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Porokeratoma.
Am J Surg Pathol. 2007 Dec; 31(12):1897-901.AJ

Abstract

Cornoid lamellation is a specific disorder of epidermal maturation manifested by a vertical "column" of parakeratosis and is the hallmark of porokeratosis. The cornoid lamella is characterized by a ridgelike parakeratosis. We present 11 patients with solitary lesions of a distinct pattern of cornoid lamellation. The mean age at presentation clinically was 57 years; there were 9 men and 2 women. The duration of the lesions ranged from 3 months to 5 years (mean of 23 mo). All lesions were solitary, distributed mainly on the distal upper and lower limbs, and were clinically described as hyperkeratotic plaques or nodules; some were verrucous. Histologic examination showed a well-defined lesion characterized by acanthosis and verrucous hyperplasia with prominent multiple and confluent cornoid lamellae. No additional lesions were identified in any patient, with a mean follow-up duration of 34 months. No personal or family history of porokeratosis was elicited and no immunosuppressive conditions were noted. These lesions with multiple and confluent cornoid lamellae represent benign acanthomas with features of porokeratosis. As a solitary tumorlike lesion, it is akin to warty dyskeratoma and epidermolytic acanthoma, thus we have coined the term porokeratoma.

Authors+Show Affiliations

Department of Pathology and Immunology, Barnes-Jewish Hospital/Washington University School of Medicine, St Louis, MO, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18043046

Citation

Walsh, Sarah N., et al. "Porokeratoma." The American Journal of Surgical Pathology, vol. 31, no. 12, 2007, pp. 1897-901.
Walsh SN, Hurt MA, Santa Cruz DJ. Porokeratoma. Am J Surg Pathol. 2007;31(12):1897-901.
Walsh, S. N., Hurt, M. A., & Santa Cruz, D. J. (2007). Porokeratoma. The American Journal of Surgical Pathology, 31(12), 1897-901.
Walsh SN, Hurt MA, Santa Cruz DJ. Porokeratoma. Am J Surg Pathol. 2007;31(12):1897-901. PubMed PMID: 18043046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Porokeratoma. AU - Walsh,Sarah N, AU - Hurt,Mark A, AU - Santa Cruz,Daniel J, PY - 2007/11/29/pubmed PY - 2008/2/2/medline PY - 2007/11/29/entrez SP - 1897 EP - 901 JF - The American journal of surgical pathology JO - Am. J. Surg. Pathol. VL - 31 IS - 12 N2 - Cornoid lamellation is a specific disorder of epidermal maturation manifested by a vertical "column" of parakeratosis and is the hallmark of porokeratosis. The cornoid lamella is characterized by a ridgelike parakeratosis. We present 11 patients with solitary lesions of a distinct pattern of cornoid lamellation. The mean age at presentation clinically was 57 years; there were 9 men and 2 women. The duration of the lesions ranged from 3 months to 5 years (mean of 23 mo). All lesions were solitary, distributed mainly on the distal upper and lower limbs, and were clinically described as hyperkeratotic plaques or nodules; some were verrucous. Histologic examination showed a well-defined lesion characterized by acanthosis and verrucous hyperplasia with prominent multiple and confluent cornoid lamellae. No additional lesions were identified in any patient, with a mean follow-up duration of 34 months. No personal or family history of porokeratosis was elicited and no immunosuppressive conditions were noted. These lesions with multiple and confluent cornoid lamellae represent benign acanthomas with features of porokeratosis. As a solitary tumorlike lesion, it is akin to warty dyskeratoma and epidermolytic acanthoma, thus we have coined the term porokeratoma. SN - 0147-5185 UR - https://www.unboundmedicine.com/medline/citation/18043046/Porokeratoma_ L2 - http://dx.doi.org/10.1097/PAS.0b013e31806910c7 DB - PRIME DP - Unbound Medicine ER -