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Lack of association of alcohol and tobacco with HPV16-associated head and neck cancer.
J Natl Cancer Inst. 2007 Dec 05; 99(23):1801-10.JNCI

Abstract

BACKGROUND

Human papillomavirus type 16 (HPV16) seropositivity and alcohol and tobacco use have been associated with risk of head and neck squamous cell carcinoma (HNSCC). However, it is less clear whether HPV16 influences HNSCC risk associated with alcohol and tobacco use.

METHODS

Incident cases of HNSCC diagnosed between December 1999 and December 2003 were identified from nine medical facilities in Greater Boston, MA. Control subjects were frequency matched to case subjects on age, sex, and town of residence. A total of 485 case subjects and 549 control subjects reported information on lifetime smoking and alcohol consumption and provided sera, which was used to determine presence of HPV16 antibodies. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of HNSCC risk by alcohol consumption (drinks per week: < 3, 3 to < 8, 8 to < 25, > or = 25) and smoking (pack-years: none, > 0 to < 20, 20 to < 45, > or = 45), adjusting for age, sex, race, education, and HPV16 serology. Polytomous logistic regression was used to estimate odds ratios and 95% confidence intervals for the association of HPV16 serology, alcohol consumption, and tobacco use in site-specific analyses. All statistical tests were two-sided.

RESULTS

The strongest risk factors by tumor site were smoking for laryngeal cancer, alcohol for cancer of the oral cavity, and HPV16 for pharyngeal cancer. For pharyngeal cancer, risk increased with increasing alcohol consumption (OR(> or = 25 versus < 3 drinks per week) = 5.1, 95% CI = 2.4 to 11.0) and smoking (OR(> or = 45 pack-years versus never smoker) = 6.9, 95% CI = 3.1 to 15.1) among HPV16-seronegative subjects but not among HPV16-seropositive subjects (P(interaction, HPV16 serology and alcohol) = .002; P(interaction, HPV16 serology and smoking) = .007). Among light drinkers or never smokers, HPV16 seropositivity was associated with a 30-fold increased risk of pharyngeal cancer.

CONCLUSIONS

Alcohol or tobacco use does not further increase risk of HPV16-associated pharyngeal cancer. HNSCC risk associated with smoking, alcohol, and HPV16 differs by tumor site.

Authors+Show Affiliations

Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18042931

Citation

Applebaum, Katie M., et al. "Lack of Association of Alcohol and Tobacco With HPV16-associated Head and Neck Cancer." Journal of the National Cancer Institute, vol. 99, no. 23, 2007, pp. 1801-10.
Applebaum KM, Furniss CS, Zeka A, et al. Lack of association of alcohol and tobacco with HPV16-associated head and neck cancer. J Natl Cancer Inst. 2007;99(23):1801-10.
Applebaum, K. M., Furniss, C. S., Zeka, A., Posner, M. R., Smith, J. F., Bryan, J., Eisen, E. A., Peters, E. S., McClean, M. D., & Kelsey, K. T. (2007). Lack of association of alcohol and tobacco with HPV16-associated head and neck cancer. Journal of the National Cancer Institute, 99(23), 1801-10.
Applebaum KM, et al. Lack of Association of Alcohol and Tobacco With HPV16-associated Head and Neck Cancer. J Natl Cancer Inst. 2007 Dec 5;99(23):1801-10. PubMed PMID: 18042931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of association of alcohol and tobacco with HPV16-associated head and neck cancer. AU - Applebaum,Katie M, AU - Furniss,C Sloane, AU - Zeka,Ariana, AU - Posner,Marshall R, AU - Smith,Judith F, AU - Bryan,Janine, AU - Eisen,Ellen A, AU - Peters,Edward S, AU - McClean,Michael D, AU - Kelsey,Karl T, Y1 - 2007/11/27/ PY - 2007/11/29/pubmed PY - 2007/12/14/medline PY - 2007/11/29/entrez SP - 1801 EP - 10 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 99 IS - 23 N2 - BACKGROUND: Human papillomavirus type 16 (HPV16) seropositivity and alcohol and tobacco use have been associated with risk of head and neck squamous cell carcinoma (HNSCC). However, it is less clear whether HPV16 influences HNSCC risk associated with alcohol and tobacco use. METHODS: Incident cases of HNSCC diagnosed between December 1999 and December 2003 were identified from nine medical facilities in Greater Boston, MA. Control subjects were frequency matched to case subjects on age, sex, and town of residence. A total of 485 case subjects and 549 control subjects reported information on lifetime smoking and alcohol consumption and provided sera, which was used to determine presence of HPV16 antibodies. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of HNSCC risk by alcohol consumption (drinks per week: < 3, 3 to < 8, 8 to < 25, > or = 25) and smoking (pack-years: none, > 0 to < 20, 20 to < 45, > or = 45), adjusting for age, sex, race, education, and HPV16 serology. Polytomous logistic regression was used to estimate odds ratios and 95% confidence intervals for the association of HPV16 serology, alcohol consumption, and tobacco use in site-specific analyses. All statistical tests were two-sided. RESULTS: The strongest risk factors by tumor site were smoking for laryngeal cancer, alcohol for cancer of the oral cavity, and HPV16 for pharyngeal cancer. For pharyngeal cancer, risk increased with increasing alcohol consumption (OR(> or = 25 versus < 3 drinks per week) = 5.1, 95% CI = 2.4 to 11.0) and smoking (OR(> or = 45 pack-years versus never smoker) = 6.9, 95% CI = 3.1 to 15.1) among HPV16-seronegative subjects but not among HPV16-seropositive subjects (P(interaction, HPV16 serology and alcohol) = .002; P(interaction, HPV16 serology and smoking) = .007). Among light drinkers or never smokers, HPV16 seropositivity was associated with a 30-fold increased risk of pharyngeal cancer. CONCLUSIONS: Alcohol or tobacco use does not further increase risk of HPV16-associated pharyngeal cancer. HNSCC risk associated with smoking, alcohol, and HPV16 differs by tumor site. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/18042931/Lack_of_association_of_alcohol_and_tobacco_with_HPV16_associated_head_and_neck_cancer_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djm233 DB - PRIME DP - Unbound Medicine ER -