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The Cleveland Clinic PediPump: anatomic modeling and virtual fitting studies in a lamb model.
ASAIO J. 2007 Nov-Dec; 53(6):716-9.AJ

Abstract

Implantation of ventricular assist devices (VADs) is challenging in small patients with limited space in the chest. We created three-dimensional models of lambs to facilitate fitting of the PediPump, a pediatric VAD currently under development. Serial computed tomography (CT) scans were acquired at multiple time points (n = 8) for three lambs. Digital models were created using these CT datasets and three-dimensional image processing software (Mimics, Materialise). Pixels representing the heart and chest wall were rendered as three-dimensional models. Using three-dimensional model manipulation software (Magics RP, Materialise), on-screen models of extravascular and intravascular VADs were placed in right, left and biventricular support configurations to determine optimal placement. A cannulation strategy was established and in some cases three-dimensional models of the inflow and outflow grafts were created. After the final CT study, an open-chest fitting study was performed using rapid prototype models of the pediatric VAD and cannulas. The pump location and orientation predictions from the virtual fitting studies matched those determined at the time of the open-chest fitting studies. Using three-dimensional modeling, we have established a fitting protocol that facilitates animal implantations; the same modeling techniques may be useful for device fitting in humans.

Authors+Show Affiliations

Noecker AM
Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Cingoz F
No affiliation info available
Ootaki Y
No affiliation info available
Liu J
No affiliation info available
Kuzmiak S
No affiliation info available
Kopcak MW
No affiliation info available
Fukamachi K
No affiliation info available
Duncan BW
No affiliation info available

MeSH

AnimalsBiomedical EngineeringBody WeightHeart-Assist DevicesImage Processing, Computer-AssistedImaging, Three-DimensionalModels, CardiovascularProsthesis DesignProsthesis FittingSheepSoftwareTomography, X-Ray Computed

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18043154

Citation

Noecker, Angela M., et al. "The Cleveland Clinic PediPump: Anatomic Modeling and Virtual Fitting Studies in a Lamb Model." ASAIO Journal (American Society for Artificial Internal Organs : 1992), vol. 53, no. 6, 2007, pp. 716-9.
Noecker AM, Cingoz F, Ootaki Y, et al. The Cleveland Clinic PediPump: anatomic modeling and virtual fitting studies in a lamb model. ASAIO J. 2007;53(6):716-9.
Noecker, A. M., Cingoz, F., Ootaki, Y., Liu, J., Kuzmiak, S., Kopcak, M. W., Fukamachi, K., & Duncan, B. W. (2007). The Cleveland Clinic PediPump: anatomic modeling and virtual fitting studies in a lamb model. ASAIO Journal (American Society for Artificial Internal Organs : 1992), 53(6), 716-9.
Noecker AM, et al. The Cleveland Clinic PediPump: Anatomic Modeling and Virtual Fitting Studies in a Lamb Model. ASAIO J. 2007 Nov-Dec;53(6):716-9. PubMed PMID: 18043154.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Cleveland Clinic PediPump: anatomic modeling and virtual fitting studies in a lamb model. AU - Noecker,Angela M, AU - Cingoz,Faruk, AU - Ootaki,Yoshio, AU - Liu,Jenny, AU - Kuzmiak,Stacie, AU - Kopcak,Mike W, AU - Fukamachi,Kiyotaka, AU - Duncan,Brian W, PY - 2007/11/29/pubmed PY - 2008/1/8/medline PY - 2007/11/29/entrez SP - 716 EP - 9 JF - ASAIO journal (American Society for Artificial Internal Organs : 1992) JO - ASAIO J VL - 53 IS - 6 N2 - Implantation of ventricular assist devices (VADs) is challenging in small patients with limited space in the chest. We created three-dimensional models of lambs to facilitate fitting of the PediPump, a pediatric VAD currently under development. Serial computed tomography (CT) scans were acquired at multiple time points (n = 8) for three lambs. Digital models were created using these CT datasets and three-dimensional image processing software (Mimics, Materialise). Pixels representing the heart and chest wall were rendered as three-dimensional models. Using three-dimensional model manipulation software (Magics RP, Materialise), on-screen models of extravascular and intravascular VADs were placed in right, left and biventricular support configurations to determine optimal placement. A cannulation strategy was established and in some cases three-dimensional models of the inflow and outflow grafts were created. After the final CT study, an open-chest fitting study was performed using rapid prototype models of the pediatric VAD and cannulas. The pump location and orientation predictions from the virtual fitting studies matched those determined at the time of the open-chest fitting studies. Using three-dimensional modeling, we have established a fitting protocol that facilitates animal implantations; the same modeling techniques may be useful for device fitting in humans. SN - 1538-943X UR - https://www.unboundmedicine.com/medline/citation/18043154/The_Cleveland_Clinic_PediPump:_anatomic_modeling_and_virtual_fitting_studies_in_a_lamb_model_ DB - PRIME DP - Unbound Medicine ER -