Porokeratoma.Am J Surg Pathol. 2007 Dec; 31(12):1897-901.AJ
Cornoid lamellation is a specific disorder of epidermal maturation manifested by a vertical "column" of parakeratosis and is the hallmark of porokeratosis. The cornoid lamella is characterized by a ridgelike parakeratosis. We present 11 patients with solitary lesions of a distinct pattern of cornoid lamellation. The mean age at presentation clinically was 57 years; there were 9 men and 2 women. The duration of the lesions ranged from 3 months to 5 years (mean of 23 mo). All lesions were solitary, distributed mainly on the distal upper and lower limbs, and were clinically described as hyperkeratotic plaques or nodules; some were verrucous. Histologic examination showed a well-defined lesion characterized by acanthosis and verrucous hyperplasia with prominent multiple and confluent cornoid lamellae. No additional lesions were identified in any patient, with a mean follow-up duration of 34 months. No personal or family history of porokeratosis was elicited and no immunosuppressive conditions were noted. These lesions with multiple and confluent cornoid lamellae represent benign acanthomas with features of porokeratosis. As a solitary tumorlike lesion, it is akin to warty dyskeratoma and epidermolytic acanthoma, thus we have coined the term porokeratoma.