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Mediterranean diet and essential tremor. A case-control study.
Neuroepidemiology 2007; 29(3-4):170-7N

Abstract

BACKGROUND

Higher adherence to the Mediterranean diet (MeDi) has been related to lower Alzheimer's disease risk. Some dietary factors have been studied in patients with essential tremor (ET), but the MeDi's effect has not been investigated.

METHODS

Adherence to the MeDi was calculated from a food frequency questionnaire administered in a case-control study of environmental epidemiology of ET in the New York Tri-State area. Logistic regression models were used to examine whether adherence to the MeDi predicted ET (vs. control) outcome. The models adjusted for age, gender, ethnicity, education, caloric intake, body mass index, smoking, ethanol consumption, coffee intake and blood harmane concentrations.

RESULTS

148 ET cases adhered less to MeDi (0-9 scale with higher scores indicating higher adherence) than 250 controls (mean 4.3 +/- 1.7 vs. 4.7 +/- 1.7; p = 0.03). Higher adherence to MeDi was associated with lower odds for ET [0.78 (0.61-0.99); p = 0.042]. As compared to subjects at the lowest MeDi adherence tertile, those at the middle tertile had lower ET odds [0.41 (0.16-1.05)], while subjects at the highest tertile had an even lower ET odds [0.29 (0.10-0.82); p for trend 0.021].

CONCLUSIONS

Compared to controls, ET cases adhered less to MeDi. The gradual reduction in ET odds with higher MeDi adherence tertiles suggests a possible dose-response effect. The mechanisms that underlie this association merit further study.

Authors+Show Affiliations

Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18043001

Citation

Scarmeas, Nikolaos, and Elan D. Louis. "Mediterranean Diet and Essential Tremor. a Case-control Study." Neuroepidemiology, vol. 29, no. 3-4, 2007, pp. 170-7.
Scarmeas N, Louis ED. Mediterranean diet and essential tremor. A case-control study. Neuroepidemiology. 2007;29(3-4):170-7.
Scarmeas, N., & Louis, E. D. (2007). Mediterranean diet and essential tremor. A case-control study. Neuroepidemiology, 29(3-4), pp. 170-7.
Scarmeas N, Louis ED. Mediterranean Diet and Essential Tremor. a Case-control Study. Neuroepidemiology. 2007;29(3-4):170-7. PubMed PMID: 18043001.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mediterranean diet and essential tremor. A case-control study. AU - Scarmeas,Nikolaos, AU - Louis,Elan D, Y1 - 2007/11/27/ PY - 2007/11/29/pubmed PY - 2008/4/9/medline PY - 2007/11/29/entrez SP - 170 EP - 7 JF - Neuroepidemiology JO - Neuroepidemiology VL - 29 IS - 3-4 N2 - BACKGROUND: Higher adherence to the Mediterranean diet (MeDi) has been related to lower Alzheimer's disease risk. Some dietary factors have been studied in patients with essential tremor (ET), but the MeDi's effect has not been investigated. METHODS: Adherence to the MeDi was calculated from a food frequency questionnaire administered in a case-control study of environmental epidemiology of ET in the New York Tri-State area. Logistic regression models were used to examine whether adherence to the MeDi predicted ET (vs. control) outcome. The models adjusted for age, gender, ethnicity, education, caloric intake, body mass index, smoking, ethanol consumption, coffee intake and blood harmane concentrations. RESULTS: 148 ET cases adhered less to MeDi (0-9 scale with higher scores indicating higher adherence) than 250 controls (mean 4.3 +/- 1.7 vs. 4.7 +/- 1.7; p = 0.03). Higher adherence to MeDi was associated with lower odds for ET [0.78 (0.61-0.99); p = 0.042]. As compared to subjects at the lowest MeDi adherence tertile, those at the middle tertile had lower ET odds [0.41 (0.16-1.05)], while subjects at the highest tertile had an even lower ET odds [0.29 (0.10-0.82); p for trend 0.021]. CONCLUSIONS: Compared to controls, ET cases adhered less to MeDi. The gradual reduction in ET odds with higher MeDi adherence tertiles suggests a possible dose-response effect. The mechanisms that underlie this association merit further study. SN - 1423-0208 UR - https://www.unboundmedicine.com/medline/citation/18043001/Mediterranean_diet_and_essential_tremor__A_case_control_study_ L2 - https://www.karger.com?DOI=10.1159/000111579 DB - PRIME DP - Unbound Medicine ER -