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The PediPump: a versatile, implantable pediatric ventricular assist device-update III.
ASAIO J. 2007 Nov-Dec; 53(6):730-3.AJ

Abstract

The PediPump is a passive magnetic bearing, mixed flow, rotary ventricular assist device designed to provide support for the entire range of patient sizes encountered in pediatrics. Blood enters axially at the inlet and is accelerated and turned in the impeller to exit the pump at an intermediate angle. The size of the PediPump facilitates standard cannulation strategies with substantially downsized components. The program pursues three specific objectives: 1) System engineering: Progress within the last year has focused on the assembly and testing of PediPump prototypes. Initial in vitro hydraulic performance and hemolysis testing were judged satisfactory. 2) Anatomic fitting studies: As part of the PediPump program, three-dimensional modeling techniques based on routine, clinically obtained computerized tomography (CT) scans have been developed. During 2006, the same techniques developed for clinical scans were applied to CT scans obtained from sheep to guide the presurgical planning. 3) Animal studies: Animal implantation of PediPump prototypes commenced in July 2006. A total of four 6 hour acute studies were performed throughout the remainder of the year. In vivo performance was satisfactory and compared well with the in vitro results. Hemolysis levels were low.

Authors+Show Affiliations

Weber S
Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Ohio 44195, USA.
Dudzinski DT
No affiliation info available
Gu L
No affiliation info available
Mielke N
No affiliation info available
Casas F
No affiliation info available
Noecker AM
No affiliation info available
Saeed D
No affiliation info available
Ootaki Y
No affiliation info available
Fukamachi K
No affiliation info available
Smith WA
No affiliation info available
Duncan BW
No affiliation info available

MeSH

AnimalsAnimals, NewbornBiomedical EngineeringBlood Physiological PhenomenaCadaverCattleChildChild, PreschoolHeart-Assist DevicesHemodynamicsHemolysisHumansImaging, Three-DimensionalMagnetic Resonance ImagingProsthesis DesignProsthesis FittingProsthesis ImplantationSheepTomography, X-Ray Computed

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18043157

Citation

Weber, Stephan, et al. "The PediPump: a Versatile, Implantable Pediatric Ventricular Assist Device-update III." ASAIO Journal (American Society for Artificial Internal Organs : 1992), vol. 53, no. 6, 2007, pp. 730-3.
Weber S, Dudzinski DT, Gu L, et al. The PediPump: a versatile, implantable pediatric ventricular assist device-update III. ASAIO J. 2007;53(6):730-3.
Weber, S., Dudzinski, D. T., Gu, L., Mielke, N., Casas, F., Noecker, A. M., Saeed, D., Ootaki, Y., Fukamachi, K., Smith, W. A., & Duncan, B. W. (2007). The PediPump: a versatile, implantable pediatric ventricular assist device-update III. ASAIO Journal (American Society for Artificial Internal Organs : 1992), 53(6), 730-3.
Weber S, et al. The PediPump: a Versatile, Implantable Pediatric Ventricular Assist Device-update III. ASAIO J. 2007 Nov-Dec;53(6):730-3. PubMed PMID: 18043157.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The PediPump: a versatile, implantable pediatric ventricular assist device-update III. AU - Weber,Stephan, AU - Dudzinski,David T, AU - Gu,Lei, AU - Mielke,Nicole, AU - Casas,Fernando, AU - Noecker,Angela M, AU - Saeed,Diyar, AU - Ootaki,Yoshio, AU - Fukamachi,Kiyotaka, AU - Smith,William A, AU - Duncan,Brian W, PY - 2007/11/29/pubmed PY - 2008/1/8/medline PY - 2007/11/29/entrez SP - 730 EP - 3 JF - ASAIO journal (American Society for Artificial Internal Organs : 1992) JO - ASAIO J VL - 53 IS - 6 N2 - The PediPump is a passive magnetic bearing, mixed flow, rotary ventricular assist device designed to provide support for the entire range of patient sizes encountered in pediatrics. Blood enters axially at the inlet and is accelerated and turned in the impeller to exit the pump at an intermediate angle. The size of the PediPump facilitates standard cannulation strategies with substantially downsized components. The program pursues three specific objectives: 1) System engineering: Progress within the last year has focused on the assembly and testing of PediPump prototypes. Initial in vitro hydraulic performance and hemolysis testing were judged satisfactory. 2) Anatomic fitting studies: As part of the PediPump program, three-dimensional modeling techniques based on routine, clinically obtained computerized tomography (CT) scans have been developed. During 2006, the same techniques developed for clinical scans were applied to CT scans obtained from sheep to guide the presurgical planning. 3) Animal studies: Animal implantation of PediPump prototypes commenced in July 2006. A total of four 6 hour acute studies were performed throughout the remainder of the year. In vivo performance was satisfactory and compared well with the in vitro results. Hemolysis levels were low. SN - 1538-943X UR - https://www.unboundmedicine.com/medline/citation/18043157/The_PediPump:_a_versatile_implantable_pediatric_ventricular_assist_device_update_III_ DB - PRIME DP - Unbound Medicine ER -