiratory illnesses (RR = 0.83; 95% CI, 0.73-0.93) and a 30% reduction in the risk of hospitalization for any reason (RR = 0.70; 95% CI, 0.52-0.94). There were no significant differences between the oseltamivir and control groups in terms of the risks for pneumonia (RR = 0.87; 95% CI, 0.64-1.18), otitis media and its complications (RR = 0.96; 95% CI, 0.48-1.91), or hospitalization for pneumonia (RR = 0.81; 95% CI, 0.41-1.58).

CONCLUSION

In this retrospective study, the risk of influenza-associated respiratory illnesses and the number of hospitalizations for any reason were reduced in patients with diabetes who were prescribed oseltamivir compared with an unmatched group that was not prescribed antiviral therapy.

Authors+Show Affiliations

Baylor College of Medicine, Houston, Texas, USA. eric@orzeck.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18042482

Citation

Orzeck, Eric A., et al. "Oseltamivir and the Risk of Influenza-related Complications and Hospitalizations in Patients With Diabetes." Clinical Therapeutics, vol. 29, no. 10, 2007, pp. 2246-55.
Orzeck EA, Shi N, Blumentals WA. Oseltamivir and the risk of influenza-related complications and hospitalizations in patients with diabetes. Clin Ther. 2007;29(10):2246-55.
Orzeck, E. A., Shi, N., & Blumentals, W. A. (2007). Oseltamivir and the risk of influenza-related complications and hospitalizations in patients with diabetes. Clinical Therapeutics, 29(10), 2246-55.
Orzeck EA, Shi N, Blumentals WA. Oseltamivir and the Risk of Influenza-related Complications and Hospitalizations in Patients With Diabetes. Clin Ther. 2007;29(10):2246-55. PubMed PMID: 18042482.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oseltamivir and the risk of influenza-related complications and hospitalizations in patients with diabetes. AU - Orzeck,Eric A, AU - Shi,Nianwen, AU - Blumentals,William A, PY - 2007/08/16/accepted PY - 2007/11/29/pubmed PY - 2008/2/2/medline PY - 2007/11/29/entrez SP - 2246 EP - 55 JF - Clinical therapeutics JO - Clin Ther VL - 29 IS - 10 N2 - OBJECTIVE: This subgroup analysis of a retrospective cohort study examined, from a managed care perspective, the risk of influenza-related complications and hospitalizations in patients with diabetes who were prescribed oseltamivir for the treatment of influenza and those who were not prescribed antiviral treatment. METHODS: Health insurance claims data from the Thomson Healthcare MarketScan Research Database for 6 influenza seasons (October 1-March 31) between 2000 and 2006 were used to identify patients aged >/=18 years with influenza and diabetes. Patients who received a prescription for oseltamivir within 1 day of a diagnosis of influenza were compared with those who received no antiviral treatment. Outcomes included the frequency of pneumonia, respiratory diagnoses, and otitis media and its complications, and rates of hospitalization within 14 days of the diagnosis of influenza. Cox proportional hazards regression was used to determine the relative risk (RR) of influenza-related complications and hospitalizations. RESULTS: A total of 9090 patients with diabetes and a diagnosis of influenza were identified who met all study criteria. Of these, 2919 (32%) received a prescription for oseltamivir and 6171 (68%) received no antiviral treatment. Patients receiving oseltamivir had a significant 17% reduction in the risk of respiratory illnesses (RR = 0.83; 95% CI, 0.73-0.93) and a 30% reduction in the risk of hospitalization for any reason (RR = 0.70; 95% CI, 0.52-0.94). There were no significant differences between the oseltamivir and control groups in terms of the risks for pneumonia (RR = 0.87; 95% CI, 0.64-1.18), otitis media and its complications (RR = 0.96; 95% CI, 0.48-1.91), or hospitalization for pneumonia (RR = 0.81; 95% CI, 0.41-1.58). CONCLUSION: In this retrospective study, the risk of influenza-associated respiratory illnesses and the number of hospitalizations for any reason were reduced in patients with diabetes who were prescribed oseltamivir compared with an unmatched group that was not prescribed antiviral therapy. SN - 0149-2918 UR - https://www.unboundmedicine.com/medline/citation/18042482/Oseltamivir_and_the_risk_of_influenza_related_complications_and_hospitalizations_in_patients_with_diabetes_ DB - PRIME DP - Unbound Medicine ER -